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Hauptvortrag - Ulrike Lüken
Donnerstag, 03.06.2021:
13:15 - 14:15

Chair der Sitzung: Birgit Derntl, Universität Tübingen
Ort: Plenum

Optimizing psychological treatments: from mechanisms to predictions to clinical utility

Zusammenfassung der Sitzung

Although psychological treatments including cognitive-behavioral therapy (CBT) work in principle to improve mental health, it appears not to work equally well for everyone: recent evidence shows that nearly every second patient suffering from an anxiety disorder fails to benefit in a clinically meaningful way - with severe consequences for patients and increasing costs for societies. Precision mental health aims to identify patients at risk for non-response already prior to treatment initialization and to improve treatments based on an in-depth mechanistic understanding. During the first part of this lecture, I will give insights into putative mechanisms that may predispose patients not to benefit from CBT, focusing on emotion regulation and its neurobiological underpinnings. In the second part, we will shift to the field of predictive analytics and its application to the prediction of treatment outcome (theranostics). Third, initial evidence and first ideas (including ethical considerations) how to implement such a theranostic pipeline into clinical utility will be discussed.

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