10:00am - 10:30am
Invited Talk: Selective laser sintering 3D printing of bespoke medications
University College London, United Kingdom
3D printing is a rapid manufacturing technology that has found promising applications in many fields, including pharmacy. In particular, laser-based technologies enable the creation of precise and intricate structures, potentially causing a paradigm shift in medicine design, manufacture and use. As an example, early-phase drug development (such as preclinical studies and first-in-human trials) could be expedited by using these technologies to rapidly produce formulations with excellent dose flexibility at low cost, on demand. Similarly, they could support formulation development because they have the capability to produce rapid product iterations for testing, such as excipient compatibility and drug release. Within hospitals and pharmacies, such technologies could accelerate the field of personalised medicine by moving treatment away from a ‘one size fits all approach’ towards personalisation. This presentation will give an overview on the use of a laser-based 3D printing technology and its promising applications, highlighting its potential in personalising medications.
10:30am - 10:45am
Laser directed energy deposition produces improved cp Ti for dental prosthetic applications
1CINTECX, University of Vigo, LaserON Research Group, Vigo, SPAIN; 2Corus-Fegoba, A Coruña, SPAIN; 3School of Dentistry, Universitat Internacional de Catalunya, Barcelona, SPAIN; 4Materials Engineering, Applied Mechanics and Construction Department, University of Vigo, Vigo, SPAIN; 5Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, SPAINin
Titanium and titanium alloys are widely employed in biomedical applications by virtue of their remarkable corrosion resistance, biocompatibility, exceptional specific strength and relatively low elastic modulus. Commercially pure titanium (cp-Ti) is a designation for titanium with reduced content of alloying elements, having a great resistance to corrosion and reduced cytotoxicity.
Laser directed energy deposition (LDED) is an additive manufacturing method able to produce metallic materials of great quality. By controlling the cooling rates, the material microstructure can be tuned in order to improve its mechanical/chemical properties. In the present work, LDED using a high power diode laser as energy source, was used to produce cp-Ti parts of grade 4. The cp-Ti obtained by LDED showed a higher mechanical performance than the commercial counterpart: 7% increment of ultimate tensile strength and 30% increment of toughness. These results can be attributed to a specific microstructure modification inherent to the LDED process.
10:45am - 11:00am
Additive manufacturing for minimally invasive endomicroscopy
TU Dresden, Germany
Miniaturized flexible endoscopes employ coherent fiber bundles (CFB) to transfer intensity information by using lenses. This increases the footprint of the endoscope to several millimeters. Furthermore, the phase information of the light is distorted during transfer due to manufacturing errors of the CFB, which limits the endoscope to 2D imaging. Calibrating and compensating the phase distortion allows for lens less imaging. We present, the use of additive manufacturing to apply diffractive optical elements (DOE) onto the fiber facet for phase compensation. Using 2P-polymerization axial resolutions better than 20 nm can be achieved. This enables robust and cost efficient, endoscopes for 3D imaging. The influence of the DOE quality especially the axial resolution towards the image quality is discussed. With a total diameter below 400 µm, novel applications for instance for in-vivo cancer diagnostics in the brain can be envisioned.