Conference Agenda

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

 
Only Sessions at Location/Venue 
 
 
Session Overview
Location: Poster Location
Date: Monday, 25/Aug/2025
10:45am
-
11:30am
Poster Exhibition: M / Monday posters
Location: Poster Location
 

Longitudinal Psychological Status and Risk of Major Cardiovascular Events (MCE) in Individuals with Pre-Existing Myocardial Infarction: A Joint Modeling Approach

Nasrin Salimian, Marjan Mansourian, Masoumeh Sadeghi, Hamidreza Roohafza, Hamid Reza Marateb



Cardio-metabolic traits and its socioeconomic differentials among school children including MONW phenotypes in India: A baseline characteristics of LEAP-C cohort

Kalaivani Mani, Chitralok Hemraj, Varhlunchhungi Varhlunchhungi, Lakshmy Ramakrishnan, Sumit Malhotra, Sanjeev Kumar Gupta, Raman Kumar Marwaha, Ransi Ann Abraham, Monika Arora, Tina Rawal, Maroof Ahmad Khan, Aditi Sinha, Nikhil Tandon



External validation of SMART2 model for recurrent cardiovascular risk

Jasper Wilhelmus Adrianus van Egeraat, Nan van Geloven, Hendrikus van Os



Multi-disease risk models to target concomitant diseases and their interactions: Insights on cardio-renal-metabolic syndrome in England

Stelios Boulitsakis Logothetis, Niels Peek, Angela Wood



Machine learning methods for analyzing longitudinal health data streams: A comparative study

Inês Sousa



Evaluating the fairness of a clinical prediction model for outcomes following psychological treatment in the UK’s National Health Service

Nour Kanso, Thalia C. Eley, Ewan Carr



Multiple Imputation vs. Machine Learning for Handling Missing Data in Prediction Modelling: Which Best Balances Stability, Performance, and Computational Efficiency?

Pakpoom Wongyikul, Phichayut Phinyo, Noraworn jirattikanwong, Natthanaphop Isaradech, Wachiranun Sirikul, Arintaya Phrommintikul



Estimating rates of dental treatment and unmet dental need in a spatially explicit model in children in England, 2016-2018

Beatrice Catherine Downing



Statistical Approach to Assess the Impact of Hospital Settings on Optimal Staffing Levels

Diana Trutschel, Maryam Ahmadi Shad, Michael Ketzer, Jack Kuipers, Giusi Moffa, Michael Simon



Real-time predictions of bed occupancy in hospitals.

Ensor Rafael Palacios, Theresa Smith



Positive and negative predictive values of diagnostic tests using area under the curve

Kanae Takahashi, Kouji Yamamoto



Freely accessible software for recruitment prediction and recruitment monitoring: Is it necessary?

Philip Heesen, Manuela Ott, Katarina Zatkova, Malgorzata Roos



On moderation in a Bayesian log-contrast compositional model with a total. Interaction between extreme temperatures and pollutants on mortality

Germá Coenders, Javier Palarea-Albadalejo, Marc Saez, Maria A. Barceló



Graphical inference in nonparametric hypothesis testing: A two-dimensional grid framework for analysis and visualization

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



On regression analysis of interval-valued data based on order statistics

Ryo Mizushima, Asanao Shimokawa



Two-sided Beyesian simultaneous credible bands in linear regression model

Fei Yang



Cell composition analysis with unmeasured confounding

Amber Huybrechts, Koen Van den Berge, Sanne Roels, Oliver Dukes



Temporal transcriptomic analysis of microexon alternative splicing in mouse neurodevelopmental genes

Jimin Kim, Kwanghoon Cho, Jahyun Yun, Dayeon Kang



A Robust Method for Accurate Reconstruction of 3D Genome Conformation from Hi-C Data

Insu Jang, MInsu Park



Balancing Accuracy, Clinical Utility, and Explainability: A Machine Learning Approach to Prostate Cancer Prediction

Luis Mariano Esteban, Rocío Aznar, Angel Borque-Fernando, Alejandro Camón, Patricia Guerrero



Development of a thyroid cancer recurrence prediction calculator: A regression approach

Jiaxu Zeng



A comparison of methods for modelling multi-state cancer progression using screening data with censoring after intervention

Eddymurphy U. Akwiwu, Veerle M.H. Coupé, Johannes Berkhof, Thomas Klausch



ADHD and 10–Year Disease Progression from Initiating Pharmacotherapy for Hypertension to Death: A Multistate Modelling Analysis

Yiling Zhou, Douwe Postmus, Anne van Lammeren, Casper F.M. Franssen, Harold Snieder, Catharina A. Hartman



Understanding PSA Dynamics: Integrating Longitudinal Trajectories, Testing Patterns, and Disease Progression.

Birzhan Akynkozhayev, Benjamin Christoffersen, Mark Clements



Joint Modeling for Principal Stratification: Analyzing Stroke Events in CADASIL Patients Across NOTCH3 Variants

Léa Aguilhon, Sophie Tezenas du Montcel, Juliette Ortholand



Challenges in modelling neuropsychiatric symptoms in early Alzheimer's Disease

Rachid Abbas



Network models to decipher the Human exposome : application to food exposome patterns in the general population

Ima Bernada, Gregory Nuel, Cécilia Samieri



Study brain connectivity changes in Dementia with Lewy Bodies with Functional Conditional Gaussian Graphical Models

Alessia Mapelli, Laura Carini, Michela Carlotta Massi, Dario Arnaldi, Emanuele Di Angelantonio, Francesca Ieva, Sara Sommariva



LongiSurvSHAP: Explaining Survival Models with Longitudinal Features

Van Tuan NGUYEN, Lucas Ducrot, Agathe Guilloux



Prognostic Models for Recurrent Event Data

Victoria Watson, Laura Bonnett, Catrin Tudur-Smith



Unlocking diagnosis code for longitudinal modeling through representations from large language models

Fabian Kabus, Maren Hackenberg, Moritz Hess, Simon Ging, Maryam Farhadizadeh, Nadine Binder, Harald Binder



Machine Learning Perspectives in Survival Prediction Model Selection: Frequentist vs. Bayesian Approach

Emanuele Koumantakis, Valentina Bonuomo, Selene Grano, Fausto Castagnetti, Carlo Gambacorti-Passerini, Massimo Breccia, Maria Cristina Miggiano, Chiara Elena, Matteo Pacilli, Isabella Capodanno, Tamara Intermesoli, Monica Bocchia, Alessandra Iurlo, Fabio Ciceri, Fabrizio Pane, Federica Sorà, Barbara Scappini, Angelo Michele Carella, Elisabetta Abruzzese, Sara Galimberti, Sabrina Leonetti Crescenzi, Marco de Gobbi, Giuseppe Saglio, Daniela Cilloni, Carmen Fava, Paola Berchialla



Non-parametric methods for comparing survival functions with censored data: Exhaustive simulation of all possible beyond-observed censoring scenarios and computational analysis

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



Tree-based methods for length-biased survival data

Jinwoo Lee, Jiyu Sun, Donghwan Lee



Evaluating different pragmatic approaches for selecting the truncation time of the restricted mean survival time in randomized controlled trials

Léa Orsini, Andres Cardona, Emmanuel Lesaffre, David Dejardin, Gwénaël Le Teuff



Identifying risk factors for hospital readmission in home-based care: a study from a monographic paediatric cancer centre

Sara Perez-Jaume, Maria Antònia Colomar-Riutort, Anna Felip-Badia, Maria Fabregat, Laura Andrés-Zallo



A web-application for predicting Serious Adverse Event for guiding the enrollment procedure in Clinical Trials with Machine Learning Methods

Ajsi Kanapari, Corrado Lanera, Dario Gregori



Assessing the Overall Burden of Adverse Events in Clinical Trials: Approaches and Challenges

Seid Hamzic, Hans-Joachim Helms, Eva Rossman, Robert Walls



Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base

Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud



Information borrowing in phase II randomized dose-ranging clinical trials in oncology

Guillaume Mulier, Vincent Lévy, Lucie Biard



Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior

Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo



A Bayesian approach to decision making in early development clinical trials : An R solution.

Audrey Te-ying Yeo



Designing Clinical Trials in R with rpact and crmPack

Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke



Leveraging on historical controls in the design and analysis of phase II clinical trials

Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai



Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format

Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev



Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software

Yannick Vandendijck, Christina Fillmore, Lyn Taylor



Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation

Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao



Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes

Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel



CUtools: an R package for clinical utility analysis of predictive models

María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando



Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand

Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian



Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period

Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban



The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response

Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson



Topic modelling and time-series analysis to explore methodological trend evolution

Gabrielle Gauthier-Gagné, Tibor Schuster



Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments

Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell



Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial

Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare



Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand

Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John



Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data

Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri



An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics

Christos Christogiannis, Dimitris Mavridis



Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study

Corentin Choisy, Yseulys Dubuy, Véronique Sébille



Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example

Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales



Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study

Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen



Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS)

Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch



Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods

Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra



Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies

Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White



A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments

Kotaro Sasaki, Hisashi Noma



Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol

Nadia Dardenne, Anh Diep, Anne-Françoise Donneau



Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency

Mi Mi Ko



Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width

Paul Talsma, Francesco Innocenti



Sample size calculation methods for clinical trials using co-primary count endpoints

Takuma Ishihara, Kouji Yamamoto



Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials

Hao Jiang, Yonghong Gao



Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes

Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata



Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics

Lucie Fayette, Karl Brendel, France Mentré



Unbiased Estimation for Hierarchical Models in Clinical Trials

Raiann Joanna Hamshaw, Nanxuan Lin



Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma

Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann



Bayesian bivariate analysis of phase II basket trials enabling borrowing of information

Zhi Cao, Pavel Mozgunov, Haiyan Zheng



Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod

Yuki Fukuyama, Gosuke Homma, Masahiko Gosho



Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables

Vanessa Ihl, Ralf-Dieter Hilgers



Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach

Eisuke Hida, Satomi Okamura, Tomoharu Sato



Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study

Wenyue Li, Becky Turner, Duncan Gilbert, Ian White



Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials.

Teresa Engelbrecht, Alexandra Graf



A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions

Monika Jelizarow



Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials

Tomoharu Sato, Eisuke Hida



Dealing with missing values in adaptive N-of-1 trials

Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski



Adaptive clinical trial design with delayed treatment effects using elicited prior distributions

James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson

11:30am
-
1:00pm
Poster Exhibition: M / Monday posters
Location: Poster Location
 

Longitudinal Psychological Status and Risk of Major Cardiovascular Events (MCE) in Individuals with Pre-Existing Myocardial Infarction: A Joint Modeling Approach

Nasrin Salimian, Marjan Mansourian, Masoumeh Sadeghi, Hamidreza Roohafza, Hamid Reza Marateb



Cardio-metabolic traits and its socioeconomic differentials among school children including MONW phenotypes in India: A baseline characteristics of LEAP-C cohort

Kalaivani Mani, Chitralok Hemraj, Varhlunchhungi Varhlunchhungi, Lakshmy Ramakrishnan, Sumit Malhotra, Sanjeev Kumar Gupta, Raman Kumar Marwaha, Ransi Ann Abraham, Monika Arora, Tina Rawal, Maroof Ahmad Khan, Aditi Sinha, Nikhil Tandon



External validation of SMART2 model for recurrent cardiovascular risk

Jasper Wilhelmus Adrianus van Egeraat, Nan van Geloven, Hendrikus van Os



Multi-disease risk models to target concomitant diseases and their interactions: Insights on cardio-renal-metabolic syndrome in England

Stelios Boulitsakis Logothetis, Niels Peek, Angela Wood



Machine learning methods for analyzing longitudinal health data streams: A comparative study

Inês Sousa



Evaluating the fairness of a clinical prediction model for outcomes following psychological treatment in the UK’s National Health Service

Nour Kanso, Thalia C. Eley, Ewan Carr



Multiple Imputation vs. Machine Learning for Handling Missing Data in Prediction Modelling: Which Best Balances Stability, Performance, and Computational Efficiency?

Pakpoom Wongyikul, Phichayut Phinyo, Noraworn jirattikanwong, Natthanaphop Isaradech, Wachiranun Sirikul, Arintaya Phrommintikul



Estimating rates of dental treatment and unmet dental need in a spatially explicit model in children in England, 2016-2018

Beatrice Catherine Downing



Statistical Approach to Assess the Impact of Hospital Settings on Optimal Staffing Levels

Diana Trutschel, Maryam Ahmadi Shad, Michael Ketzer, Jack Kuipers, Giusi Moffa, Michael Simon



Real-time predictions of bed occupancy in hospitals.

Ensor Rafael Palacios, Theresa Smith



Positive and negative predictive values of diagnostic tests using area under the curve

Kanae Takahashi, Kouji Yamamoto



Freely accessible software for recruitment prediction and recruitment monitoring: Is it necessary?

Philip Heesen, Manuela Ott, Katarina Zatkova, Malgorzata Roos



On moderation in a Bayesian log-contrast compositional model with a total. Interaction between extreme temperatures and pollutants on mortality

Germá Coenders, Javier Palarea-Albadalejo, Marc Saez, Maria A. Barceló



Graphical inference in nonparametric hypothesis testing: A two-dimensional grid framework for analysis and visualization

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



On regression analysis of interval-valued data based on order statistics

Ryo Mizushima, Asanao Shimokawa



Two-sided Beyesian simultaneous credible bands in linear regression model

Fei Yang



Cell composition analysis with unmeasured confounding

Amber Huybrechts, Koen Van den Berge, Sanne Roels, Oliver Dukes



Temporal transcriptomic analysis of microexon alternative splicing in mouse neurodevelopmental genes

Jimin Kim, Kwanghoon Cho, Jahyun Yun, Dayeon Kang



A Robust Method for Accurate Reconstruction of 3D Genome Conformation from Hi-C Data

Insu Jang, MInsu Park



Balancing Accuracy, Clinical Utility, and Explainability: A Machine Learning Approach to Prostate Cancer Prediction

Luis Mariano Esteban, Rocío Aznar, Angel Borque-Fernando, Alejandro Camón, Patricia Guerrero



Development of a thyroid cancer recurrence prediction calculator: A regression approach

Jiaxu Zeng



A comparison of methods for modelling multi-state cancer progression using screening data with censoring after intervention

Eddymurphy U. Akwiwu, Veerle M.H. Coupé, Johannes Berkhof, Thomas Klausch



ADHD and 10–Year Disease Progression from Initiating Pharmacotherapy for Hypertension to Death: A Multistate Modelling Analysis

Yiling Zhou, Douwe Postmus, Anne van Lammeren, Casper F.M. Franssen, Harold Snieder, Catharina A. Hartman



Understanding PSA Dynamics: Integrating Longitudinal Trajectories, Testing Patterns, and Disease Progression.

Birzhan Akynkozhayev, Benjamin Christoffersen, Mark Clements



Joint Modeling for Principal Stratification: Analyzing Stroke Events in CADASIL Patients Across NOTCH3 Variants

Léa Aguilhon, Sophie Tezenas du Montcel, Juliette Ortholand



Challenges in modelling neuropsychiatric symptoms in early Alzheimer's Disease

Rachid Abbas



Network models to decipher the Human exposome : application to food exposome patterns in the general population

Ima Bernada, Gregory Nuel, Cécilia Samieri



Study brain connectivity changes in Dementia with Lewy Bodies with Functional Conditional Gaussian Graphical Models

Alessia Mapelli, Laura Carini, Michela Carlotta Massi, Dario Arnaldi, Emanuele Di Angelantonio, Francesca Ieva, Sara Sommariva



LongiSurvSHAP: Explaining Survival Models with Longitudinal Features

Van Tuan NGUYEN, Lucas Ducrot, Agathe Guilloux



Prognostic Models for Recurrent Event Data

Victoria Watson, Laura Bonnett, Catrin Tudur-Smith



Unlocking diagnosis code for longitudinal modeling through representations from large language models

Fabian Kabus, Maren Hackenberg, Moritz Hess, Simon Ging, Maryam Farhadizadeh, Nadine Binder, Harald Binder



Machine Learning Perspectives in Survival Prediction Model Selection: Frequentist vs. Bayesian Approach

Emanuele Koumantakis, Valentina Bonuomo, Selene Grano, Fausto Castagnetti, Carlo Gambacorti-Passerini, Massimo Breccia, Maria Cristina Miggiano, Chiara Elena, Matteo Pacilli, Isabella Capodanno, Tamara Intermesoli, Monica Bocchia, Alessandra Iurlo, Fabio Ciceri, Fabrizio Pane, Federica Sorà, Barbara Scappini, Angelo Michele Carella, Elisabetta Abruzzese, Sara Galimberti, Sabrina Leonetti Crescenzi, Marco de Gobbi, Giuseppe Saglio, Daniela Cilloni, Carmen Fava, Paola Berchialla



Non-parametric methods for comparing survival functions with censored data: Exhaustive simulation of all possible beyond-observed censoring scenarios and computational analysis

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



Tree-based methods for length-biased survival data

Jinwoo Lee, Jiyu Sun, Donghwan Lee



Evaluating different pragmatic approaches for selecting the truncation time of the restricted mean survival time in randomized controlled trials

Léa Orsini, Andres Cardona, Emmanuel Lesaffre, David Dejardin, Gwénaël Le Teuff



Identifying risk factors for hospital readmission in home-based care: a study from a monographic paediatric cancer centre

Sara Perez-Jaume, Maria Antònia Colomar-Riutort, Anna Felip-Badia, Maria Fabregat, Laura Andrés-Zallo



A web-application for predicting Serious Adverse Event for guiding the enrollment procedure in Clinical Trials with Machine Learning Methods

Ajsi Kanapari, Corrado Lanera, Dario Gregori



Assessing the Overall Burden of Adverse Events in Clinical Trials: Approaches and Challenges

Seid Hamzic, Hans-Joachim Helms, Eva Rossman, Robert Walls



Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base

Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud



Information borrowing in phase II randomized dose-ranging clinical trials in oncology

Guillaume Mulier, Vincent Lévy, Lucie Biard



Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior

Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo



A Bayesian approach to decision making in early development clinical trials : An R solution.

Audrey Te-ying Yeo



Designing Clinical Trials in R with rpact and crmPack

Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke



Leveraging on historical controls in the design and analysis of phase II clinical trials

Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai



Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format

Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev



Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software

Yannick Vandendijck, Christina Fillmore, Lyn Taylor



Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation

Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao



Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes

Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel



CUtools: an R package for clinical utility analysis of predictive models

María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando



Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand

Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian



Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period

Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban



The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response

Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson



Topic modelling and time-series analysis to explore methodological trend evolution

Gabrielle Gauthier-Gagné, Tibor Schuster



Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments

Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell



Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial

Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare



Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand

Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John



Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data

Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri



An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics

Christos Christogiannis, Dimitris Mavridis



Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study

Corentin Choisy, Yseulys Dubuy, Véronique Sébille



Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example

Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales



Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study

Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen



Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS)

Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch



Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods

Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra



Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies

Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White



A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments

Kotaro Sasaki, Hisashi Noma



Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol

Nadia Dardenne, Anh Diep, Anne-Françoise Donneau



Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency

Mi Mi Ko



Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width

Paul Talsma, Francesco Innocenti



Sample size calculation methods for clinical trials using co-primary count endpoints

Takuma Ishihara, Kouji Yamamoto



Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials

Hao Jiang, Yonghong Gao



Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes

Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata



Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics

Lucie Fayette, Karl Brendel, France Mentré



Unbiased Estimation for Hierarchical Models in Clinical Trials

Raiann Joanna Hamshaw, Nanxuan Lin



Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma

Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann



Bayesian bivariate analysis of phase II basket trials enabling borrowing of information

Zhi Cao, Pavel Mozgunov, Haiyan Zheng



Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod

Yuki Fukuyama, Gosuke Homma, Masahiko Gosho



Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables

Vanessa Ihl, Ralf-Dieter Hilgers



Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach

Eisuke Hida, Satomi Okamura, Tomoharu Sato



Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study

Wenyue Li, Becky Turner, Duncan Gilbert, Ian White



Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials.

Teresa Engelbrecht, Alexandra Graf



A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions

Monika Jelizarow



Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials

Tomoharu Sato, Eisuke Hida



Dealing with missing values in adaptive N-of-1 trials

Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski



Adaptive clinical trial design with delayed treatment effects using elicited prior distributions

James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson

1:00pm
-
2:00pm
Poster Exhibition: M / Monday posters
Location: Poster Location
 

Longitudinal Psychological Status and Risk of Major Cardiovascular Events (MCE) in Individuals with Pre-Existing Myocardial Infarction: A Joint Modeling Approach

Nasrin Salimian, Marjan Mansourian, Masoumeh Sadeghi, Hamidreza Roohafza, Hamid Reza Marateb



Cardio-metabolic traits and its socioeconomic differentials among school children including MONW phenotypes in India: A baseline characteristics of LEAP-C cohort

Kalaivani Mani, Chitralok Hemraj, Varhlunchhungi Varhlunchhungi, Lakshmy Ramakrishnan, Sumit Malhotra, Sanjeev Kumar Gupta, Raman Kumar Marwaha, Ransi Ann Abraham, Monika Arora, Tina Rawal, Maroof Ahmad Khan, Aditi Sinha, Nikhil Tandon



External validation of SMART2 model for recurrent cardiovascular risk

Jasper Wilhelmus Adrianus van Egeraat, Nan van Geloven, Hendrikus van Os



Multi-disease risk models to target concomitant diseases and their interactions: Insights on cardio-renal-metabolic syndrome in England

Stelios Boulitsakis Logothetis, Niels Peek, Angela Wood



Machine learning methods for analyzing longitudinal health data streams: A comparative study

Inês Sousa



Evaluating the fairness of a clinical prediction model for outcomes following psychological treatment in the UK’s National Health Service

Nour Kanso, Thalia C. Eley, Ewan Carr



Multiple Imputation vs. Machine Learning for Handling Missing Data in Prediction Modelling: Which Best Balances Stability, Performance, and Computational Efficiency?

Pakpoom Wongyikul, Phichayut Phinyo, Noraworn jirattikanwong, Natthanaphop Isaradech, Wachiranun Sirikul, Arintaya Phrommintikul



Estimating rates of dental treatment and unmet dental need in a spatially explicit model in children in England, 2016-2018

Beatrice Catherine Downing



Statistical Approach to Assess the Impact of Hospital Settings on Optimal Staffing Levels

Diana Trutschel, Maryam Ahmadi Shad, Michael Ketzer, Jack Kuipers, Giusi Moffa, Michael Simon



Real-time predictions of bed occupancy in hospitals.

Ensor Rafael Palacios, Theresa Smith



Positive and negative predictive values of diagnostic tests using area under the curve

Kanae Takahashi, Kouji Yamamoto



Freely accessible software for recruitment prediction and recruitment monitoring: Is it necessary?

Philip Heesen, Manuela Ott, Katarina Zatkova, Malgorzata Roos



On moderation in a Bayesian log-contrast compositional model with a total. Interaction between extreme temperatures and pollutants on mortality

Germá Coenders, Javier Palarea-Albadalejo, Marc Saez, Maria A. Barceló



Graphical inference in nonparametric hypothesis testing: A two-dimensional grid framework for analysis and visualization

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



On regression analysis of interval-valued data based on order statistics

Ryo Mizushima, Asanao Shimokawa



Two-sided Beyesian simultaneous credible bands in linear regression model

Fei Yang



Cell composition analysis with unmeasured confounding

Amber Huybrechts, Koen Van den Berge, Sanne Roels, Oliver Dukes



Temporal transcriptomic analysis of microexon alternative splicing in mouse neurodevelopmental genes

Jimin Kim, Kwanghoon Cho, Jahyun Yun, Dayeon Kang



A Robust Method for Accurate Reconstruction of 3D Genome Conformation from Hi-C Data

Insu Jang, MInsu Park



Balancing Accuracy, Clinical Utility, and Explainability: A Machine Learning Approach to Prostate Cancer Prediction

Luis Mariano Esteban, Rocío Aznar, Angel Borque-Fernando, Alejandro Camón, Patricia Guerrero



Development of a thyroid cancer recurrence prediction calculator: A regression approach

Jiaxu Zeng



A comparison of methods for modelling multi-state cancer progression using screening data with censoring after intervention

Eddymurphy U. Akwiwu, Veerle M.H. Coupé, Johannes Berkhof, Thomas Klausch



ADHD and 10–Year Disease Progression from Initiating Pharmacotherapy for Hypertension to Death: A Multistate Modelling Analysis

Yiling Zhou, Douwe Postmus, Anne van Lammeren, Casper F.M. Franssen, Harold Snieder, Catharina A. Hartman



Understanding PSA Dynamics: Integrating Longitudinal Trajectories, Testing Patterns, and Disease Progression.

Birzhan Akynkozhayev, Benjamin Christoffersen, Mark Clements



Joint Modeling for Principal Stratification: Analyzing Stroke Events in CADASIL Patients Across NOTCH3 Variants

Léa Aguilhon, Sophie Tezenas du Montcel, Juliette Ortholand



Challenges in modelling neuropsychiatric symptoms in early Alzheimer's Disease

Rachid Abbas



Network models to decipher the Human exposome : application to food exposome patterns in the general population

Ima Bernada, Gregory Nuel, Cécilia Samieri



Study brain connectivity changes in Dementia with Lewy Bodies with Functional Conditional Gaussian Graphical Models

Alessia Mapelli, Laura Carini, Michela Carlotta Massi, Dario Arnaldi, Emanuele Di Angelantonio, Francesca Ieva, Sara Sommariva



LongiSurvSHAP: Explaining Survival Models with Longitudinal Features

Van Tuan NGUYEN, Lucas Ducrot, Agathe Guilloux



Prognostic Models for Recurrent Event Data

Victoria Watson, Laura Bonnett, Catrin Tudur-Smith



Unlocking diagnosis code for longitudinal modeling through representations from large language models

Fabian Kabus, Maren Hackenberg, Moritz Hess, Simon Ging, Maryam Farhadizadeh, Nadine Binder, Harald Binder



Machine Learning Perspectives in Survival Prediction Model Selection: Frequentist vs. Bayesian Approach

Emanuele Koumantakis, Valentina Bonuomo, Selene Grano, Fausto Castagnetti, Carlo Gambacorti-Passerini, Massimo Breccia, Maria Cristina Miggiano, Chiara Elena, Matteo Pacilli, Isabella Capodanno, Tamara Intermesoli, Monica Bocchia, Alessandra Iurlo, Fabio Ciceri, Fabrizio Pane, Federica Sorà, Barbara Scappini, Angelo Michele Carella, Elisabetta Abruzzese, Sara Galimberti, Sabrina Leonetti Crescenzi, Marco de Gobbi, Giuseppe Saglio, Daniela Cilloni, Carmen Fava, Paola Berchialla



Non-parametric methods for comparing survival functions with censored data: Exhaustive simulation of all possible beyond-observed censoring scenarios and computational analysis

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



Tree-based methods for length-biased survival data

Jinwoo Lee, Jiyu Sun, Donghwan Lee



Evaluating different pragmatic approaches for selecting the truncation time of the restricted mean survival time in randomized controlled trials

Léa Orsini, Andres Cardona, Emmanuel Lesaffre, David Dejardin, Gwénaël Le Teuff



Identifying risk factors for hospital readmission in home-based care: a study from a monographic paediatric cancer centre

Sara Perez-Jaume, Maria Antònia Colomar-Riutort, Anna Felip-Badia, Maria Fabregat, Laura Andrés-Zallo



A web-application for predicting Serious Adverse Event for guiding the enrollment procedure in Clinical Trials with Machine Learning Methods

Ajsi Kanapari, Corrado Lanera, Dario Gregori



Assessing the Overall Burden of Adverse Events in Clinical Trials: Approaches and Challenges

Seid Hamzic, Hans-Joachim Helms, Eva Rossman, Robert Walls



Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base

Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud



Information borrowing in phase II randomized dose-ranging clinical trials in oncology

Guillaume Mulier, Vincent Lévy, Lucie Biard



Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior

Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo



A Bayesian approach to decision making in early development clinical trials : An R solution.

Audrey Te-ying Yeo



Designing Clinical Trials in R with rpact and crmPack

Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke



Leveraging on historical controls in the design and analysis of phase II clinical trials

Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai



Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format

Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev



Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software

Yannick Vandendijck, Christina Fillmore, Lyn Taylor



Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation

Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao



Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes

Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel



CUtools: an R package for clinical utility analysis of predictive models

María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando



Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand

Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian



Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period

Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban



The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response

Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson



Topic modelling and time-series analysis to explore methodological trend evolution

Gabrielle Gauthier-Gagné, Tibor Schuster



Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments

Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell



Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial

Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare



Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand

Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John



Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data

Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri



An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics

Christos Christogiannis, Dimitris Mavridis



Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study

Corentin Choisy, Yseulys Dubuy, Véronique Sébille



Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example

Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales



Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study

Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen



Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS)

Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch



Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods

Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra



Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies

Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White



A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments

Kotaro Sasaki, Hisashi Noma



Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol

Nadia Dardenne, Anh Diep, Anne-Françoise Donneau



Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency

Mi Mi Ko



Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width

Paul Talsma, Francesco Innocenti



Sample size calculation methods for clinical trials using co-primary count endpoints

Takuma Ishihara, Kouji Yamamoto



Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials

Hao Jiang, Yonghong Gao



Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes

Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata



Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics

Lucie Fayette, Karl Brendel, France Mentré



Unbiased Estimation for Hierarchical Models in Clinical Trials

Raiann Joanna Hamshaw, Nanxuan Lin



Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma

Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann



Bayesian bivariate analysis of phase II basket trials enabling borrowing of information

Zhi Cao, Pavel Mozgunov, Haiyan Zheng



Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod

Yuki Fukuyama, Gosuke Homma, Masahiko Gosho



Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables

Vanessa Ihl, Ralf-Dieter Hilgers



Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach

Eisuke Hida, Satomi Okamura, Tomoharu Sato



Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study

Wenyue Li, Becky Turner, Duncan Gilbert, Ian White



Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials.

Teresa Engelbrecht, Alexandra Graf



A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions

Monika Jelizarow



Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials

Tomoharu Sato, Eisuke Hida



Dealing with missing values in adaptive N-of-1 trials

Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski



Adaptive clinical trial design with delayed treatment effects using elicited prior distributions

James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson

2:00pm
-
3:30pm
Poster Exhibition: M / Monday posters
Location: Poster Location
 

Longitudinal Psychological Status and Risk of Major Cardiovascular Events (MCE) in Individuals with Pre-Existing Myocardial Infarction: A Joint Modeling Approach

Nasrin Salimian, Marjan Mansourian, Masoumeh Sadeghi, Hamidreza Roohafza, Hamid Reza Marateb



Cardio-metabolic traits and its socioeconomic differentials among school children including MONW phenotypes in India: A baseline characteristics of LEAP-C cohort

Kalaivani Mani, Chitralok Hemraj, Varhlunchhungi Varhlunchhungi, Lakshmy Ramakrishnan, Sumit Malhotra, Sanjeev Kumar Gupta, Raman Kumar Marwaha, Ransi Ann Abraham, Monika Arora, Tina Rawal, Maroof Ahmad Khan, Aditi Sinha, Nikhil Tandon



External validation of SMART2 model for recurrent cardiovascular risk

Jasper Wilhelmus Adrianus van Egeraat, Nan van Geloven, Hendrikus van Os



Multi-disease risk models to target concomitant diseases and their interactions: Insights on cardio-renal-metabolic syndrome in England

Stelios Boulitsakis Logothetis, Niels Peek, Angela Wood



Machine learning methods for analyzing longitudinal health data streams: A comparative study

Inês Sousa



Evaluating the fairness of a clinical prediction model for outcomes following psychological treatment in the UK’s National Health Service

Nour Kanso, Thalia C. Eley, Ewan Carr



Multiple Imputation vs. Machine Learning for Handling Missing Data in Prediction Modelling: Which Best Balances Stability, Performance, and Computational Efficiency?

Pakpoom Wongyikul, Phichayut Phinyo, Noraworn jirattikanwong, Natthanaphop Isaradech, Wachiranun Sirikul, Arintaya Phrommintikul



Estimating rates of dental treatment and unmet dental need in a spatially explicit model in children in England, 2016-2018

Beatrice Catherine Downing



Statistical Approach to Assess the Impact of Hospital Settings on Optimal Staffing Levels

Diana Trutschel, Maryam Ahmadi Shad, Michael Ketzer, Jack Kuipers, Giusi Moffa, Michael Simon



Real-time predictions of bed occupancy in hospitals.

Ensor Rafael Palacios, Theresa Smith



Positive and negative predictive values of diagnostic tests using area under the curve

Kanae Takahashi, Kouji Yamamoto



Freely accessible software for recruitment prediction and recruitment monitoring: Is it necessary?

Philip Heesen, Manuela Ott, Katarina Zatkova, Malgorzata Roos



On moderation in a Bayesian log-contrast compositional model with a total. Interaction between extreme temperatures and pollutants on mortality

Germá Coenders, Javier Palarea-Albadalejo, Marc Saez, Maria A. Barceló



Graphical inference in nonparametric hypothesis testing: A two-dimensional grid framework for analysis and visualization

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



On regression analysis of interval-valued data based on order statistics

Ryo Mizushima, Asanao Shimokawa



Two-sided Beyesian simultaneous credible bands in linear regression model

Fei Yang



Cell composition analysis with unmeasured confounding

Amber Huybrechts, Koen Van den Berge, Sanne Roels, Oliver Dukes



Temporal transcriptomic analysis of microexon alternative splicing in mouse neurodevelopmental genes

Jimin Kim, Kwanghoon Cho, Jahyun Yun, Dayeon Kang



A Robust Method for Accurate Reconstruction of 3D Genome Conformation from Hi-C Data

Insu Jang, MInsu Park



Balancing Accuracy, Clinical Utility, and Explainability: A Machine Learning Approach to Prostate Cancer Prediction

Luis Mariano Esteban, Rocío Aznar, Angel Borque-Fernando, Alejandro Camón, Patricia Guerrero



Development of a thyroid cancer recurrence prediction calculator: A regression approach

Jiaxu Zeng



A comparison of methods for modelling multi-state cancer progression using screening data with censoring after intervention

Eddymurphy U. Akwiwu, Veerle M.H. Coupé, Johannes Berkhof, Thomas Klausch



ADHD and 10–Year Disease Progression from Initiating Pharmacotherapy for Hypertension to Death: A Multistate Modelling Analysis

Yiling Zhou, Douwe Postmus, Anne van Lammeren, Casper F.M. Franssen, Harold Snieder, Catharina A. Hartman



Understanding PSA Dynamics: Integrating Longitudinal Trajectories, Testing Patterns, and Disease Progression.

Birzhan Akynkozhayev, Benjamin Christoffersen, Mark Clements



Joint Modeling for Principal Stratification: Analyzing Stroke Events in CADASIL Patients Across NOTCH3 Variants

Léa Aguilhon, Sophie Tezenas du Montcel, Juliette Ortholand



Challenges in modelling neuropsychiatric symptoms in early Alzheimer's Disease

Rachid Abbas



Network models to decipher the Human exposome : application to food exposome patterns in the general population

Ima Bernada, Gregory Nuel, Cécilia Samieri



Study brain connectivity changes in Dementia with Lewy Bodies with Functional Conditional Gaussian Graphical Models

Alessia Mapelli, Laura Carini, Michela Carlotta Massi, Dario Arnaldi, Emanuele Di Angelantonio, Francesca Ieva, Sara Sommariva



LongiSurvSHAP: Explaining Survival Models with Longitudinal Features

Van Tuan NGUYEN, Lucas Ducrot, Agathe Guilloux



Prognostic Models for Recurrent Event Data

Victoria Watson, Laura Bonnett, Catrin Tudur-Smith



Unlocking diagnosis code for longitudinal modeling through representations from large language models

Fabian Kabus, Maren Hackenberg, Moritz Hess, Simon Ging, Maryam Farhadizadeh, Nadine Binder, Harald Binder



Machine Learning Perspectives in Survival Prediction Model Selection: Frequentist vs. Bayesian Approach

Emanuele Koumantakis, Valentina Bonuomo, Selene Grano, Fausto Castagnetti, Carlo Gambacorti-Passerini, Massimo Breccia, Maria Cristina Miggiano, Chiara Elena, Matteo Pacilli, Isabella Capodanno, Tamara Intermesoli, Monica Bocchia, Alessandra Iurlo, Fabio Ciceri, Fabrizio Pane, Federica Sorà, Barbara Scappini, Angelo Michele Carella, Elisabetta Abruzzese, Sara Galimberti, Sabrina Leonetti Crescenzi, Marco de Gobbi, Giuseppe Saglio, Daniela Cilloni, Carmen Fava, Paola Berchialla



Non-parametric methods for comparing survival functions with censored data: Exhaustive simulation of all possible beyond-observed censoring scenarios and computational analysis

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



Tree-based methods for length-biased survival data

Jinwoo Lee, Jiyu Sun, Donghwan Lee



Evaluating different pragmatic approaches for selecting the truncation time of the restricted mean survival time in randomized controlled trials

Léa Orsini, Andres Cardona, Emmanuel Lesaffre, David Dejardin, Gwénaël Le Teuff



Identifying risk factors for hospital readmission in home-based care: a study from a monographic paediatric cancer centre

Sara Perez-Jaume, Maria Antònia Colomar-Riutort, Anna Felip-Badia, Maria Fabregat, Laura Andrés-Zallo



A web-application for predicting Serious Adverse Event for guiding the enrollment procedure in Clinical Trials with Machine Learning Methods

Ajsi Kanapari, Corrado Lanera, Dario Gregori



Assessing the Overall Burden of Adverse Events in Clinical Trials: Approaches and Challenges

Seid Hamzic, Hans-Joachim Helms, Eva Rossman, Robert Walls



Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base

Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud



Information borrowing in phase II randomized dose-ranging clinical trials in oncology

Guillaume Mulier, Vincent Lévy, Lucie Biard



Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior

Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo



A Bayesian approach to decision making in early development clinical trials : An R solution.

Audrey Te-ying Yeo



Designing Clinical Trials in R with rpact and crmPack

Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke



Leveraging on historical controls in the design and analysis of phase II clinical trials

Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai



Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format

Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev



Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software

Yannick Vandendijck, Christina Fillmore, Lyn Taylor



Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation

Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao



Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes

Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel



CUtools: an R package for clinical utility analysis of predictive models

María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando



Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand

Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian



Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period

Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban



The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response

Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson



Topic modelling and time-series analysis to explore methodological trend evolution

Gabrielle Gauthier-Gagné, Tibor Schuster



Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments

Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell



Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial

Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare



Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand

Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John



Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data

Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri



An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics

Christos Christogiannis, Dimitris Mavridis



Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study

Corentin Choisy, Yseulys Dubuy, Véronique Sébille



Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example

Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales



Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study

Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen



Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS)

Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch



Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods

Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra



Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies

Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White



A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments

Kotaro Sasaki, Hisashi Noma



Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol

Nadia Dardenne, Anh Diep, Anne-Françoise Donneau



Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency

Mi Mi Ko



Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width

Paul Talsma, Francesco Innocenti



Sample size calculation methods for clinical trials using co-primary count endpoints

Takuma Ishihara, Kouji Yamamoto



Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials

Hao Jiang, Yonghong Gao



Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes

Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata



Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics

Lucie Fayette, Karl Brendel, France Mentré



Unbiased Estimation for Hierarchical Models in Clinical Trials

Raiann Joanna Hamshaw, Nanxuan Lin



Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma

Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann



Bayesian bivariate analysis of phase II basket trials enabling borrowing of information

Zhi Cao, Pavel Mozgunov, Haiyan Zheng



Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod

Yuki Fukuyama, Gosuke Homma, Masahiko Gosho



Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables

Vanessa Ihl, Ralf-Dieter Hilgers



Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach

Eisuke Hida, Satomi Okamura, Tomoharu Sato



Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study

Wenyue Li, Becky Turner, Duncan Gilbert, Ian White



Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials.

Teresa Engelbrecht, Alexandra Graf



A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions

Monika Jelizarow



Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials

Tomoharu Sato, Eisuke Hida



Dealing with missing values in adaptive N-of-1 trials

Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski



Adaptive clinical trial design with delayed treatment effects using elicited prior distributions

James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson

3:30pm
-
4:00pm
Poster Exhibition: M / Monday posters
Location: Poster Location
 

Longitudinal Psychological Status and Risk of Major Cardiovascular Events (MCE) in Individuals with Pre-Existing Myocardial Infarction: A Joint Modeling Approach

Nasrin Salimian, Marjan Mansourian, Masoumeh Sadeghi, Hamidreza Roohafza, Hamid Reza Marateb



Cardio-metabolic traits and its socioeconomic differentials among school children including MONW phenotypes in India: A baseline characteristics of LEAP-C cohort

Kalaivani Mani, Chitralok Hemraj, Varhlunchhungi Varhlunchhungi, Lakshmy Ramakrishnan, Sumit Malhotra, Sanjeev Kumar Gupta, Raman Kumar Marwaha, Ransi Ann Abraham, Monika Arora, Tina Rawal, Maroof Ahmad Khan, Aditi Sinha, Nikhil Tandon



External validation of SMART2 model for recurrent cardiovascular risk

Jasper Wilhelmus Adrianus van Egeraat, Nan van Geloven, Hendrikus van Os



Multi-disease risk models to target concomitant diseases and their interactions: Insights on cardio-renal-metabolic syndrome in England

Stelios Boulitsakis Logothetis, Niels Peek, Angela Wood



Machine learning methods for analyzing longitudinal health data streams: A comparative study

Inês Sousa



Evaluating the fairness of a clinical prediction model for outcomes following psychological treatment in the UK’s National Health Service

Nour Kanso, Thalia C. Eley, Ewan Carr



Multiple Imputation vs. Machine Learning for Handling Missing Data in Prediction Modelling: Which Best Balances Stability, Performance, and Computational Efficiency?

Pakpoom Wongyikul, Phichayut Phinyo, Noraworn jirattikanwong, Natthanaphop Isaradech, Wachiranun Sirikul, Arintaya Phrommintikul



Estimating rates of dental treatment and unmet dental need in a spatially explicit model in children in England, 2016-2018

Beatrice Catherine Downing



Statistical Approach to Assess the Impact of Hospital Settings on Optimal Staffing Levels

Diana Trutschel, Maryam Ahmadi Shad, Michael Ketzer, Jack Kuipers, Giusi Moffa, Michael Simon



Real-time predictions of bed occupancy in hospitals.

Ensor Rafael Palacios, Theresa Smith



Positive and negative predictive values of diagnostic tests using area under the curve

Kanae Takahashi, Kouji Yamamoto



Freely accessible software for recruitment prediction and recruitment monitoring: Is it necessary?

Philip Heesen, Manuela Ott, Katarina Zatkova, Malgorzata Roos



On moderation in a Bayesian log-contrast compositional model with a total. Interaction between extreme temperatures and pollutants on mortality

Germá Coenders, Javier Palarea-Albadalejo, Marc Saez, Maria A. Barceló



Graphical inference in nonparametric hypothesis testing: A two-dimensional grid framework for analysis and visualization

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



On regression analysis of interval-valued data based on order statistics

Ryo Mizushima, Asanao Shimokawa



Two-sided Beyesian simultaneous credible bands in linear regression model

Fei Yang



Cell composition analysis with unmeasured confounding

Amber Huybrechts, Koen Van den Berge, Sanne Roels, Oliver Dukes



Temporal transcriptomic analysis of microexon alternative splicing in mouse neurodevelopmental genes

Jimin Kim, Kwanghoon Cho, Jahyun Yun, Dayeon Kang



A Robust Method for Accurate Reconstruction of 3D Genome Conformation from Hi-C Data

Insu Jang, MInsu Park



Balancing Accuracy, Clinical Utility, and Explainability: A Machine Learning Approach to Prostate Cancer Prediction

Luis Mariano Esteban, Rocío Aznar, Angel Borque-Fernando, Alejandro Camón, Patricia Guerrero



Development of a thyroid cancer recurrence prediction calculator: A regression approach

Jiaxu Zeng



A comparison of methods for modelling multi-state cancer progression using screening data with censoring after intervention

Eddymurphy U. Akwiwu, Veerle M.H. Coupé, Johannes Berkhof, Thomas Klausch



ADHD and 10–Year Disease Progression from Initiating Pharmacotherapy for Hypertension to Death: A Multistate Modelling Analysis

Yiling Zhou, Douwe Postmus, Anne van Lammeren, Casper F.M. Franssen, Harold Snieder, Catharina A. Hartman



Understanding PSA Dynamics: Integrating Longitudinal Trajectories, Testing Patterns, and Disease Progression.

Birzhan Akynkozhayev, Benjamin Christoffersen, Mark Clements



Joint Modeling for Principal Stratification: Analyzing Stroke Events in CADASIL Patients Across NOTCH3 Variants

Léa Aguilhon, Sophie Tezenas du Montcel, Juliette Ortholand



Challenges in modelling neuropsychiatric symptoms in early Alzheimer's Disease

Rachid Abbas



Network models to decipher the Human exposome : application to food exposome patterns in the general population

Ima Bernada, Gregory Nuel, Cécilia Samieri



Study brain connectivity changes in Dementia with Lewy Bodies with Functional Conditional Gaussian Graphical Models

Alessia Mapelli, Laura Carini, Michela Carlotta Massi, Dario Arnaldi, Emanuele Di Angelantonio, Francesca Ieva, Sara Sommariva



LongiSurvSHAP: Explaining Survival Models with Longitudinal Features

Van Tuan NGUYEN, Lucas Ducrot, Agathe Guilloux



Prognostic Models for Recurrent Event Data

Victoria Watson, Laura Bonnett, Catrin Tudur-Smith



Unlocking diagnosis code for longitudinal modeling through representations from large language models

Fabian Kabus, Maren Hackenberg, Moritz Hess, Simon Ging, Maryam Farhadizadeh, Nadine Binder, Harald Binder



Machine Learning Perspectives in Survival Prediction Model Selection: Frequentist vs. Bayesian Approach

Emanuele Koumantakis, Valentina Bonuomo, Selene Grano, Fausto Castagnetti, Carlo Gambacorti-Passerini, Massimo Breccia, Maria Cristina Miggiano, Chiara Elena, Matteo Pacilli, Isabella Capodanno, Tamara Intermesoli, Monica Bocchia, Alessandra Iurlo, Fabio Ciceri, Fabrizio Pane, Federica Sorà, Barbara Scappini, Angelo Michele Carella, Elisabetta Abruzzese, Sara Galimberti, Sabrina Leonetti Crescenzi, Marco de Gobbi, Giuseppe Saglio, Daniela Cilloni, Carmen Fava, Paola Berchialla



Non-parametric methods for comparing survival functions with censored data: Exhaustive simulation of all possible beyond-observed censoring scenarios and computational analysis

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



Tree-based methods for length-biased survival data

Jinwoo Lee, Jiyu Sun, Donghwan Lee



Evaluating different pragmatic approaches for selecting the truncation time of the restricted mean survival time in randomized controlled trials

Léa Orsini, Andres Cardona, Emmanuel Lesaffre, David Dejardin, Gwénaël Le Teuff



Identifying risk factors for hospital readmission in home-based care: a study from a monographic paediatric cancer centre

Sara Perez-Jaume, Maria Antònia Colomar-Riutort, Anna Felip-Badia, Maria Fabregat, Laura Andrés-Zallo



A web-application for predicting Serious Adverse Event for guiding the enrollment procedure in Clinical Trials with Machine Learning Methods

Ajsi Kanapari, Corrado Lanera, Dario Gregori



Assessing the Overall Burden of Adverse Events in Clinical Trials: Approaches and Challenges

Seid Hamzic, Hans-Joachim Helms, Eva Rossman, Robert Walls



Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base

Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud



Information borrowing in phase II randomized dose-ranging clinical trials in oncology

Guillaume Mulier, Vincent Lévy, Lucie Biard



Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior

Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo



A Bayesian approach to decision making in early development clinical trials : An R solution.

Audrey Te-ying Yeo



Designing Clinical Trials in R with rpact and crmPack

Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke



Leveraging on historical controls in the design and analysis of phase II clinical trials

Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai



Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format

Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev



Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software

Yannick Vandendijck, Christina Fillmore, Lyn Taylor



Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation

Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao



Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes

Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel



CUtools: an R package for clinical utility analysis of predictive models

María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando



Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand

Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian



Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period

Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban



The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response

Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson



Topic modelling and time-series analysis to explore methodological trend evolution

Gabrielle Gauthier-Gagné, Tibor Schuster



Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments

Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell



Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial

Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare



Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand

Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John



Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data

Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri



An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics

Christos Christogiannis, Dimitris Mavridis



Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study

Corentin Choisy, Yseulys Dubuy, Véronique Sébille



Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example

Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales



Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study

Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen



Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS)

Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch



Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods

Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra



Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies

Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White



A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments

Kotaro Sasaki, Hisashi Noma



Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol

Nadia Dardenne, Anh Diep, Anne-Françoise Donneau



Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency

Mi Mi Ko



Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width

Paul Talsma, Francesco Innocenti



Sample size calculation methods for clinical trials using co-primary count endpoints

Takuma Ishihara, Kouji Yamamoto



Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials

Hao Jiang, Yonghong Gao



Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes

Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata



Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics

Lucie Fayette, Karl Brendel, France Mentré



Unbiased Estimation for Hierarchical Models in Clinical Trials

Raiann Joanna Hamshaw, Nanxuan Lin



Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma

Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann



Bayesian bivariate analysis of phase II basket trials enabling borrowing of information

Zhi Cao, Pavel Mozgunov, Haiyan Zheng



Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod

Yuki Fukuyama, Gosuke Homma, Masahiko Gosho



Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables

Vanessa Ihl, Ralf-Dieter Hilgers



Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach

Eisuke Hida, Satomi Okamura, Tomoharu Sato



Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study

Wenyue Li, Becky Turner, Duncan Gilbert, Ian White



Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials.

Teresa Engelbrecht, Alexandra Graf



A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions

Monika Jelizarow



Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials

Tomoharu Sato, Eisuke Hida



Dealing with missing values in adaptive N-of-1 trials

Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski



Adaptive clinical trial design with delayed treatment effects using elicited prior distributions

James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson

4:00pm
-
5:30pm
Poster Exhibition: M / Monday posters
Location: Poster Location
 

Longitudinal Psychological Status and Risk of Major Cardiovascular Events (MCE) in Individuals with Pre-Existing Myocardial Infarction: A Joint Modeling Approach

Nasrin Salimian, Marjan Mansourian, Masoumeh Sadeghi, Hamidreza Roohafza, Hamid Reza Marateb



Cardio-metabolic traits and its socioeconomic differentials among school children including MONW phenotypes in India: A baseline characteristics of LEAP-C cohort

Kalaivani Mani, Chitralok Hemraj, Varhlunchhungi Varhlunchhungi, Lakshmy Ramakrishnan, Sumit Malhotra, Sanjeev Kumar Gupta, Raman Kumar Marwaha, Ransi Ann Abraham, Monika Arora, Tina Rawal, Maroof Ahmad Khan, Aditi Sinha, Nikhil Tandon



External validation of SMART2 model for recurrent cardiovascular risk

Jasper Wilhelmus Adrianus van Egeraat, Nan van Geloven, Hendrikus van Os



Multi-disease risk models to target concomitant diseases and their interactions: Insights on cardio-renal-metabolic syndrome in England

Stelios Boulitsakis Logothetis, Niels Peek, Angela Wood



Machine learning methods for analyzing longitudinal health data streams: A comparative study

Inês Sousa



Evaluating the fairness of a clinical prediction model for outcomes following psychological treatment in the UK’s National Health Service

Nour Kanso, Thalia C. Eley, Ewan Carr



Multiple Imputation vs. Machine Learning for Handling Missing Data in Prediction Modelling: Which Best Balances Stability, Performance, and Computational Efficiency?

Pakpoom Wongyikul, Phichayut Phinyo, Noraworn jirattikanwong, Natthanaphop Isaradech, Wachiranun Sirikul, Arintaya Phrommintikul



Estimating rates of dental treatment and unmet dental need in a spatially explicit model in children in England, 2016-2018

Beatrice Catherine Downing



Statistical Approach to Assess the Impact of Hospital Settings on Optimal Staffing Levels

Diana Trutschel, Maryam Ahmadi Shad, Michael Ketzer, Jack Kuipers, Giusi Moffa, Michael Simon



Real-time predictions of bed occupancy in hospitals.

Ensor Rafael Palacios, Theresa Smith



Positive and negative predictive values of diagnostic tests using area under the curve

Kanae Takahashi, Kouji Yamamoto



Freely accessible software for recruitment prediction and recruitment monitoring: Is it necessary?

Philip Heesen, Manuela Ott, Katarina Zatkova, Malgorzata Roos



On moderation in a Bayesian log-contrast compositional model with a total. Interaction between extreme temperatures and pollutants on mortality

Germá Coenders, Javier Palarea-Albadalejo, Marc Saez, Maria A. Barceló



Graphical inference in nonparametric hypothesis testing: A two-dimensional grid framework for analysis and visualization

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



On regression analysis of interval-valued data based on order statistics

Ryo Mizushima, Asanao Shimokawa



Two-sided Beyesian simultaneous credible bands in linear regression model

Fei Yang



Cell composition analysis with unmeasured confounding

Amber Huybrechts, Koen Van den Berge, Sanne Roels, Oliver Dukes



Temporal transcriptomic analysis of microexon alternative splicing in mouse neurodevelopmental genes

Jimin Kim, Kwanghoon Cho, Jahyun Yun, Dayeon Kang



A Robust Method for Accurate Reconstruction of 3D Genome Conformation from Hi-C Data

Insu Jang, MInsu Park



Balancing Accuracy, Clinical Utility, and Explainability: A Machine Learning Approach to Prostate Cancer Prediction

Luis Mariano Esteban, Rocío Aznar, Angel Borque-Fernando, Alejandro Camón, Patricia Guerrero



Development of a thyroid cancer recurrence prediction calculator: A regression approach

Jiaxu Zeng



A comparison of methods for modelling multi-state cancer progression using screening data with censoring after intervention

Eddymurphy U. Akwiwu, Veerle M.H. Coupé, Johannes Berkhof, Thomas Klausch



ADHD and 10–Year Disease Progression from Initiating Pharmacotherapy for Hypertension to Death: A Multistate Modelling Analysis

Yiling Zhou, Douwe Postmus, Anne van Lammeren, Casper F.M. Franssen, Harold Snieder, Catharina A. Hartman



Understanding PSA Dynamics: Integrating Longitudinal Trajectories, Testing Patterns, and Disease Progression.

Birzhan Akynkozhayev, Benjamin Christoffersen, Mark Clements



Joint Modeling for Principal Stratification: Analyzing Stroke Events in CADASIL Patients Across NOTCH3 Variants

Léa Aguilhon, Sophie Tezenas du Montcel, Juliette Ortholand



Challenges in modelling neuropsychiatric symptoms in early Alzheimer's Disease

Rachid Abbas



Network models to decipher the Human exposome : application to food exposome patterns in the general population

Ima Bernada, Gregory Nuel, Cécilia Samieri



Study brain connectivity changes in Dementia with Lewy Bodies with Functional Conditional Gaussian Graphical Models

Alessia Mapelli, Laura Carini, Michela Carlotta Massi, Dario Arnaldi, Emanuele Di Angelantonio, Francesca Ieva, Sara Sommariva



LongiSurvSHAP: Explaining Survival Models with Longitudinal Features

Van Tuan NGUYEN, Lucas Ducrot, Agathe Guilloux



Prognostic Models for Recurrent Event Data

Victoria Watson, Laura Bonnett, Catrin Tudur-Smith



Unlocking diagnosis code for longitudinal modeling through representations from large language models

Fabian Kabus, Maren Hackenberg, Moritz Hess, Simon Ging, Maryam Farhadizadeh, Nadine Binder, Harald Binder



Machine Learning Perspectives in Survival Prediction Model Selection: Frequentist vs. Bayesian Approach

Emanuele Koumantakis, Valentina Bonuomo, Selene Grano, Fausto Castagnetti, Carlo Gambacorti-Passerini, Massimo Breccia, Maria Cristina Miggiano, Chiara Elena, Matteo Pacilli, Isabella Capodanno, Tamara Intermesoli, Monica Bocchia, Alessandra Iurlo, Fabio Ciceri, Fabrizio Pane, Federica Sorà, Barbara Scappini, Angelo Michele Carella, Elisabetta Abruzzese, Sara Galimberti, Sabrina Leonetti Crescenzi, Marco de Gobbi, Giuseppe Saglio, Daniela Cilloni, Carmen Fava, Paola Berchialla



Non-parametric methods for comparing survival functions with censored data: Exhaustive simulation of all possible beyond-observed censoring scenarios and computational analysis

Lubomír Štěpánek, Ondřej Vít, Lubomír Seif



Tree-based methods for length-biased survival data

Jinwoo Lee, Jiyu Sun, Donghwan Lee



Evaluating different pragmatic approaches for selecting the truncation time of the restricted mean survival time in randomized controlled trials

Léa Orsini, Andres Cardona, Emmanuel Lesaffre, David Dejardin, Gwénaël Le Teuff



Identifying risk factors for hospital readmission in home-based care: a study from a monographic paediatric cancer centre

Sara Perez-Jaume, Maria Antònia Colomar-Riutort, Anna Felip-Badia, Maria Fabregat, Laura Andrés-Zallo



A web-application for predicting Serious Adverse Event for guiding the enrollment procedure in Clinical Trials with Machine Learning Methods

Ajsi Kanapari, Corrado Lanera, Dario Gregori



Assessing the Overall Burden of Adverse Events in Clinical Trials: Approaches and Challenges

Seid Hamzic, Hans-Joachim Helms, Eva Rossman, Robert Walls



Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base

Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud



Information borrowing in phase II randomized dose-ranging clinical trials in oncology

Guillaume Mulier, Vincent Lévy, Lucie Biard



Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior

Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo



A Bayesian approach to decision making in early development clinical trials : An R solution.

Audrey Te-ying Yeo



Designing Clinical Trials in R with rpact and crmPack

Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke



Leveraging on historical controls in the design and analysis of phase II clinical trials

Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai



Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format

Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev



Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software

Yannick Vandendijck, Christina Fillmore, Lyn Taylor



Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation

Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao



Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes

Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel



CUtools: an R package for clinical utility analysis of predictive models

María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando



Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand

Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian



Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period

Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban



The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response

Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson



Topic modelling and time-series analysis to explore methodological trend evolution

Gabrielle Gauthier-Gagné, Tibor Schuster



Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments

Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell



Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial

Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare



Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand

Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John



Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data

Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri



An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics

Christos Christogiannis, Dimitris Mavridis



Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study

Corentin Choisy, Yseulys Dubuy, Véronique Sébille



Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example

Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales



Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study

Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen



Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS)

Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch



Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods

Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra



Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies

Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White



A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments

Kotaro Sasaki, Hisashi Noma



Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol

Nadia Dardenne, Anh Diep, Anne-Françoise Donneau



Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency

Mi Mi Ko



Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width

Paul Talsma, Francesco Innocenti



Sample size calculation methods for clinical trials using co-primary count endpoints

Takuma Ishihara, Kouji Yamamoto



Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials

Hao Jiang, Yonghong Gao



Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes

Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata



Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics

Lucie Fayette, Karl Brendel, France Mentré



Unbiased Estimation for Hierarchical Models in Clinical Trials

Raiann Joanna Hamshaw, Nanxuan Lin



Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma

Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann



Bayesian bivariate analysis of phase II basket trials enabling borrowing of information

Zhi Cao, Pavel Mozgunov, Haiyan Zheng



Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod

Yuki Fukuyama, Gosuke Homma, Masahiko Gosho



Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables

Vanessa Ihl, Ralf-Dieter Hilgers



Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach

Eisuke Hida, Satomi Okamura, Tomoharu Sato



Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study

Wenyue Li, Becky Turner, Duncan Gilbert, Ian White



Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials.

Teresa Engelbrecht, Alexandra Graf



A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions

Monika Jelizarow



Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials

Tomoharu Sato, Eisuke Hida



Dealing with missing values in adaptive N-of-1 trials

Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski



Adaptive clinical trial design with delayed treatment effects using elicited prior distributions

James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson

Date: Tuesday, 26/Aug/2025
8:45am
-
9:15am
Poster Exhibition: T / Tuesday posters
Location: Poster Location
 

Leveraging Wearable data for Probabilistic Imputation in Cardiovascular Risk Calculators.

Antoine Faul, Patric Wyss, Anja Mühlemann, Manuela Moraru, Danielle Bower, Petra Stute, Ben Spycher, David Ginsbourger



Stepwise Prediction of Tuberculosis Treatment Outcomes Using XGBoost and Feature-Level Analysis: A Multi-Stage Approach to Clinical Decision Support

Linfeng Wang, Jody Phelan, Taane Clark



The use of variable selection in clinical prediction modelling for binary outcomes: a systematic review

Xinrui Su, Gareth Ambler, Nathan Green, Menelaos Pavlou



Comparison of Methods for Incorporating Related Data when Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen Martin, David Jenkins



A Systematic Review of Methodological Research on Multi-State Prediction Models

Chantelle Cornett, Glen Martin, Alexander Pate, Victoria Palin



Assessing the robustness of prediction models: A case study on in-hospital mortality prediction using MIMIC-III and MIMIC-IV

Alan Balendran, Raphaël Porcher



The Influence of Variable Selection Approaches on Prediction Model Stability in Low-Dimensional Data: From Traditional Stepwise Selection to Regularisation techniques

Noraworn Jirattikanwong, Phichayut Phinyo, Pakpoom Wongyikul, Natthanaphop Isaradech, Wachiranun Sirikul, Wuttipat Kiratipaisarl



Early-detection of high-risk patient profiles admitted to hospital with respiratory infections using a multistate model

João Pedro Carmezim, Cristian Tebé, Natàlia Pallarès, Roger Paredes, Cavan Reilly



Investigating fair data acquisition for risk prediction in resource-constrained settings

Ioanna Thoma, Matthew Sperrin, Karla Diaz Ordaz, Ricardo Silva, Brieuc Lehmann



A critical benchmark of Bayesian shrinkage estimation for subgroup analysis

Sebastian Weber, Björn Bornkamp, David Ohlssen



Mathematical Modelling of Oxygenation Dynamics Using High-Resolution Perfusion Data: An Advanced Statistical Framework for Understanding Oxygen Metabolism

Mansour Taghavi Azar Sharabiani, Alireza Mahani, Richard Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica



Marginal structural Cox model with weighted cumulative exposure modelling for the estimation of counterfactual Population Attributable Fractions

Yue Zhai, Ana-Maria Vilcu, Jacques Benichou, Lucas Morin, Agnès Fournier, Anne Thiébaut, Vivian Viallon



Lost in the Forest of Forest Plots? Practical Guidelines and an All-in-One Tool for Forest Plots

Hongqiu Gu, Yong Jiang, Hao Li



Robust Outlier Detection with Skewness-Adjusted Fences: Theoretical Foundations and Applications

YUNCHAE JUNG, MINSU PARK



Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles in Linear Regression: An Application to Estimating Shelf Life

Lingjiao Wang, Yang Han, Wei Liu, Frank Bretz



One-sided simultaneous tolerance intervals based on kernel density estimates

Gian Louisse Roy



Robust large-scale multiple testing for hidden Markov random field model

Donghwan Lee, Jiyn Sun



Model informed assurance approach for 3-way PK similarity studies

Rachid El Galta, Roland Baumgartner



Korea Sequence Read Archive (KRA) - A public repository for archiving raw sequence data

JAEHO LEE



Integrative analysis of transcriptomic and epigenomic dynamics of liver organoids using single cell RNA-seq and ATAC-seq

Kwang Hoon Cho, Jong-Hwan Kim, Jimin Kim, Jahyun Yun, Dayeon Kang



Leveraging tumor imaging compositional data structure in model feature space for predicting recurrence in colorectal carcinoma

Olivia J Bobek, Nicholas Larson, Rish K Pai, Fang-Shu Ou



BayesPIM: A Bayesian Prevalence-Incidence Mixture Model for Screening Outcomes, with an Application to Colorectal Cancer

Thomas Klausch, Birgit Lissenberg-Witte, Veerle Coupé



Joint Modelling of Random Heterogeneity in Longitudinal and Multiple time-to-Events in Colon Cancer

DIVYA DENNIS, Jagathnath Krishna KM



Refining the Association between BMI, Waist Circumference, and Breast Cancer Risk in Postmenopausal Women using G-formula Method

Somin Jeon, Boyoung Park, Junghyun Yoon



Building cancer risk prediction models by synthesizing national registry and prevention trial data

Oksana Chernova, Donna Ankerst, Ruth M Pfeiffer



Modelling Individual-level Uncertainty from Missing Data in Personalised Breast Cancer Risk Prediction

Bethan L. White, Lorenzo Ficorella, Xin Yang, Douglas F. Easton, Antonis C. Antoniou



Time-varying covariates in Survival Analysis: a graphical approach to assessing the risk of cardiovascular events and aortic valve sclerosis development

Arianna Galotta, Francesco Maria Mattio, Veronika Myasoedova, Elisabetta Salvioni, Paolo Poggio, Piergiuseppe Agostoni, Alice Bonomi



Polygenic scores as tools for intervention selection in the setting of finasteride for prostate cancer prevention

Allison Meisner



Implementation of a Disease Progression Model accounting for covariates

Gabrielle Casimiro, Sofia Kaisaridi, Sophie Tezenas du Montcel



Genetics influences LDL-C response to statin therapy: short- and long-term observational study with functional data analysis

Andrea Corbetta, Emanuele Di Angelantonio, Andrea Ganna, Francesca Ieva



Longitudinal analysis of imprecise disease status using latent Markov models: application to Italian Thyroid Cancer Observatory data

Silvia D'Elia, Marco Alfò, Maria Francesca Marino



Long-term risk prediction from short-term data – a microsimulation approach

Moritz Pamminger, Theresa Ullmann, Moritz Madern, Daniela Dunkler, Georg Heinze



Deep learning algorithm for dynamic survival prediction with competitive risks

Tristan Margaté, Marine Zulian, Agathe Guilloux, Sandrine Katsahian



Identifying Cutoff in Predictors in Survival Analysis: An Ensemble Strategy for Flexible Knot Selection

Stefania Lando, Giulia Lorenzoni, Dario Gregori



Estimating Quality Adjusted Life Years (QALYs) from a joint modeling framework: a simulation-based study

Vincent Bonnemains, Yohann Foucher, Philippe Tessier, Etienne Dantan



An Alternative Estimand for Overall Survival in the Presence of Treatment Discontinuation: Simulation Results and Case Study

Kara-Louise Royle, David Meads, Jennifer Visser-Rogers, David A Cairns, Ian R White



Corrections of confidence interval for differences in restricted mean survival times in clinical trials with small sample sizes

Hiroya Hashimoto, Akiko Kada



Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry

Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson



Development and validation of prognostic models in phase I oncology clinical trials

Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr



Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint

Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva



Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors

Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux



Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration

Luca Genetti, Andrea Nizzardo, Marco Pergher



Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials

XINGZHI XU, SATOSHI HATTORI



Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints

Go Horiguchi, Isao Yokota, Satoshi Teramukai



Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes

Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap



Estimands in platform trials with time - treatment interactions

ZIYAN WANG, Dave Woods



A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design

Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess



Optimizing Biomarker-Based Enrichment strategies in clinical trials

Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun



Leveraging Synthetic Data for Enhanced Clinical Research Outcomes

Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska



Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL

Byoung Ha Yoon



Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM

Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk



Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models

ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI



Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand

Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian



Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol

Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme



Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards.

Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson



Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models

Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott



Automating Report Generation with Stata: A Case Study of NORUSE

Maria Elstad



Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis.

MOHAMMED ABDU MUDAWI



Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis

Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner



Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes

Mahru Ahmad, Jack Wilkinson, Andy Vail



Causal discovery for multi-cohort studies

Christine Bang, Vanessa Didelez



Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms

A F M Tahsin Shahriar, AHM Mahbub-ul Latif



Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods

Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao



Revisiting subgroup analysis: A reflection on health disparities using conditional independence

Nia Kang, Tibor Schuster



Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study

Jingya Zhao, Gareth Ambler, Baptiste Leurent



Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods.

Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden



Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome

Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz



Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis

Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka



Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative

Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier



Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol

Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango



Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates

Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume



Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial.

Robin Young, Alex McConnachie, Helen Minnis



The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation

Gregory Chen, Micahel Seo, Isaac Gravestock



Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials

Patrick Djidel, Armand Chouzy, Pierre Colin



Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance

Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock



Power calculation using the win-ratio for composite outcomes in randomized trials

David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held



Feasibility of propensity score weighted analysis in rare disease trials: a simulation study

Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini



A basket trial for rare diseases, with a crossover design for its substudies: a simulation study

Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout



Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias

Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets



Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials

Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng



Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials

Anjali Yadav

9:15am
-
10:45am
Poster Exhibition: T / Tuesday posters
Location: Poster Location
 

Leveraging Wearable data for Probabilistic Imputation in Cardiovascular Risk Calculators.

Antoine Faul, Patric Wyss, Anja Mühlemann, Manuela Moraru, Danielle Bower, Petra Stute, Ben Spycher, David Ginsbourger



Stepwise Prediction of Tuberculosis Treatment Outcomes Using XGBoost and Feature-Level Analysis: A Multi-Stage Approach to Clinical Decision Support

Linfeng Wang, Jody Phelan, Taane Clark



The use of variable selection in clinical prediction modelling for binary outcomes: a systematic review

Xinrui Su, Gareth Ambler, Nathan Green, Menelaos Pavlou



Comparison of Methods for Incorporating Related Data when Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen Martin, David Jenkins



A Systematic Review of Methodological Research on Multi-State Prediction Models

Chantelle Cornett, Glen Martin, Alexander Pate, Victoria Palin



Assessing the robustness of prediction models: A case study on in-hospital mortality prediction using MIMIC-III and MIMIC-IV

Alan Balendran, Raphaël Porcher



The Influence of Variable Selection Approaches on Prediction Model Stability in Low-Dimensional Data: From Traditional Stepwise Selection to Regularisation techniques

Noraworn Jirattikanwong, Phichayut Phinyo, Pakpoom Wongyikul, Natthanaphop Isaradech, Wachiranun Sirikul, Wuttipat Kiratipaisarl



Early-detection of high-risk patient profiles admitted to hospital with respiratory infections using a multistate model

João Pedro Carmezim, Cristian Tebé, Natàlia Pallarès, Roger Paredes, Cavan Reilly



Investigating fair data acquisition for risk prediction in resource-constrained settings

Ioanna Thoma, Matthew Sperrin, Karla Diaz Ordaz, Ricardo Silva, Brieuc Lehmann



A critical benchmark of Bayesian shrinkage estimation for subgroup analysis

Sebastian Weber, Björn Bornkamp, David Ohlssen



Mathematical Modelling of Oxygenation Dynamics Using High-Resolution Perfusion Data: An Advanced Statistical Framework for Understanding Oxygen Metabolism

Mansour Taghavi Azar Sharabiani, Alireza Mahani, Richard Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica



Marginal structural Cox model with weighted cumulative exposure modelling for the estimation of counterfactual Population Attributable Fractions

Yue Zhai, Ana-Maria Vilcu, Jacques Benichou, Lucas Morin, Agnès Fournier, Anne Thiébaut, Vivian Viallon



Lost in the Forest of Forest Plots? Practical Guidelines and an All-in-One Tool for Forest Plots

Hongqiu Gu, Yong Jiang, Hao Li



Robust Outlier Detection with Skewness-Adjusted Fences: Theoretical Foundations and Applications

YUNCHAE JUNG, MINSU PARK



Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles in Linear Regression: An Application to Estimating Shelf Life

Lingjiao Wang, Yang Han, Wei Liu, Frank Bretz



One-sided simultaneous tolerance intervals based on kernel density estimates

Gian Louisse Roy



Robust large-scale multiple testing for hidden Markov random field model

Donghwan Lee, Jiyn Sun



Model informed assurance approach for 3-way PK similarity studies

Rachid El Galta, Roland Baumgartner



Korea Sequence Read Archive (KRA) - A public repository for archiving raw sequence data

JAEHO LEE



Integrative analysis of transcriptomic and epigenomic dynamics of liver organoids using single cell RNA-seq and ATAC-seq

Kwang Hoon Cho, Jong-Hwan Kim, Jimin Kim, Jahyun Yun, Dayeon Kang



Leveraging tumor imaging compositional data structure in model feature space for predicting recurrence in colorectal carcinoma

Olivia J Bobek, Nicholas Larson, Rish K Pai, Fang-Shu Ou



BayesPIM: A Bayesian Prevalence-Incidence Mixture Model for Screening Outcomes, with an Application to Colorectal Cancer

Thomas Klausch, Birgit Lissenberg-Witte, Veerle Coupé



Joint Modelling of Random Heterogeneity in Longitudinal and Multiple time-to-Events in Colon Cancer

DIVYA DENNIS, Jagathnath Krishna KM



Refining the Association between BMI, Waist Circumference, and Breast Cancer Risk in Postmenopausal Women using G-formula Method

Somin Jeon, Boyoung Park, Junghyun Yoon



Building cancer risk prediction models by synthesizing national registry and prevention trial data

Oksana Chernova, Donna Ankerst, Ruth M Pfeiffer



Modelling Individual-level Uncertainty from Missing Data in Personalised Breast Cancer Risk Prediction

Bethan L. White, Lorenzo Ficorella, Xin Yang, Douglas F. Easton, Antonis C. Antoniou



Time-varying covariates in Survival Analysis: a graphical approach to assessing the risk of cardiovascular events and aortic valve sclerosis development

Arianna Galotta, Francesco Maria Mattio, Veronika Myasoedova, Elisabetta Salvioni, Paolo Poggio, Piergiuseppe Agostoni, Alice Bonomi



Polygenic scores as tools for intervention selection in the setting of finasteride for prostate cancer prevention

Allison Meisner



Implementation of a Disease Progression Model accounting for covariates

Gabrielle Casimiro, Sofia Kaisaridi, Sophie Tezenas du Montcel



Genetics influences LDL-C response to statin therapy: short- and long-term observational study with functional data analysis

Andrea Corbetta, Emanuele Di Angelantonio, Andrea Ganna, Francesca Ieva



Longitudinal analysis of imprecise disease status using latent Markov models: application to Italian Thyroid Cancer Observatory data

Silvia D'Elia, Marco Alfò, Maria Francesca Marino



Long-term risk prediction from short-term data – a microsimulation approach

Moritz Pamminger, Theresa Ullmann, Moritz Madern, Daniela Dunkler, Georg Heinze



Deep learning algorithm for dynamic survival prediction with competitive risks

Tristan Margaté, Marine Zulian, Agathe Guilloux, Sandrine Katsahian



Identifying Cutoff in Predictors in Survival Analysis: An Ensemble Strategy for Flexible Knot Selection

Stefania Lando, Giulia Lorenzoni, Dario Gregori



Estimating Quality Adjusted Life Years (QALYs) from a joint modeling framework: a simulation-based study

Vincent Bonnemains, Yohann Foucher, Philippe Tessier, Etienne Dantan



An Alternative Estimand for Overall Survival in the Presence of Treatment Discontinuation: Simulation Results and Case Study

Kara-Louise Royle, David Meads, Jennifer Visser-Rogers, David A Cairns, Ian R White



Corrections of confidence interval for differences in restricted mean survival times in clinical trials with small sample sizes

Hiroya Hashimoto, Akiko Kada



Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry

Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson



Development and validation of prognostic models in phase I oncology clinical trials

Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr



Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint

Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva



Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors

Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux



Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration

Luca Genetti, Andrea Nizzardo, Marco Pergher



Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials

XINGZHI XU, SATOSHI HATTORI



Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints

Go Horiguchi, Isao Yokota, Satoshi Teramukai



Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes

Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap



Estimands in platform trials with time - treatment interactions

ZIYAN WANG, Dave Woods



A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design

Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess



Optimizing Biomarker-Based Enrichment strategies in clinical trials

Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun



Leveraging Synthetic Data for Enhanced Clinical Research Outcomes

Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska



Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL

Byoung Ha Yoon



Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM

Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk



Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models

ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI



Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand

Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian



Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol

Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme



Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards.

Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson



Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models

Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott



Automating Report Generation with Stata: A Case Study of NORUSE

Maria Elstad



Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis.

MOHAMMED ABDU MUDAWI



Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis

Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner



Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes

Mahru Ahmad, Jack Wilkinson, Andy Vail



Causal discovery for multi-cohort studies

Christine Bang, Vanessa Didelez



Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms

A F M Tahsin Shahriar, AHM Mahbub-ul Latif



Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods

Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao



Revisiting subgroup analysis: A reflection on health disparities using conditional independence

Nia Kang, Tibor Schuster



Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study

Jingya Zhao, Gareth Ambler, Baptiste Leurent



Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods.

Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden



Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome

Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz



Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis

Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka



Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative

Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier



Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol

Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango



Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates

Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume



Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial.

Robin Young, Alex McConnachie, Helen Minnis



The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation

Gregory Chen, Micahel Seo, Isaac Gravestock



Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials

Patrick Djidel, Armand Chouzy, Pierre Colin



Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance

Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock



Power calculation using the win-ratio for composite outcomes in randomized trials

David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held



Feasibility of propensity score weighted analysis in rare disease trials: a simulation study

Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini



A basket trial for rare diseases, with a crossover design for its substudies: a simulation study

Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout



Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias

Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets



Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials

Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng



Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials

Anjali Yadav

10:45am
-
11:30am
Poster Exhibition: T / Tuesday posters
Location: Poster Location
 

Leveraging Wearable data for Probabilistic Imputation in Cardiovascular Risk Calculators.

Antoine Faul, Patric Wyss, Anja Mühlemann, Manuela Moraru, Danielle Bower, Petra Stute, Ben Spycher, David Ginsbourger



Stepwise Prediction of Tuberculosis Treatment Outcomes Using XGBoost and Feature-Level Analysis: A Multi-Stage Approach to Clinical Decision Support

Linfeng Wang, Jody Phelan, Taane Clark



The use of variable selection in clinical prediction modelling for binary outcomes: a systematic review

Xinrui Su, Gareth Ambler, Nathan Green, Menelaos Pavlou



Comparison of Methods for Incorporating Related Data when Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen Martin, David Jenkins



A Systematic Review of Methodological Research on Multi-State Prediction Models

Chantelle Cornett, Glen Martin, Alexander Pate, Victoria Palin



Assessing the robustness of prediction models: A case study on in-hospital mortality prediction using MIMIC-III and MIMIC-IV

Alan Balendran, Raphaël Porcher



The Influence of Variable Selection Approaches on Prediction Model Stability in Low-Dimensional Data: From Traditional Stepwise Selection to Regularisation techniques

Noraworn Jirattikanwong, Phichayut Phinyo, Pakpoom Wongyikul, Natthanaphop Isaradech, Wachiranun Sirikul, Wuttipat Kiratipaisarl



Early-detection of high-risk patient profiles admitted to hospital with respiratory infections using a multistate model

João Pedro Carmezim, Cristian Tebé, Natàlia Pallarès, Roger Paredes, Cavan Reilly



Investigating fair data acquisition for risk prediction in resource-constrained settings

Ioanna Thoma, Matthew Sperrin, Karla Diaz Ordaz, Ricardo Silva, Brieuc Lehmann



A critical benchmark of Bayesian shrinkage estimation for subgroup analysis

Sebastian Weber, Björn Bornkamp, David Ohlssen



Mathematical Modelling of Oxygenation Dynamics Using High-Resolution Perfusion Data: An Advanced Statistical Framework for Understanding Oxygen Metabolism

Mansour Taghavi Azar Sharabiani, Alireza Mahani, Richard Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica



Marginal structural Cox model with weighted cumulative exposure modelling for the estimation of counterfactual Population Attributable Fractions

Yue Zhai, Ana-Maria Vilcu, Jacques Benichou, Lucas Morin, Agnès Fournier, Anne Thiébaut, Vivian Viallon



Lost in the Forest of Forest Plots? Practical Guidelines and an All-in-One Tool for Forest Plots

Hongqiu Gu, Yong Jiang, Hao Li



Robust Outlier Detection with Skewness-Adjusted Fences: Theoretical Foundations and Applications

YUNCHAE JUNG, MINSU PARK



Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles in Linear Regression: An Application to Estimating Shelf Life

Lingjiao Wang, Yang Han, Wei Liu, Frank Bretz



One-sided simultaneous tolerance intervals based on kernel density estimates

Gian Louisse Roy



Robust large-scale multiple testing for hidden Markov random field model

Donghwan Lee, Jiyn Sun



Model informed assurance approach for 3-way PK similarity studies

Rachid El Galta, Roland Baumgartner



Korea Sequence Read Archive (KRA) - A public repository for archiving raw sequence data

JAEHO LEE



Integrative analysis of transcriptomic and epigenomic dynamics of liver organoids using single cell RNA-seq and ATAC-seq

Kwang Hoon Cho, Jong-Hwan Kim, Jimin Kim, Jahyun Yun, Dayeon Kang



Leveraging tumor imaging compositional data structure in model feature space for predicting recurrence in colorectal carcinoma

Olivia J Bobek, Nicholas Larson, Rish K Pai, Fang-Shu Ou



BayesPIM: A Bayesian Prevalence-Incidence Mixture Model for Screening Outcomes, with an Application to Colorectal Cancer

Thomas Klausch, Birgit Lissenberg-Witte, Veerle Coupé



Joint Modelling of Random Heterogeneity in Longitudinal and Multiple time-to-Events in Colon Cancer

DIVYA DENNIS, Jagathnath Krishna KM



Refining the Association between BMI, Waist Circumference, and Breast Cancer Risk in Postmenopausal Women using G-formula Method

Somin Jeon, Boyoung Park, Junghyun Yoon



Building cancer risk prediction models by synthesizing national registry and prevention trial data

Oksana Chernova, Donna Ankerst, Ruth M Pfeiffer



Modelling Individual-level Uncertainty from Missing Data in Personalised Breast Cancer Risk Prediction

Bethan L. White, Lorenzo Ficorella, Xin Yang, Douglas F. Easton, Antonis C. Antoniou



Time-varying covariates in Survival Analysis: a graphical approach to assessing the risk of cardiovascular events and aortic valve sclerosis development

Arianna Galotta, Francesco Maria Mattio, Veronika Myasoedova, Elisabetta Salvioni, Paolo Poggio, Piergiuseppe Agostoni, Alice Bonomi



Polygenic scores as tools for intervention selection in the setting of finasteride for prostate cancer prevention

Allison Meisner



Implementation of a Disease Progression Model accounting for covariates

Gabrielle Casimiro, Sofia Kaisaridi, Sophie Tezenas du Montcel



Genetics influences LDL-C response to statin therapy: short- and long-term observational study with functional data analysis

Andrea Corbetta, Emanuele Di Angelantonio, Andrea Ganna, Francesca Ieva



Longitudinal analysis of imprecise disease status using latent Markov models: application to Italian Thyroid Cancer Observatory data

Silvia D'Elia, Marco Alfò, Maria Francesca Marino



Long-term risk prediction from short-term data – a microsimulation approach

Moritz Pamminger, Theresa Ullmann, Moritz Madern, Daniela Dunkler, Georg Heinze



Deep learning algorithm for dynamic survival prediction with competitive risks

Tristan Margaté, Marine Zulian, Agathe Guilloux, Sandrine Katsahian



Identifying Cutoff in Predictors in Survival Analysis: An Ensemble Strategy for Flexible Knot Selection

Stefania Lando, Giulia Lorenzoni, Dario Gregori



Estimating Quality Adjusted Life Years (QALYs) from a joint modeling framework: a simulation-based study

Vincent Bonnemains, Yohann Foucher, Philippe Tessier, Etienne Dantan



An Alternative Estimand for Overall Survival in the Presence of Treatment Discontinuation: Simulation Results and Case Study

Kara-Louise Royle, David Meads, Jennifer Visser-Rogers, David A Cairns, Ian R White



Corrections of confidence interval for differences in restricted mean survival times in clinical trials with small sample sizes

Hiroya Hashimoto, Akiko Kada



Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry

Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson



Development and validation of prognostic models in phase I oncology clinical trials

Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr



Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint

Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva



Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors

Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux



Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration

Luca Genetti, Andrea Nizzardo, Marco Pergher



Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials

XINGZHI XU, SATOSHI HATTORI



Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints

Go Horiguchi, Isao Yokota, Satoshi Teramukai



Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes

Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap



Estimands in platform trials with time - treatment interactions

ZIYAN WANG, Dave Woods



A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design

Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess



Optimizing Biomarker-Based Enrichment strategies in clinical trials

Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun



Leveraging Synthetic Data for Enhanced Clinical Research Outcomes

Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska



Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL

Byoung Ha Yoon



Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM

Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk



Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models

ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI



Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand

Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian



Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol

Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme



Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards.

Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson



Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models

Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott



Automating Report Generation with Stata: A Case Study of NORUSE

Maria Elstad



Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis.

MOHAMMED ABDU MUDAWI



Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis

Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner



Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes

Mahru Ahmad, Jack Wilkinson, Andy Vail



Causal discovery for multi-cohort studies

Christine Bang, Vanessa Didelez



Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms

A F M Tahsin Shahriar, AHM Mahbub-ul Latif



Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods

Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao



Revisiting subgroup analysis: A reflection on health disparities using conditional independence

Nia Kang, Tibor Schuster



Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study

Jingya Zhao, Gareth Ambler, Baptiste Leurent



Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods.

Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden



Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome

Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz



Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis

Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka



Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative

Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier



Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol

Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango



Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates

Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume



Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial.

Robin Young, Alex McConnachie, Helen Minnis



The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation

Gregory Chen, Micahel Seo, Isaac Gravestock



Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials

Patrick Djidel, Armand Chouzy, Pierre Colin



Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance

Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock



Power calculation using the win-ratio for composite outcomes in randomized trials

David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held



Feasibility of propensity score weighted analysis in rare disease trials: a simulation study

Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini



A basket trial for rare diseases, with a crossover design for its substudies: a simulation study

Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout



Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias

Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets



Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials

Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng



Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials

Anjali Yadav

11:30am
-
1:00pm
Poster Exhibition: T / Tuesday posters
Location: Poster Location
 

Leveraging Wearable data for Probabilistic Imputation in Cardiovascular Risk Calculators.

Antoine Faul, Patric Wyss, Anja Mühlemann, Manuela Moraru, Danielle Bower, Petra Stute, Ben Spycher, David Ginsbourger



Stepwise Prediction of Tuberculosis Treatment Outcomes Using XGBoost and Feature-Level Analysis: A Multi-Stage Approach to Clinical Decision Support

Linfeng Wang, Jody Phelan, Taane Clark



The use of variable selection in clinical prediction modelling for binary outcomes: a systematic review

Xinrui Su, Gareth Ambler, Nathan Green, Menelaos Pavlou



Comparison of Methods for Incorporating Related Data when Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen Martin, David Jenkins



A Systematic Review of Methodological Research on Multi-State Prediction Models

Chantelle Cornett, Glen Martin, Alexander Pate, Victoria Palin



Assessing the robustness of prediction models: A case study on in-hospital mortality prediction using MIMIC-III and MIMIC-IV

Alan Balendran, Raphaël Porcher



The Influence of Variable Selection Approaches on Prediction Model Stability in Low-Dimensional Data: From Traditional Stepwise Selection to Regularisation techniques

Noraworn Jirattikanwong, Phichayut Phinyo, Pakpoom Wongyikul, Natthanaphop Isaradech, Wachiranun Sirikul, Wuttipat Kiratipaisarl



Early-detection of high-risk patient profiles admitted to hospital with respiratory infections using a multistate model

João Pedro Carmezim, Cristian Tebé, Natàlia Pallarès, Roger Paredes, Cavan Reilly



Investigating fair data acquisition for risk prediction in resource-constrained settings

Ioanna Thoma, Matthew Sperrin, Karla Diaz Ordaz, Ricardo Silva, Brieuc Lehmann



A critical benchmark of Bayesian shrinkage estimation for subgroup analysis

Sebastian Weber, Björn Bornkamp, David Ohlssen



Mathematical Modelling of Oxygenation Dynamics Using High-Resolution Perfusion Data: An Advanced Statistical Framework for Understanding Oxygen Metabolism

Mansour Taghavi Azar Sharabiani, Alireza Mahani, Richard Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica



Marginal structural Cox model with weighted cumulative exposure modelling for the estimation of counterfactual Population Attributable Fractions

Yue Zhai, Ana-Maria Vilcu, Jacques Benichou, Lucas Morin, Agnès Fournier, Anne Thiébaut, Vivian Viallon



Lost in the Forest of Forest Plots? Practical Guidelines and an All-in-One Tool for Forest Plots

Hongqiu Gu, Yong Jiang, Hao Li



Robust Outlier Detection with Skewness-Adjusted Fences: Theoretical Foundations and Applications

YUNCHAE JUNG, MINSU PARK



Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles in Linear Regression: An Application to Estimating Shelf Life

Lingjiao Wang, Yang Han, Wei Liu, Frank Bretz



One-sided simultaneous tolerance intervals based on kernel density estimates

Gian Louisse Roy



Robust large-scale multiple testing for hidden Markov random field model

Donghwan Lee, Jiyn Sun



Model informed assurance approach for 3-way PK similarity studies

Rachid El Galta, Roland Baumgartner



Korea Sequence Read Archive (KRA) - A public repository for archiving raw sequence data

JAEHO LEE



Integrative analysis of transcriptomic and epigenomic dynamics of liver organoids using single cell RNA-seq and ATAC-seq

Kwang Hoon Cho, Jong-Hwan Kim, Jimin Kim, Jahyun Yun, Dayeon Kang



Leveraging tumor imaging compositional data structure in model feature space for predicting recurrence in colorectal carcinoma

Olivia J Bobek, Nicholas Larson, Rish K Pai, Fang-Shu Ou



BayesPIM: A Bayesian Prevalence-Incidence Mixture Model for Screening Outcomes, with an Application to Colorectal Cancer

Thomas Klausch, Birgit Lissenberg-Witte, Veerle Coupé



Joint Modelling of Random Heterogeneity in Longitudinal and Multiple time-to-Events in Colon Cancer

DIVYA DENNIS, Jagathnath Krishna KM



Refining the Association between BMI, Waist Circumference, and Breast Cancer Risk in Postmenopausal Women using G-formula Method

Somin Jeon, Boyoung Park, Junghyun Yoon



Building cancer risk prediction models by synthesizing national registry and prevention trial data

Oksana Chernova, Donna Ankerst, Ruth M Pfeiffer



Modelling Individual-level Uncertainty from Missing Data in Personalised Breast Cancer Risk Prediction

Bethan L. White, Lorenzo Ficorella, Xin Yang, Douglas F. Easton, Antonis C. Antoniou



Time-varying covariates in Survival Analysis: a graphical approach to assessing the risk of cardiovascular events and aortic valve sclerosis development

Arianna Galotta, Francesco Maria Mattio, Veronika Myasoedova, Elisabetta Salvioni, Paolo Poggio, Piergiuseppe Agostoni, Alice Bonomi



Polygenic scores as tools for intervention selection in the setting of finasteride for prostate cancer prevention

Allison Meisner



Implementation of a Disease Progression Model accounting for covariates

Gabrielle Casimiro, Sofia Kaisaridi, Sophie Tezenas du Montcel



Genetics influences LDL-C response to statin therapy: short- and long-term observational study with functional data analysis

Andrea Corbetta, Emanuele Di Angelantonio, Andrea Ganna, Francesca Ieva



Longitudinal analysis of imprecise disease status using latent Markov models: application to Italian Thyroid Cancer Observatory data

Silvia D'Elia, Marco Alfò, Maria Francesca Marino



Long-term risk prediction from short-term data – a microsimulation approach

Moritz Pamminger, Theresa Ullmann, Moritz Madern, Daniela Dunkler, Georg Heinze



Deep learning algorithm for dynamic survival prediction with competitive risks

Tristan Margaté, Marine Zulian, Agathe Guilloux, Sandrine Katsahian



Identifying Cutoff in Predictors in Survival Analysis: An Ensemble Strategy for Flexible Knot Selection

Stefania Lando, Giulia Lorenzoni, Dario Gregori



Estimating Quality Adjusted Life Years (QALYs) from a joint modeling framework: a simulation-based study

Vincent Bonnemains, Yohann Foucher, Philippe Tessier, Etienne Dantan



An Alternative Estimand for Overall Survival in the Presence of Treatment Discontinuation: Simulation Results and Case Study

Kara-Louise Royle, David Meads, Jennifer Visser-Rogers, David A Cairns, Ian R White



Corrections of confidence interval for differences in restricted mean survival times in clinical trials with small sample sizes

Hiroya Hashimoto, Akiko Kada



Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry

Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson



Development and validation of prognostic models in phase I oncology clinical trials

Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr



Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint

Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva



Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors

Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux



Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration

Luca Genetti, Andrea Nizzardo, Marco Pergher



Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials

XINGZHI XU, SATOSHI HATTORI



Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints

Go Horiguchi, Isao Yokota, Satoshi Teramukai



Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes

Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap



Estimands in platform trials with time - treatment interactions

ZIYAN WANG, Dave Woods



A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design

Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess



Optimizing Biomarker-Based Enrichment strategies in clinical trials

Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun



Leveraging Synthetic Data for Enhanced Clinical Research Outcomes

Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska



Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL

Byoung Ha Yoon



Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM

Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk



Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models

ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI



Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand

Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian



Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol

Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme



Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards.

Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson



Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models

Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott



Automating Report Generation with Stata: A Case Study of NORUSE

Maria Elstad



Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis.

MOHAMMED ABDU MUDAWI



Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis

Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner



Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes

Mahru Ahmad, Jack Wilkinson, Andy Vail



Causal discovery for multi-cohort studies

Christine Bang, Vanessa Didelez



Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms

A F M Tahsin Shahriar, AHM Mahbub-ul Latif



Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods

Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao



Revisiting subgroup analysis: A reflection on health disparities using conditional independence

Nia Kang, Tibor Schuster



Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study

Jingya Zhao, Gareth Ambler, Baptiste Leurent



Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods.

Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden



Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome

Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz



Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis

Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka



Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative

Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier



Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol

Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango



Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates

Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume



Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial.

Robin Young, Alex McConnachie, Helen Minnis



The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation

Gregory Chen, Micahel Seo, Isaac Gravestock



Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials

Patrick Djidel, Armand Chouzy, Pierre Colin



Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance

Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock



Power calculation using the win-ratio for composite outcomes in randomized trials

David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held



Feasibility of propensity score weighted analysis in rare disease trials: a simulation study

Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini



A basket trial for rare diseases, with a crossover design for its substudies: a simulation study

Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout



Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias

Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets



Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials

Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng



Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials

Anjali Yadav

1:00pm
-
2:00pm
Poster Exhibition: T / Tuesday posters
Location: Poster Location
 

Leveraging Wearable data for Probabilistic Imputation in Cardiovascular Risk Calculators.

Antoine Faul, Patric Wyss, Anja Mühlemann, Manuela Moraru, Danielle Bower, Petra Stute, Ben Spycher, David Ginsbourger



Stepwise Prediction of Tuberculosis Treatment Outcomes Using XGBoost and Feature-Level Analysis: A Multi-Stage Approach to Clinical Decision Support

Linfeng Wang, Jody Phelan, Taane Clark



The use of variable selection in clinical prediction modelling for binary outcomes: a systematic review

Xinrui Su, Gareth Ambler, Nathan Green, Menelaos Pavlou



Comparison of Methods for Incorporating Related Data when Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen Martin, David Jenkins



A Systematic Review of Methodological Research on Multi-State Prediction Models

Chantelle Cornett, Glen Martin, Alexander Pate, Victoria Palin



Assessing the robustness of prediction models: A case study on in-hospital mortality prediction using MIMIC-III and MIMIC-IV

Alan Balendran, Raphaël Porcher



The Influence of Variable Selection Approaches on Prediction Model Stability in Low-Dimensional Data: From Traditional Stepwise Selection to Regularisation techniques

Noraworn Jirattikanwong, Phichayut Phinyo, Pakpoom Wongyikul, Natthanaphop Isaradech, Wachiranun Sirikul, Wuttipat Kiratipaisarl



Early-detection of high-risk patient profiles admitted to hospital with respiratory infections using a multistate model

João Pedro Carmezim, Cristian Tebé, Natàlia Pallarès, Roger Paredes, Cavan Reilly



Investigating fair data acquisition for risk prediction in resource-constrained settings

Ioanna Thoma, Matthew Sperrin, Karla Diaz Ordaz, Ricardo Silva, Brieuc Lehmann



A critical benchmark of Bayesian shrinkage estimation for subgroup analysis

Sebastian Weber, Björn Bornkamp, David Ohlssen



Mathematical Modelling of Oxygenation Dynamics Using High-Resolution Perfusion Data: An Advanced Statistical Framework for Understanding Oxygen Metabolism

Mansour Taghavi Azar Sharabiani, Alireza Mahani, Richard Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica



Marginal structural Cox model with weighted cumulative exposure modelling for the estimation of counterfactual Population Attributable Fractions

Yue Zhai, Ana-Maria Vilcu, Jacques Benichou, Lucas Morin, Agnès Fournier, Anne Thiébaut, Vivian Viallon



Lost in the Forest of Forest Plots? Practical Guidelines and an All-in-One Tool for Forest Plots

Hongqiu Gu, Yong Jiang, Hao Li



Robust Outlier Detection with Skewness-Adjusted Fences: Theoretical Foundations and Applications

YUNCHAE JUNG, MINSU PARK



Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles in Linear Regression: An Application to Estimating Shelf Life

Lingjiao Wang, Yang Han, Wei Liu, Frank Bretz



One-sided simultaneous tolerance intervals based on kernel density estimates

Gian Louisse Roy



Robust large-scale multiple testing for hidden Markov random field model

Donghwan Lee, Jiyn Sun



Model informed assurance approach for 3-way PK similarity studies

Rachid El Galta, Roland Baumgartner



Korea Sequence Read Archive (KRA) - A public repository for archiving raw sequence data

JAEHO LEE



Integrative analysis of transcriptomic and epigenomic dynamics of liver organoids using single cell RNA-seq and ATAC-seq

Kwang Hoon Cho, Jong-Hwan Kim, Jimin Kim, Jahyun Yun, Dayeon Kang



Leveraging tumor imaging compositional data structure in model feature space for predicting recurrence in colorectal carcinoma

Olivia J Bobek, Nicholas Larson, Rish K Pai, Fang-Shu Ou



BayesPIM: A Bayesian Prevalence-Incidence Mixture Model for Screening Outcomes, with an Application to Colorectal Cancer

Thomas Klausch, Birgit Lissenberg-Witte, Veerle Coupé



Joint Modelling of Random Heterogeneity in Longitudinal and Multiple time-to-Events in Colon Cancer

DIVYA DENNIS, Jagathnath Krishna KM



Refining the Association between BMI, Waist Circumference, and Breast Cancer Risk in Postmenopausal Women using G-formula Method

Somin Jeon, Boyoung Park, Junghyun Yoon



Building cancer risk prediction models by synthesizing national registry and prevention trial data

Oksana Chernova, Donna Ankerst, Ruth M Pfeiffer



Modelling Individual-level Uncertainty from Missing Data in Personalised Breast Cancer Risk Prediction

Bethan L. White, Lorenzo Ficorella, Xin Yang, Douglas F. Easton, Antonis C. Antoniou



Time-varying covariates in Survival Analysis: a graphical approach to assessing the risk of cardiovascular events and aortic valve sclerosis development

Arianna Galotta, Francesco Maria Mattio, Veronika Myasoedova, Elisabetta Salvioni, Paolo Poggio, Piergiuseppe Agostoni, Alice Bonomi



Polygenic scores as tools for intervention selection in the setting of finasteride for prostate cancer prevention

Allison Meisner



Implementation of a Disease Progression Model accounting for covariates

Gabrielle Casimiro, Sofia Kaisaridi, Sophie Tezenas du Montcel



Genetics influences LDL-C response to statin therapy: short- and long-term observational study with functional data analysis

Andrea Corbetta, Emanuele Di Angelantonio, Andrea Ganna, Francesca Ieva



Longitudinal analysis of imprecise disease status using latent Markov models: application to Italian Thyroid Cancer Observatory data

Silvia D'Elia, Marco Alfò, Maria Francesca Marino



Long-term risk prediction from short-term data – a microsimulation approach

Moritz Pamminger, Theresa Ullmann, Moritz Madern, Daniela Dunkler, Georg Heinze



Deep learning algorithm for dynamic survival prediction with competitive risks

Tristan Margaté, Marine Zulian, Agathe Guilloux, Sandrine Katsahian



Identifying Cutoff in Predictors in Survival Analysis: An Ensemble Strategy for Flexible Knot Selection

Stefania Lando, Giulia Lorenzoni, Dario Gregori



Estimating Quality Adjusted Life Years (QALYs) from a joint modeling framework: a simulation-based study

Vincent Bonnemains, Yohann Foucher, Philippe Tessier, Etienne Dantan



An Alternative Estimand for Overall Survival in the Presence of Treatment Discontinuation: Simulation Results and Case Study

Kara-Louise Royle, David Meads, Jennifer Visser-Rogers, David A Cairns, Ian R White



Corrections of confidence interval for differences in restricted mean survival times in clinical trials with small sample sizes

Hiroya Hashimoto, Akiko Kada



Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry

Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson



Development and validation of prognostic models in phase I oncology clinical trials

Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr



Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint

Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva



Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors

Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux



Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration

Luca Genetti, Andrea Nizzardo, Marco Pergher



Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials

XINGZHI XU, SATOSHI HATTORI



Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints

Go Horiguchi, Isao Yokota, Satoshi Teramukai



Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes

Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap



Estimands in platform trials with time - treatment interactions

ZIYAN WANG, Dave Woods



A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design

Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess



Optimizing Biomarker-Based Enrichment strategies in clinical trials

Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun



Leveraging Synthetic Data for Enhanced Clinical Research Outcomes

Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska



Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL

Byoung Ha Yoon



Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM

Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk



Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models

ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI



Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand

Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian



Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol

Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme



Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards.

Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson



Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models

Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott



Automating Report Generation with Stata: A Case Study of NORUSE

Maria Elstad



Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis.

MOHAMMED ABDU MUDAWI



Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis

Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner



Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes

Mahru Ahmad, Jack Wilkinson, Andy Vail



Causal discovery for multi-cohort studies

Christine Bang, Vanessa Didelez



Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms

A F M Tahsin Shahriar, AHM Mahbub-ul Latif



Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods

Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao



Revisiting subgroup analysis: A reflection on health disparities using conditional independence

Nia Kang, Tibor Schuster



Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study

Jingya Zhao, Gareth Ambler, Baptiste Leurent



Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods.

Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden



Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome

Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz



Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis

Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka



Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative

Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier



Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol

Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango



Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates

Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume



Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial.

Robin Young, Alex McConnachie, Helen Minnis



The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation

Gregory Chen, Micahel Seo, Isaac Gravestock



Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials

Patrick Djidel, Armand Chouzy, Pierre Colin



Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance

Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock



Power calculation using the win-ratio for composite outcomes in randomized trials

David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held



Feasibility of propensity score weighted analysis in rare disease trials: a simulation study

Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini



A basket trial for rare diseases, with a crossover design for its substudies: a simulation study

Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout



Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias

Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets



Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials

Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng



Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials

Anjali Yadav

Date: Wednesday, 27/Aug/2025
9:00am
-
10:30am
Poster Exhibition: W / Wednesday posters
Location: Poster Location
 

Exploring the Exposome correlated with Body Mass Index in Adolescents: Findings from the 2014-2015 and 2022-2023 KNHANES

Hye Ah Lee, Hyesook Park



Flexible statistical modeling of undernutrition among under-five children in India

SHAMBHAVI MISHRA



Comparison of deep learning models with different architectures and training populations for ECG age estimation: Accuracy, agreement, and CVD prediction

Arya Panthalanickal Vijayakumar, Tom Wilsgaard, Henrik Schirmer, Ernest Diez Benavente, René van Es, Rutger R. van de Leur, Haakon Lindekleiv, Zachi I. Attia, Francisco Lopez-Jimenez, David A. Leon, Olena Iakunchykova



Systematic review and real life-oriented evaluation on methods for feature selection in longitudinal biomedical data

Alexander Gieswinkel, Gregor Buch, Gökhan Gül, Vincent ten Cate, Lisa Hartung, Philipp S. Wild



How does acute exposure to environmental factors relate to stroke characteristics such as stroke type, severity, and impairments?

BOHAN ZHANG, Andy Vail, Craig Smith, Amit Kishore, Matthew Gittins



Improving TBI Prognosis in developing world: A Machine Learning-based AutoScore Approach to Predict Six-Month Functional Outcome

Vineet Kumar Kamal, Deepak Agrawal



Predictive Risk Index for Poor Cognitive Development Among Children Using Machine Learning Approaches

Anita Kerubo Ogero, Patricia Kipkemoi, Amina Abubakar



Development and validation of a model to predict ceiling of care in COVID-19 hospitalised patients

Natàlia Pallarès Fontanet, Hristo Inouzhe, Jordi Cortés, Sam Straw, Klaus K Witte, Jordi Carratalà, Sebastià Videla, Cristian Tebé



Transformer Models for Clinical Prediction – Investigation of BEHRT in UK Biobank and prediction assessment under different scenarios

Yusuf Yildiz, Goran Nenadic, Meghna Jani, David A. Jenkins



What is the best way to analyse ventilator-free days?

Laurent Renard Triché, Matthieu Jabaudon, Bruno Pereira, Sylvie Chevret



Compare Estimation and Classification Performances of Statistical Shrinkage Methods Ridge Regression, Lasso Regression, and Elastic Net Regression

Gamze Ozen, Fezan Mutlu



Defining Harm in Settings with Outcomes that are Not Binary

Amit Sawant, Mats Stensrud



Brier pseudo-observation score for selecting a multiplicative, an additive or an additive-multiplicative hazards regression model

François Lefebvre, Roch Giorgi



Bayesian spatio-temporal analysis of the COVID-19 pandemic in Catalonia

Pau Satorra, Cristian Tebé



A Simulation Study of Bayesian Approaches to Spatial Modelling Using the Besag-York-Mollie Model

Hollie Hughes, David Hughes



A Bayesian analysis of FINEARTS-HF

Alasdair D Henderson, Brian L Claggett, Akshay S Desai, Mutthiah Vaduganathan, Carolyn S Lam, Bertram Pitt, Michele Senni, Sanjiv J Shah, Adriaan A Voors, Faiez Zannad, Meike Brinker, Flaviana Amarante, Katja Rohwedder, James Lay-Flurrie, Scott D Solomon, John JV McMurray, Pardeep S Jhund



Fast Approximation of Joint Models: A Comparative Evaluation of Bayesian Methods

Jinghao Li, David M Hughes



Confidence Intervals for Comparing Two Independent Folded Normals

Eleonora Di Carluccio, Sarah Ogutu, Ozkan Köse, Henry G. Mwambi, Andreas Ziegler



Towards Realistic Synthetic Nanopore Protein Signals: A Comparative Study of Stochastic and GAN-Based Methods

Göran Köber, Jonas Bürgel, Tobias Ensslen, Oliver Amft



Data Transformations in Machine Learning Approaches for Studying Microbiota as a Biomarker of Non-Response Risk to CFTR Modulators

Marta Avalos, Céline Hosteins, Diego Kauer, Chloé Renault, Raphaël Enaud, Laurence Delhaes



On microbiome data analysis using Bayesian method under the assumption of a zero-inflated model

Yuki Ando, Asanao Shimokawa



Estimating prevalence of cystic fibrosis heterozygosity using Fast Boltzmann Inversion (FBI): An improved Monte Carlo algorithm for Bayesian inference

Jan Brink Valentin



A Sparse Graph Representation of Hi-C Data for Colorectal Cancer Prediction

Jiwon Im, Mingyu Go, Insu Jang, Minsu Park



A multi-state survival model for recurring adenomas in Lynch syndrome individuals

Vanessa García López-Mingo, Veerle Coupé, Marjolein Greuter, Thomas Klausch



Evaluating Completeness of Data in CPRD’s Breast Cancer Data: Implications for External Controls for Surrogate Endpoints

Dorcas N Kareithi, Jingky Lozano-Kuehne, David Sinclair, James Wason



Identification of risk factors for the development of de novo malignancies after liver transplantation

Tereza Hakova, Pavel Taimr, Tomáš Hucl, Zdeněk Valenta



Are ACE inhibitors associated with increased lung cancer risk, or are unmeasured confounders biasing results?

Sean Maguire, Ruth Keogh, Elizabeth Williamson, John Tazare



DO GENETIC CHANGES IN 15Q13.3 MEAN LOWER IQ SCORE?

Tadas Žvirblis, Pilar Caro, Audronė Jakaitienė, Christian Schaaf



Measuring the performance of survival models to personalize treatment choices

Orestis Efthimiou, Jeroen Hoogland, Thomas Debray, Valerie Aponte Ribero, Wilma Knol, Huiberdina Koek, Matthias Schwenkglenks, Séverine Henrard, Matthias Egger, Nicolas Rodondi, Ian White



A framework for estimating quality adjusted life years using joint models of longitudinal and survival data

Michael Crowther, Alessandro Gasparini, Sara Ekberg, Federico Felizzi, Elaine Gallagher, Noman Paracha



Cut Off Determination using Model Derived Estimate in Survival Prediction Model

Jungbok Lee



A two-step testing approach for comparing time-to-event data under non-proportional hazards

Jonas Brugger, Tim Friede, Florian Klinglmüller, Martin Posch, Franz König



A systematic review of Bayesian survival modelling for extrapolating survival in cost-effectiveness analysis

Farah Erdogan, Gwénaël Le Teuff



Power comparison of hazard ratio versus restricted mean survival time in the presence of cure

Ronald Bertus Geskus



Sample Size Calculation in Prognostic Studies: A Comparative Analysis

Gloria Brigiari, Ester Rosa, Giulia Lorenzoni, Dario Gregori



Prognostic Score Adjustment in a Two-Slope Mixed Effects Model to Estimate Treatment Effects on eGFR Slope in CKD Patients

Silke Janitza, Maike Ahrens, Sebastian Voss, Bohdana Ratitch, Nicole Rethemeier, Meike Brinker, Paula Vesterinen, Antigoni Elefsinioti



Comparative effectiveness of ACE inhibitors and angiotensin receptor blockers to prevent or delay dementia: a target trial emulation

Marie-Laure Charpignon, Max Sunog, Colin Magdamo, Bella Vakulenko-Lagun, Ioanna Tzoulaki, Sudeshna Das, Deborah Blacker, Mark Albers



Optimal utility-based design of phase II/phase III programmes with different type of endpoints in the setting of multiple myeloma

Haotian Wang, Peter Kimani, Michael Grayling, Josephine Khan, Nigel Stallard



Beyond first events: Advancing recurrent adverse event estimates in clinical research.

Nicolas Sauvageot, Leen Slaets, Anirban Mitra, Zoe Craig, Jane Gilbert, Lilla Di Scala, Stefan Englert



Cure models to compare aftercare monitoring schemes in pediatric cancer

Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck



Comparison of treatment sequences in advanced pancreatic cancer

Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke



Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions

Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti



A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses

Martin Kappler, Yuan Ji



Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies

Vibha Srichand



Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials

Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar



Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study

Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan



Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies

Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida



Navigating complex and computationally demanding clinical trial simulation

Saumil Shah, Mitchell Thomann



Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms

Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera



Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making

Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder



Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations

Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder



Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis

Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT



Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY

Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo



Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care

Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori



Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana

Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe



Application of machine learning methods for the analysis of randomised controlled trials: A systematic review

Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani



Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates

Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka



Mediation analysis for exploring gender differences in mortality among acute myocardial infarction

Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi



Bivariate random-effects models for the meta-analysis of rare events

Danyu Li, Patrick Taffe



Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators

Yasuyuki Okuda, Masataka Taguri



Causal framework for analyzing mediation effects of clinical biomarkers

Jinesh Shah



A Modified Doubly Robust Estimator for Clustered Causal Inference: Integrating GLMM and GBM

Samina Naznin, Dr. Mohaimen Monsur



DoubleMLDeep: Estimation of Causal Effects with Multimodal Data

Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar



Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials

Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel



Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials

Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier



Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study

Nerissa Nance, Romain Neugebauer



Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio

Junxian Zhu, Mark Y. Chan, Bee-Choo Tai



Blinded sample size recalculation for randomized controlled trials with analysis of covariance

Takumi Kanata, Yasuhiro Hagiwara, Koji Oba



Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies

Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi



Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study

Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis



Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes

Shashank Tripathi, Rachna Agarwal



Optimal standardization as an alternative to matching using propensity scores

Ekkehard Glimm, Lillian Yau



Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias

Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones



Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review

Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan



WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations

Autumn O Donnell



Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials

Lillian Yau, Betty Molloy



Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach

Satomi OKAMURA, Eisuke HIDA



Adding baskets to an ongoing basket trial with information borrowing: When do you benefit?

Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki



Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions

Valeria Mazzanti, Dirk Klingbiel



N-of-1 Trials to Estimate Individual Effects of Music on Concentration

Thomas Gärtner, Fabian Stolp, Stefan Konigorski



Simulation Study Examining Impact of Study Design Factors on Variability Measures

Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch



Simulation-based optimization of adaptive designs using a generalized version of assurance

Pantelis Vlachos, Valeria Mazzanti, Boaz Adler



Evaluating the impact of outcome delay on adaptive designs

Aritra Mukherjee, Michael J. Grayling, James M. S. Wason

10:30am
-
11:00am
Poster Exhibition: W / Wednesday posters
Location: Poster Location
 

Exploring the Exposome correlated with Body Mass Index in Adolescents: Findings from the 2014-2015 and 2022-2023 KNHANES

Hye Ah Lee, Hyesook Park



Flexible statistical modeling of undernutrition among under-five children in India

SHAMBHAVI MISHRA



Comparison of deep learning models with different architectures and training populations for ECG age estimation: Accuracy, agreement, and CVD prediction

Arya Panthalanickal Vijayakumar, Tom Wilsgaard, Henrik Schirmer, Ernest Diez Benavente, René van Es, Rutger R. van de Leur, Haakon Lindekleiv, Zachi I. Attia, Francisco Lopez-Jimenez, David A. Leon, Olena Iakunchykova



Systematic review and real life-oriented evaluation on methods for feature selection in longitudinal biomedical data

Alexander Gieswinkel, Gregor Buch, Gökhan Gül, Vincent ten Cate, Lisa Hartung, Philipp S. Wild



How does acute exposure to environmental factors relate to stroke characteristics such as stroke type, severity, and impairments?

BOHAN ZHANG, Andy Vail, Craig Smith, Amit Kishore, Matthew Gittins



Improving TBI Prognosis in developing world: A Machine Learning-based AutoScore Approach to Predict Six-Month Functional Outcome

Vineet Kumar Kamal, Deepak Agrawal



Predictive Risk Index for Poor Cognitive Development Among Children Using Machine Learning Approaches

Anita Kerubo Ogero, Patricia Kipkemoi, Amina Abubakar



Development and validation of a model to predict ceiling of care in COVID-19 hospitalised patients

Natàlia Pallarès Fontanet, Hristo Inouzhe, Jordi Cortés, Sam Straw, Klaus K Witte, Jordi Carratalà, Sebastià Videla, Cristian Tebé



Transformer Models for Clinical Prediction – Investigation of BEHRT in UK Biobank and prediction assessment under different scenarios

Yusuf Yildiz, Goran Nenadic, Meghna Jani, David A. Jenkins



What is the best way to analyse ventilator-free days?

Laurent Renard Triché, Matthieu Jabaudon, Bruno Pereira, Sylvie Chevret



Compare Estimation and Classification Performances of Statistical Shrinkage Methods Ridge Regression, Lasso Regression, and Elastic Net Regression

Gamze Ozen, Fezan Mutlu



Defining Harm in Settings with Outcomes that are Not Binary

Amit Sawant, Mats Stensrud



Brier pseudo-observation score for selecting a multiplicative, an additive or an additive-multiplicative hazards regression model

François Lefebvre, Roch Giorgi



Bayesian spatio-temporal analysis of the COVID-19 pandemic in Catalonia

Pau Satorra, Cristian Tebé



A Simulation Study of Bayesian Approaches to Spatial Modelling Using the Besag-York-Mollie Model

Hollie Hughes, David Hughes



A Bayesian analysis of FINEARTS-HF

Alasdair D Henderson, Brian L Claggett, Akshay S Desai, Mutthiah Vaduganathan, Carolyn S Lam, Bertram Pitt, Michele Senni, Sanjiv J Shah, Adriaan A Voors, Faiez Zannad, Meike Brinker, Flaviana Amarante, Katja Rohwedder, James Lay-Flurrie, Scott D Solomon, John JV McMurray, Pardeep S Jhund



Fast Approximation of Joint Models: A Comparative Evaluation of Bayesian Methods

Jinghao Li, David M Hughes



Confidence Intervals for Comparing Two Independent Folded Normals

Eleonora Di Carluccio, Sarah Ogutu, Ozkan Köse, Henry G. Mwambi, Andreas Ziegler



Towards Realistic Synthetic Nanopore Protein Signals: A Comparative Study of Stochastic and GAN-Based Methods

Göran Köber, Jonas Bürgel, Tobias Ensslen, Oliver Amft



Data Transformations in Machine Learning Approaches for Studying Microbiota as a Biomarker of Non-Response Risk to CFTR Modulators

Marta Avalos, Céline Hosteins, Diego Kauer, Chloé Renault, Raphaël Enaud, Laurence Delhaes



On microbiome data analysis using Bayesian method under the assumption of a zero-inflated model

Yuki Ando, Asanao Shimokawa



Estimating prevalence of cystic fibrosis heterozygosity using Fast Boltzmann Inversion (FBI): An improved Monte Carlo algorithm for Bayesian inference

Jan Brink Valentin



A Sparse Graph Representation of Hi-C Data for Colorectal Cancer Prediction

Jiwon Im, Mingyu Go, Insu Jang, Minsu Park



A multi-state survival model for recurring adenomas in Lynch syndrome individuals

Vanessa García López-Mingo, Veerle Coupé, Marjolein Greuter, Thomas Klausch



Evaluating Completeness of Data in CPRD’s Breast Cancer Data: Implications for External Controls for Surrogate Endpoints

Dorcas N Kareithi, Jingky Lozano-Kuehne, David Sinclair, James Wason



Identification of risk factors for the development of de novo malignancies after liver transplantation

Tereza Hakova, Pavel Taimr, Tomáš Hucl, Zdeněk Valenta



Are ACE inhibitors associated with increased lung cancer risk, or are unmeasured confounders biasing results?

Sean Maguire, Ruth Keogh, Elizabeth Williamson, John Tazare



DO GENETIC CHANGES IN 15Q13.3 MEAN LOWER IQ SCORE?

Tadas Žvirblis, Pilar Caro, Audronė Jakaitienė, Christian Schaaf



Measuring the performance of survival models to personalize treatment choices

Orestis Efthimiou, Jeroen Hoogland, Thomas Debray, Valerie Aponte Ribero, Wilma Knol, Huiberdina Koek, Matthias Schwenkglenks, Séverine Henrard, Matthias Egger, Nicolas Rodondi, Ian White



A framework for estimating quality adjusted life years using joint models of longitudinal and survival data

Michael Crowther, Alessandro Gasparini, Sara Ekberg, Federico Felizzi, Elaine Gallagher, Noman Paracha



Cut Off Determination using Model Derived Estimate in Survival Prediction Model

Jungbok Lee



A two-step testing approach for comparing time-to-event data under non-proportional hazards

Jonas Brugger, Tim Friede, Florian Klinglmüller, Martin Posch, Franz König



A systematic review of Bayesian survival modelling for extrapolating survival in cost-effectiveness analysis

Farah Erdogan, Gwénaël Le Teuff



Power comparison of hazard ratio versus restricted mean survival time in the presence of cure

Ronald Bertus Geskus



Sample Size Calculation in Prognostic Studies: A Comparative Analysis

Gloria Brigiari, Ester Rosa, Giulia Lorenzoni, Dario Gregori



Prognostic Score Adjustment in a Two-Slope Mixed Effects Model to Estimate Treatment Effects on eGFR Slope in CKD Patients

Silke Janitza, Maike Ahrens, Sebastian Voss, Bohdana Ratitch, Nicole Rethemeier, Meike Brinker, Paula Vesterinen, Antigoni Elefsinioti



Comparative effectiveness of ACE inhibitors and angiotensin receptor blockers to prevent or delay dementia: a target trial emulation

Marie-Laure Charpignon, Max Sunog, Colin Magdamo, Bella Vakulenko-Lagun, Ioanna Tzoulaki, Sudeshna Das, Deborah Blacker, Mark Albers



Optimal utility-based design of phase II/phase III programmes with different type of endpoints in the setting of multiple myeloma

Haotian Wang, Peter Kimani, Michael Grayling, Josephine Khan, Nigel Stallard



Beyond first events: Advancing recurrent adverse event estimates in clinical research.

Nicolas Sauvageot, Leen Slaets, Anirban Mitra, Zoe Craig, Jane Gilbert, Lilla Di Scala, Stefan Englert



Cure models to compare aftercare monitoring schemes in pediatric cancer

Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck



Comparison of treatment sequences in advanced pancreatic cancer

Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke



Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions

Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti



A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses

Martin Kappler, Yuan Ji



Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies

Vibha Srichand



Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials

Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar



Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study

Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan



Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies

Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida



Navigating complex and computationally demanding clinical trial simulation

Saumil Shah, Mitchell Thomann



Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms

Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera



Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making

Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder



Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations

Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder



Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis

Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT



Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY

Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo



Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care

Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori



Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana

Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe



Application of machine learning methods for the analysis of randomised controlled trials: A systematic review

Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani



Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates

Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka



Mediation analysis for exploring gender differences in mortality among acute myocardial infarction

Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi



Bivariate random-effects models for the meta-analysis of rare events

Danyu Li, Patrick Taffe



Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators

Yasuyuki Okuda, Masataka Taguri



Causal framework for analyzing mediation effects of clinical biomarkers

Jinesh Shah



A Modified Doubly Robust Estimator for Clustered Causal Inference: Integrating GLMM and GBM

Samina Naznin, Dr. Mohaimen Monsur



DoubleMLDeep: Estimation of Causal Effects with Multimodal Data

Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar



Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials

Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel



Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials

Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier



Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study

Nerissa Nance, Romain Neugebauer



Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio

Junxian Zhu, Mark Y. Chan, Bee-Choo Tai



Blinded sample size recalculation for randomized controlled trials with analysis of covariance

Takumi Kanata, Yasuhiro Hagiwara, Koji Oba



Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies

Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi



Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study

Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis



Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes

Shashank Tripathi, Rachna Agarwal



Optimal standardization as an alternative to matching using propensity scores

Ekkehard Glimm, Lillian Yau



Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias

Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones



Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review

Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan



WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations

Autumn O Donnell



Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials

Lillian Yau, Betty Molloy



Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach

Satomi OKAMURA, Eisuke HIDA



Adding baskets to an ongoing basket trial with information borrowing: When do you benefit?

Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki



Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions

Valeria Mazzanti, Dirk Klingbiel



N-of-1 Trials to Estimate Individual Effects of Music on Concentration

Thomas Gärtner, Fabian Stolp, Stefan Konigorski



Simulation Study Examining Impact of Study Design Factors on Variability Measures

Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch



Simulation-based optimization of adaptive designs using a generalized version of assurance

Pantelis Vlachos, Valeria Mazzanti, Boaz Adler



Evaluating the impact of outcome delay on adaptive designs

Aritra Mukherjee, Michael J. Grayling, James M. S. Wason

12:15pm
-
1:30pm
Poster Exhibition: W / Wednesday posters
Location: Poster Location
 

Exploring the Exposome correlated with Body Mass Index in Adolescents: Findings from the 2014-2015 and 2022-2023 KNHANES

Hye Ah Lee, Hyesook Park



Flexible statistical modeling of undernutrition among under-five children in India

SHAMBHAVI MISHRA



Comparison of deep learning models with different architectures and training populations for ECG age estimation: Accuracy, agreement, and CVD prediction

Arya Panthalanickal Vijayakumar, Tom Wilsgaard, Henrik Schirmer, Ernest Diez Benavente, René van Es, Rutger R. van de Leur, Haakon Lindekleiv, Zachi I. Attia, Francisco Lopez-Jimenez, David A. Leon, Olena Iakunchykova



Systematic review and real life-oriented evaluation on methods for feature selection in longitudinal biomedical data

Alexander Gieswinkel, Gregor Buch, Gökhan Gül, Vincent ten Cate, Lisa Hartung, Philipp S. Wild



How does acute exposure to environmental factors relate to stroke characteristics such as stroke type, severity, and impairments?

BOHAN ZHANG, Andy Vail, Craig Smith, Amit Kishore, Matthew Gittins



Improving TBI Prognosis in developing world: A Machine Learning-based AutoScore Approach to Predict Six-Month Functional Outcome

Vineet Kumar Kamal, Deepak Agrawal



Predictive Risk Index for Poor Cognitive Development Among Children Using Machine Learning Approaches

Anita Kerubo Ogero, Patricia Kipkemoi, Amina Abubakar



Development and validation of a model to predict ceiling of care in COVID-19 hospitalised patients

Natàlia Pallarès Fontanet, Hristo Inouzhe, Jordi Cortés, Sam Straw, Klaus K Witte, Jordi Carratalà, Sebastià Videla, Cristian Tebé



Transformer Models for Clinical Prediction – Investigation of BEHRT in UK Biobank and prediction assessment under different scenarios

Yusuf Yildiz, Goran Nenadic, Meghna Jani, David A. Jenkins



What is the best way to analyse ventilator-free days?

Laurent Renard Triché, Matthieu Jabaudon, Bruno Pereira, Sylvie Chevret



Compare Estimation and Classification Performances of Statistical Shrinkage Methods Ridge Regression, Lasso Regression, and Elastic Net Regression

Gamze Ozen, Fezan Mutlu



Defining Harm in Settings with Outcomes that are Not Binary

Amit Sawant, Mats Stensrud



Brier pseudo-observation score for selecting a multiplicative, an additive or an additive-multiplicative hazards regression model

François Lefebvre, Roch Giorgi



Bayesian spatio-temporal analysis of the COVID-19 pandemic in Catalonia

Pau Satorra, Cristian Tebé



A Simulation Study of Bayesian Approaches to Spatial Modelling Using the Besag-York-Mollie Model

Hollie Hughes, David Hughes



A Bayesian analysis of FINEARTS-HF

Alasdair D Henderson, Brian L Claggett, Akshay S Desai, Mutthiah Vaduganathan, Carolyn S Lam, Bertram Pitt, Michele Senni, Sanjiv J Shah, Adriaan A Voors, Faiez Zannad, Meike Brinker, Flaviana Amarante, Katja Rohwedder, James Lay-Flurrie, Scott D Solomon, John JV McMurray, Pardeep S Jhund



Fast Approximation of Joint Models: A Comparative Evaluation of Bayesian Methods

Jinghao Li, David M Hughes



Confidence Intervals for Comparing Two Independent Folded Normals

Eleonora Di Carluccio, Sarah Ogutu, Ozkan Köse, Henry G. Mwambi, Andreas Ziegler



Towards Realistic Synthetic Nanopore Protein Signals: A Comparative Study of Stochastic and GAN-Based Methods

Göran Köber, Jonas Bürgel, Tobias Ensslen, Oliver Amft



Data Transformations in Machine Learning Approaches for Studying Microbiota as a Biomarker of Non-Response Risk to CFTR Modulators

Marta Avalos, Céline Hosteins, Diego Kauer, Chloé Renault, Raphaël Enaud, Laurence Delhaes



On microbiome data analysis using Bayesian method under the assumption of a zero-inflated model

Yuki Ando, Asanao Shimokawa



Estimating prevalence of cystic fibrosis heterozygosity using Fast Boltzmann Inversion (FBI): An improved Monte Carlo algorithm for Bayesian inference

Jan Brink Valentin



A Sparse Graph Representation of Hi-C Data for Colorectal Cancer Prediction

Jiwon Im, Mingyu Go, Insu Jang, Minsu Park



A multi-state survival model for recurring adenomas in Lynch syndrome individuals

Vanessa García López-Mingo, Veerle Coupé, Marjolein Greuter, Thomas Klausch



Evaluating Completeness of Data in CPRD’s Breast Cancer Data: Implications for External Controls for Surrogate Endpoints

Dorcas N Kareithi, Jingky Lozano-Kuehne, David Sinclair, James Wason



Identification of risk factors for the development of de novo malignancies after liver transplantation

Tereza Hakova, Pavel Taimr, Tomáš Hucl, Zdeněk Valenta



Are ACE inhibitors associated with increased lung cancer risk, or are unmeasured confounders biasing results?

Sean Maguire, Ruth Keogh, Elizabeth Williamson, John Tazare



DO GENETIC CHANGES IN 15Q13.3 MEAN LOWER IQ SCORE?

Tadas Žvirblis, Pilar Caro, Audronė Jakaitienė, Christian Schaaf



Measuring the performance of survival models to personalize treatment choices

Orestis Efthimiou, Jeroen Hoogland, Thomas Debray, Valerie Aponte Ribero, Wilma Knol, Huiberdina Koek, Matthias Schwenkglenks, Séverine Henrard, Matthias Egger, Nicolas Rodondi, Ian White



A framework for estimating quality adjusted life years using joint models of longitudinal and survival data

Michael Crowther, Alessandro Gasparini, Sara Ekberg, Federico Felizzi, Elaine Gallagher, Noman Paracha



Cut Off Determination using Model Derived Estimate in Survival Prediction Model

Jungbok Lee



A two-step testing approach for comparing time-to-event data under non-proportional hazards

Jonas Brugger, Tim Friede, Florian Klinglmüller, Martin Posch, Franz König



A systematic review of Bayesian survival modelling for extrapolating survival in cost-effectiveness analysis

Farah Erdogan, Gwénaël Le Teuff



Power comparison of hazard ratio versus restricted mean survival time in the presence of cure

Ronald Bertus Geskus



Sample Size Calculation in Prognostic Studies: A Comparative Analysis

Gloria Brigiari, Ester Rosa, Giulia Lorenzoni, Dario Gregori



Prognostic Score Adjustment in a Two-Slope Mixed Effects Model to Estimate Treatment Effects on eGFR Slope in CKD Patients

Silke Janitza, Maike Ahrens, Sebastian Voss, Bohdana Ratitch, Nicole Rethemeier, Meike Brinker, Paula Vesterinen, Antigoni Elefsinioti



Comparative effectiveness of ACE inhibitors and angiotensin receptor blockers to prevent or delay dementia: a target trial emulation

Marie-Laure Charpignon, Max Sunog, Colin Magdamo, Bella Vakulenko-Lagun, Ioanna Tzoulaki, Sudeshna Das, Deborah Blacker, Mark Albers



Optimal utility-based design of phase II/phase III programmes with different type of endpoints in the setting of multiple myeloma

Haotian Wang, Peter Kimani, Michael Grayling, Josephine Khan, Nigel Stallard



Beyond first events: Advancing recurrent adverse event estimates in clinical research.

Nicolas Sauvageot, Leen Slaets, Anirban Mitra, Zoe Craig, Jane Gilbert, Lilla Di Scala, Stefan Englert



Cure models to compare aftercare monitoring schemes in pediatric cancer

Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck



Comparison of treatment sequences in advanced pancreatic cancer

Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke



Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions

Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti



A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses

Martin Kappler, Yuan Ji



Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies

Vibha Srichand



Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials

Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar



Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study

Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan



Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies

Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida



Navigating complex and computationally demanding clinical trial simulation

Saumil Shah, Mitchell Thomann



Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms

Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera



Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making

Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder



Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations

Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder



Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis

Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT



Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY

Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo



Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care

Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori



Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana

Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe



Application of machine learning methods for the analysis of randomised controlled trials: A systematic review

Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani



Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates

Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka



Mediation analysis for exploring gender differences in mortality among acute myocardial infarction

Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi



Bivariate random-effects models for the meta-analysis of rare events

Danyu Li, Patrick Taffe



Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators

Yasuyuki Okuda, Masataka Taguri



Causal framework for analyzing mediation effects of clinical biomarkers

Jinesh Shah



A Modified Doubly Robust Estimator for Clustered Causal Inference: Integrating GLMM and GBM

Samina Naznin, Dr. Mohaimen Monsur



DoubleMLDeep: Estimation of Causal Effects with Multimodal Data

Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar



Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials

Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel



Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials

Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier



Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study

Nerissa Nance, Romain Neugebauer



Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio

Junxian Zhu, Mark Y. Chan, Bee-Choo Tai



Blinded sample size recalculation for randomized controlled trials with analysis of covariance

Takumi Kanata, Yasuhiro Hagiwara, Koji Oba



Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies

Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi



Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study

Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis



Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes

Shashank Tripathi, Rachna Agarwal



Optimal standardization as an alternative to matching using propensity scores

Ekkehard Glimm, Lillian Yau



Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias

Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones



Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review

Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan



WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations

Autumn O Donnell



Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials

Lillian Yau, Betty Molloy



Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach

Satomi OKAMURA, Eisuke HIDA



Adding baskets to an ongoing basket trial with information borrowing: When do you benefit?

Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki



Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions

Valeria Mazzanti, Dirk Klingbiel



N-of-1 Trials to Estimate Individual Effects of Music on Concentration

Thomas Gärtner, Fabian Stolp, Stefan Konigorski



Simulation Study Examining Impact of Study Design Factors on Variability Measures

Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch



Simulation-based optimization of adaptive designs using a generalized version of assurance

Pantelis Vlachos, Valeria Mazzanti, Boaz Adler



Evaluating the impact of outcome delay on adaptive designs

Aritra Mukherjee, Michael J. Grayling, James M. S. Wason

1:00pm
-
2:00pm
Poster Exhibition: W / Wednesday posters
Location: Poster Location
 

Exploring the Exposome correlated with Body Mass Index in Adolescents: Findings from the 2014-2015 and 2022-2023 KNHANES

Hye Ah Lee, Hyesook Park



Flexible statistical modeling of undernutrition among under-five children in India

SHAMBHAVI MISHRA



Comparison of deep learning models with different architectures and training populations for ECG age estimation: Accuracy, agreement, and CVD prediction

Arya Panthalanickal Vijayakumar, Tom Wilsgaard, Henrik Schirmer, Ernest Diez Benavente, René van Es, Rutger R. van de Leur, Haakon Lindekleiv, Zachi I. Attia, Francisco Lopez-Jimenez, David A. Leon, Olena Iakunchykova



Systematic review and real life-oriented evaluation on methods for feature selection in longitudinal biomedical data

Alexander Gieswinkel, Gregor Buch, Gökhan Gül, Vincent ten Cate, Lisa Hartung, Philipp S. Wild



How does acute exposure to environmental factors relate to stroke characteristics such as stroke type, severity, and impairments?

BOHAN ZHANG, Andy Vail, Craig Smith, Amit Kishore, Matthew Gittins



Improving TBI Prognosis in developing world: A Machine Learning-based AutoScore Approach to Predict Six-Month Functional Outcome

Vineet Kumar Kamal, Deepak Agrawal



Predictive Risk Index for Poor Cognitive Development Among Children Using Machine Learning Approaches

Anita Kerubo Ogero, Patricia Kipkemoi, Amina Abubakar



Development and validation of a model to predict ceiling of care in COVID-19 hospitalised patients

Natàlia Pallarès Fontanet, Hristo Inouzhe, Jordi Cortés, Sam Straw, Klaus K Witte, Jordi Carratalà, Sebastià Videla, Cristian Tebé



Transformer Models for Clinical Prediction – Investigation of BEHRT in UK Biobank and prediction assessment under different scenarios

Yusuf Yildiz, Goran Nenadic, Meghna Jani, David A. Jenkins



What is the best way to analyse ventilator-free days?

Laurent Renard Triché, Matthieu Jabaudon, Bruno Pereira, Sylvie Chevret



Compare Estimation and Classification Performances of Statistical Shrinkage Methods Ridge Regression, Lasso Regression, and Elastic Net Regression

Gamze Ozen, Fezan Mutlu



Defining Harm in Settings with Outcomes that are Not Binary

Amit Sawant, Mats Stensrud



Brier pseudo-observation score for selecting a multiplicative, an additive or an additive-multiplicative hazards regression model

François Lefebvre, Roch Giorgi



Bayesian spatio-temporal analysis of the COVID-19 pandemic in Catalonia

Pau Satorra, Cristian Tebé



A Simulation Study of Bayesian Approaches to Spatial Modelling Using the Besag-York-Mollie Model

Hollie Hughes, David Hughes



A Bayesian analysis of FINEARTS-HF

Alasdair D Henderson, Brian L Claggett, Akshay S Desai, Mutthiah Vaduganathan, Carolyn S Lam, Bertram Pitt, Michele Senni, Sanjiv J Shah, Adriaan A Voors, Faiez Zannad, Meike Brinker, Flaviana Amarante, Katja Rohwedder, James Lay-Flurrie, Scott D Solomon, John JV McMurray, Pardeep S Jhund



Fast Approximation of Joint Models: A Comparative Evaluation of Bayesian Methods

Jinghao Li, David M Hughes



Confidence Intervals for Comparing Two Independent Folded Normals

Eleonora Di Carluccio, Sarah Ogutu, Ozkan Köse, Henry G. Mwambi, Andreas Ziegler



Towards Realistic Synthetic Nanopore Protein Signals: A Comparative Study of Stochastic and GAN-Based Methods

Göran Köber, Jonas Bürgel, Tobias Ensslen, Oliver Amft



Data Transformations in Machine Learning Approaches for Studying Microbiota as a Biomarker of Non-Response Risk to CFTR Modulators

Marta Avalos, Céline Hosteins, Diego Kauer, Chloé Renault, Raphaël Enaud, Laurence Delhaes



On microbiome data analysis using Bayesian method under the assumption of a zero-inflated model

Yuki Ando, Asanao Shimokawa



Estimating prevalence of cystic fibrosis heterozygosity using Fast Boltzmann Inversion (FBI): An improved Monte Carlo algorithm for Bayesian inference

Jan Brink Valentin



A Sparse Graph Representation of Hi-C Data for Colorectal Cancer Prediction

Jiwon Im, Mingyu Go, Insu Jang, Minsu Park



A multi-state survival model for recurring adenomas in Lynch syndrome individuals

Vanessa García López-Mingo, Veerle Coupé, Marjolein Greuter, Thomas Klausch



Evaluating Completeness of Data in CPRD’s Breast Cancer Data: Implications for External Controls for Surrogate Endpoints

Dorcas N Kareithi, Jingky Lozano-Kuehne, David Sinclair, James Wason



Identification of risk factors for the development of de novo malignancies after liver transplantation

Tereza Hakova, Pavel Taimr, Tomáš Hucl, Zdeněk Valenta



Are ACE inhibitors associated with increased lung cancer risk, or are unmeasured confounders biasing results?

Sean Maguire, Ruth Keogh, Elizabeth Williamson, John Tazare



DO GENETIC CHANGES IN 15Q13.3 MEAN LOWER IQ SCORE?

Tadas Žvirblis, Pilar Caro, Audronė Jakaitienė, Christian Schaaf



Measuring the performance of survival models to personalize treatment choices

Orestis Efthimiou, Jeroen Hoogland, Thomas Debray, Valerie Aponte Ribero, Wilma Knol, Huiberdina Koek, Matthias Schwenkglenks, Séverine Henrard, Matthias Egger, Nicolas Rodondi, Ian White



A framework for estimating quality adjusted life years using joint models of longitudinal and survival data

Michael Crowther, Alessandro Gasparini, Sara Ekberg, Federico Felizzi, Elaine Gallagher, Noman Paracha



Cut Off Determination using Model Derived Estimate in Survival Prediction Model

Jungbok Lee



A two-step testing approach for comparing time-to-event data under non-proportional hazards

Jonas Brugger, Tim Friede, Florian Klinglmüller, Martin Posch, Franz König



A systematic review of Bayesian survival modelling for extrapolating survival in cost-effectiveness analysis

Farah Erdogan, Gwénaël Le Teuff



Power comparison of hazard ratio versus restricted mean survival time in the presence of cure

Ronald Bertus Geskus



Sample Size Calculation in Prognostic Studies: A Comparative Analysis

Gloria Brigiari, Ester Rosa, Giulia Lorenzoni, Dario Gregori



Prognostic Score Adjustment in a Two-Slope Mixed Effects Model to Estimate Treatment Effects on eGFR Slope in CKD Patients

Silke Janitza, Maike Ahrens, Sebastian Voss, Bohdana Ratitch, Nicole Rethemeier, Meike Brinker, Paula Vesterinen, Antigoni Elefsinioti



Comparative effectiveness of ACE inhibitors and angiotensin receptor blockers to prevent or delay dementia: a target trial emulation

Marie-Laure Charpignon, Max Sunog, Colin Magdamo, Bella Vakulenko-Lagun, Ioanna Tzoulaki, Sudeshna Das, Deborah Blacker, Mark Albers



Optimal utility-based design of phase II/phase III programmes with different type of endpoints in the setting of multiple myeloma

Haotian Wang, Peter Kimani, Michael Grayling, Josephine Khan, Nigel Stallard



Beyond first events: Advancing recurrent adverse event estimates in clinical research.

Nicolas Sauvageot, Leen Slaets, Anirban Mitra, Zoe Craig, Jane Gilbert, Lilla Di Scala, Stefan Englert



Cure models to compare aftercare monitoring schemes in pediatric cancer

Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck



Comparison of treatment sequences in advanced pancreatic cancer

Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke



Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions

Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti



A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses

Martin Kappler, Yuan Ji



Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies

Vibha Srichand



Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials

Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar



Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study

Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan



Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies

Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida



Navigating complex and computationally demanding clinical trial simulation

Saumil Shah, Mitchell Thomann



Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms

Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera



Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making

Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder



Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations

Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder



Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis

Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT



Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY

Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo



Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care

Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori



Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana

Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe



Application of machine learning methods for the analysis of randomised controlled trials: A systematic review

Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani



Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates

Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka



Mediation analysis for exploring gender differences in mortality among acute myocardial infarction

Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi



Bivariate random-effects models for the meta-analysis of rare events

Danyu Li, Patrick Taffe



Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators

Yasuyuki Okuda, Masataka Taguri



Causal framework for analyzing mediation effects of clinical biomarkers

Jinesh Shah



A Modified Doubly Robust Estimator for Clustered Causal Inference: Integrating GLMM and GBM

Samina Naznin, Dr. Mohaimen Monsur



DoubleMLDeep: Estimation of Causal Effects with Multimodal Data

Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar



Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials

Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel



Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials

Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier



Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study

Nerissa Nance, Romain Neugebauer



Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio

Junxian Zhu, Mark Y. Chan, Bee-Choo Tai



Blinded sample size recalculation for randomized controlled trials with analysis of covariance

Takumi Kanata, Yasuhiro Hagiwara, Koji Oba



Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies

Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi



Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study

Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis



Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes

Shashank Tripathi, Rachna Agarwal



Optimal standardization as an alternative to matching using propensity scores

Ekkehard Glimm, Lillian Yau



Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias

Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones



Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review

Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan



WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations

Autumn O Donnell



Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials

Lillian Yau, Betty Molloy



Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach

Satomi OKAMURA, Eisuke HIDA



Adding baskets to an ongoing basket trial with information borrowing: When do you benefit?

Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki



Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions

Valeria Mazzanti, Dirk Klingbiel



N-of-1 Trials to Estimate Individual Effects of Music on Concentration

Thomas Gärtner, Fabian Stolp, Stefan Konigorski



Simulation Study Examining Impact of Study Design Factors on Variability Measures

Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch



Simulation-based optimization of adaptive designs using a generalized version of assurance

Pantelis Vlachos, Valeria Mazzanti, Boaz Adler



Evaluating the impact of outcome delay on adaptive designs

Aritra Mukherjee, Michael J. Grayling, James M. S. Wason

2:00pm
-
3:30pm
Poster Exhibition: W / Wednesday posters
Location: Poster Location
 

Exploring the Exposome correlated with Body Mass Index in Adolescents: Findings from the 2014-2015 and 2022-2023 KNHANES

Hye Ah Lee, Hyesook Park



Flexible statistical modeling of undernutrition among under-five children in India

SHAMBHAVI MISHRA



Comparison of deep learning models with different architectures and training populations for ECG age estimation: Accuracy, agreement, and CVD prediction

Arya Panthalanickal Vijayakumar, Tom Wilsgaard, Henrik Schirmer, Ernest Diez Benavente, René van Es, Rutger R. van de Leur, Haakon Lindekleiv, Zachi I. Attia, Francisco Lopez-Jimenez, David A. Leon, Olena Iakunchykova



Systematic review and real life-oriented evaluation on methods for feature selection in longitudinal biomedical data

Alexander Gieswinkel, Gregor Buch, Gökhan Gül, Vincent ten Cate, Lisa Hartung, Philipp S. Wild



How does acute exposure to environmental factors relate to stroke characteristics such as stroke type, severity, and impairments?

BOHAN ZHANG, Andy Vail, Craig Smith, Amit Kishore, Matthew Gittins



Improving TBI Prognosis in developing world: A Machine Learning-based AutoScore Approach to Predict Six-Month Functional Outcome

Vineet Kumar Kamal, Deepak Agrawal



Predictive Risk Index for Poor Cognitive Development Among Children Using Machine Learning Approaches

Anita Kerubo Ogero, Patricia Kipkemoi, Amina Abubakar



Development and validation of a model to predict ceiling of care in COVID-19 hospitalised patients

Natàlia Pallarès Fontanet, Hristo Inouzhe, Jordi Cortés, Sam Straw, Klaus K Witte, Jordi Carratalà, Sebastià Videla, Cristian Tebé



Transformer Models for Clinical Prediction – Investigation of BEHRT in UK Biobank and prediction assessment under different scenarios

Yusuf Yildiz, Goran Nenadic, Meghna Jani, David A. Jenkins



What is the best way to analyse ventilator-free days?

Laurent Renard Triché, Matthieu Jabaudon, Bruno Pereira, Sylvie Chevret



Compare Estimation and Classification Performances of Statistical Shrinkage Methods Ridge Regression, Lasso Regression, and Elastic Net Regression

Gamze Ozen, Fezan Mutlu



Defining Harm in Settings with Outcomes that are Not Binary

Amit Sawant, Mats Stensrud



Brier pseudo-observation score for selecting a multiplicative, an additive or an additive-multiplicative hazards regression model

François Lefebvre, Roch Giorgi



Bayesian spatio-temporal analysis of the COVID-19 pandemic in Catalonia

Pau Satorra, Cristian Tebé



A Simulation Study of Bayesian Approaches to Spatial Modelling Using the Besag-York-Mollie Model

Hollie Hughes, David Hughes



A Bayesian analysis of FINEARTS-HF

Alasdair D Henderson, Brian L Claggett, Akshay S Desai, Mutthiah Vaduganathan, Carolyn S Lam, Bertram Pitt, Michele Senni, Sanjiv J Shah, Adriaan A Voors, Faiez Zannad, Meike Brinker, Flaviana Amarante, Katja Rohwedder, James Lay-Flurrie, Scott D Solomon, John JV McMurray, Pardeep S Jhund



Fast Approximation of Joint Models: A Comparative Evaluation of Bayesian Methods

Jinghao Li, David M Hughes



Confidence Intervals for Comparing Two Independent Folded Normals

Eleonora Di Carluccio, Sarah Ogutu, Ozkan Köse, Henry G. Mwambi, Andreas Ziegler



Towards Realistic Synthetic Nanopore Protein Signals: A Comparative Study of Stochastic and GAN-Based Methods

Göran Köber, Jonas Bürgel, Tobias Ensslen, Oliver Amft



Data Transformations in Machine Learning Approaches for Studying Microbiota as a Biomarker of Non-Response Risk to CFTR Modulators

Marta Avalos, Céline Hosteins, Diego Kauer, Chloé Renault, Raphaël Enaud, Laurence Delhaes



On microbiome data analysis using Bayesian method under the assumption of a zero-inflated model

Yuki Ando, Asanao Shimokawa



Estimating prevalence of cystic fibrosis heterozygosity using Fast Boltzmann Inversion (FBI): An improved Monte Carlo algorithm for Bayesian inference

Jan Brink Valentin



A Sparse Graph Representation of Hi-C Data for Colorectal Cancer Prediction

Jiwon Im, Mingyu Go, Insu Jang, Minsu Park



A multi-state survival model for recurring adenomas in Lynch syndrome individuals

Vanessa García López-Mingo, Veerle Coupé, Marjolein Greuter, Thomas Klausch



Evaluating Completeness of Data in CPRD’s Breast Cancer Data: Implications for External Controls for Surrogate Endpoints

Dorcas N Kareithi, Jingky Lozano-Kuehne, David Sinclair, James Wason



Identification of risk factors for the development of de novo malignancies after liver transplantation

Tereza Hakova, Pavel Taimr, Tomáš Hucl, Zdeněk Valenta



Are ACE inhibitors associated with increased lung cancer risk, or are unmeasured confounders biasing results?

Sean Maguire, Ruth Keogh, Elizabeth Williamson, John Tazare



DO GENETIC CHANGES IN 15Q13.3 MEAN LOWER IQ SCORE?

Tadas Žvirblis, Pilar Caro, Audronė Jakaitienė, Christian Schaaf



Measuring the performance of survival models to personalize treatment choices

Orestis Efthimiou, Jeroen Hoogland, Thomas Debray, Valerie Aponte Ribero, Wilma Knol, Huiberdina Koek, Matthias Schwenkglenks, Séverine Henrard, Matthias Egger, Nicolas Rodondi, Ian White



A framework for estimating quality adjusted life years using joint models of longitudinal and survival data

Michael Crowther, Alessandro Gasparini, Sara Ekberg, Federico Felizzi, Elaine Gallagher, Noman Paracha



Cut Off Determination using Model Derived Estimate in Survival Prediction Model

Jungbok Lee



A two-step testing approach for comparing time-to-event data under non-proportional hazards

Jonas Brugger, Tim Friede, Florian Klinglmüller, Martin Posch, Franz König



A systematic review of Bayesian survival modelling for extrapolating survival in cost-effectiveness analysis

Farah Erdogan, Gwénaël Le Teuff



Power comparison of hazard ratio versus restricted mean survival time in the presence of cure

Ronald Bertus Geskus



Sample Size Calculation in Prognostic Studies: A Comparative Analysis

Gloria Brigiari, Ester Rosa, Giulia Lorenzoni, Dario Gregori



Prognostic Score Adjustment in a Two-Slope Mixed Effects Model to Estimate Treatment Effects on eGFR Slope in CKD Patients

Silke Janitza, Maike Ahrens, Sebastian Voss, Bohdana Ratitch, Nicole Rethemeier, Meike Brinker, Paula Vesterinen, Antigoni Elefsinioti



Comparative effectiveness of ACE inhibitors and angiotensin receptor blockers to prevent or delay dementia: a target trial emulation

Marie-Laure Charpignon, Max Sunog, Colin Magdamo, Bella Vakulenko-Lagun, Ioanna Tzoulaki, Sudeshna Das, Deborah Blacker, Mark Albers



Optimal utility-based design of phase II/phase III programmes with different type of endpoints in the setting of multiple myeloma

Haotian Wang, Peter Kimani, Michael Grayling, Josephine Khan, Nigel Stallard



Beyond first events: Advancing recurrent adverse event estimates in clinical research.

Nicolas Sauvageot, Leen Slaets, Anirban Mitra, Zoe Craig, Jane Gilbert, Lilla Di Scala, Stefan Englert



Cure models to compare aftercare monitoring schemes in pediatric cancer

Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck



Comparison of treatment sequences in advanced pancreatic cancer

Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke



Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions

Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti



A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses

Martin Kappler, Yuan Ji



Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies

Vibha Srichand



Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials

Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar



Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study

Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan



Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies

Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida



Navigating complex and computationally demanding clinical trial simulation

Saumil Shah, Mitchell Thomann



Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms

Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera



Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making

Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder



Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations

Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder



Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis

Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT



Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY

Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo



Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care

Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori



Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana

Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe



Application of machine learning methods for the analysis of randomised controlled trials: A systematic review

Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani



Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates

Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka



Mediation analysis for exploring gender differences in mortality among acute myocardial infarction

Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi



Bivariate random-effects models for the meta-analysis of rare events

Danyu Li, Patrick Taffe



Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators

Yasuyuki Okuda, Masataka Taguri



Causal framework for analyzing mediation effects of clinical biomarkers

Jinesh Shah



A Modified Doubly Robust Estimator for Clustered Causal Inference: Integrating GLMM and GBM

Samina Naznin, Dr. Mohaimen Monsur



DoubleMLDeep: Estimation of Causal Effects with Multimodal Data

Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar



Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials

Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel



Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials

Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier



Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study

Nerissa Nance, Romain Neugebauer



Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio

Junxian Zhu, Mark Y. Chan, Bee-Choo Tai



Blinded sample size recalculation for randomized controlled trials with analysis of covariance

Takumi Kanata, Yasuhiro Hagiwara, Koji Oba



Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies

Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi



Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study

Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis



Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes

Shashank Tripathi, Rachna Agarwal



Optimal standardization as an alternative to matching using propensity scores

Ekkehard Glimm, Lillian Yau



Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias

Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones



Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review

Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan



WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations

Autumn O Donnell



Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials

Lillian Yau, Betty Molloy



Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach

Satomi OKAMURA, Eisuke HIDA



Adding baskets to an ongoing basket trial with information borrowing: When do you benefit?

Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki



Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions

Valeria Mazzanti, Dirk Klingbiel



N-of-1 Trials to Estimate Individual Effects of Music on Concentration

Thomas Gärtner, Fabian Stolp, Stefan Konigorski



Simulation Study Examining Impact of Study Design Factors on Variability Measures

Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch



Simulation-based optimization of adaptive designs using a generalized version of assurance

Pantelis Vlachos, Valeria Mazzanti, Boaz Adler



Evaluating the impact of outcome delay on adaptive designs

Aritra Mukherjee, Michael J. Grayling, James M. S. Wason

3:30pm
-
4:00pm
Poster Exhibition: W / Wednesday posters
Location: Poster Location
 

Exploring the Exposome correlated with Body Mass Index in Adolescents: Findings from the 2014-2015 and 2022-2023 KNHANES

Hye Ah Lee, Hyesook Park



Flexible statistical modeling of undernutrition among under-five children in India

SHAMBHAVI MISHRA



Comparison of deep learning models with different architectures and training populations for ECG age estimation: Accuracy, agreement, and CVD prediction

Arya Panthalanickal Vijayakumar, Tom Wilsgaard, Henrik Schirmer, Ernest Diez Benavente, René van Es, Rutger R. van de Leur, Haakon Lindekleiv, Zachi I. Attia, Francisco Lopez-Jimenez, David A. Leon, Olena Iakunchykova



Systematic review and real life-oriented evaluation on methods for feature selection in longitudinal biomedical data

Alexander Gieswinkel, Gregor Buch, Gökhan Gül, Vincent ten Cate, Lisa Hartung, Philipp S. Wild



How does acute exposure to environmental factors relate to stroke characteristics such as stroke type, severity, and impairments?

BOHAN ZHANG, Andy Vail, Craig Smith, Amit Kishore, Matthew Gittins



Improving TBI Prognosis in developing world: A Machine Learning-based AutoScore Approach to Predict Six-Month Functional Outcome

Vineet Kumar Kamal, Deepak Agrawal



Predictive Risk Index for Poor Cognitive Development Among Children Using Machine Learning Approaches

Anita Kerubo Ogero, Patricia Kipkemoi, Amina Abubakar



Development and validation of a model to predict ceiling of care in COVID-19 hospitalised patients

Natàlia Pallarès Fontanet, Hristo Inouzhe, Jordi Cortés, Sam Straw, Klaus K Witte, Jordi Carratalà, Sebastià Videla, Cristian Tebé



Transformer Models for Clinical Prediction – Investigation of BEHRT in UK Biobank and prediction assessment under different scenarios

Yusuf Yildiz, Goran Nenadic, Meghna Jani, David A. Jenkins



What is the best way to analyse ventilator-free days?

Laurent Renard Triché, Matthieu Jabaudon, Bruno Pereira, Sylvie Chevret



Compare Estimation and Classification Performances of Statistical Shrinkage Methods Ridge Regression, Lasso Regression, and Elastic Net Regression

Gamze Ozen, Fezan Mutlu



Defining Harm in Settings with Outcomes that are Not Binary

Amit Sawant, Mats Stensrud



Brier pseudo-observation score for selecting a multiplicative, an additive or an additive-multiplicative hazards regression model

François Lefebvre, Roch Giorgi



Bayesian spatio-temporal analysis of the COVID-19 pandemic in Catalonia

Pau Satorra, Cristian Tebé



A Simulation Study of Bayesian Approaches to Spatial Modelling Using the Besag-York-Mollie Model

Hollie Hughes, David Hughes



A Bayesian analysis of FINEARTS-HF

Alasdair D Henderson, Brian L Claggett, Akshay S Desai, Mutthiah Vaduganathan, Carolyn S Lam, Bertram Pitt, Michele Senni, Sanjiv J Shah, Adriaan A Voors, Faiez Zannad, Meike Brinker, Flaviana Amarante, Katja Rohwedder, James Lay-Flurrie, Scott D Solomon, John JV McMurray, Pardeep S Jhund



Fast Approximation of Joint Models: A Comparative Evaluation of Bayesian Methods

Jinghao Li, David M Hughes



Confidence Intervals for Comparing Two Independent Folded Normals

Eleonora Di Carluccio, Sarah Ogutu, Ozkan Köse, Henry G. Mwambi, Andreas Ziegler



Towards Realistic Synthetic Nanopore Protein Signals: A Comparative Study of Stochastic and GAN-Based Methods

Göran Köber, Jonas Bürgel, Tobias Ensslen, Oliver Amft



Data Transformations in Machine Learning Approaches for Studying Microbiota as a Biomarker of Non-Response Risk to CFTR Modulators

Marta Avalos, Céline Hosteins, Diego Kauer, Chloé Renault, Raphaël Enaud, Laurence Delhaes



On microbiome data analysis using Bayesian method under the assumption of a zero-inflated model

Yuki Ando, Asanao Shimokawa



Estimating prevalence of cystic fibrosis heterozygosity using Fast Boltzmann Inversion (FBI): An improved Monte Carlo algorithm for Bayesian inference

Jan Brink Valentin



A Sparse Graph Representation of Hi-C Data for Colorectal Cancer Prediction

Jiwon Im, Mingyu Go, Insu Jang, Minsu Park



A multi-state survival model for recurring adenomas in Lynch syndrome individuals

Vanessa García López-Mingo, Veerle Coupé, Marjolein Greuter, Thomas Klausch



Evaluating Completeness of Data in CPRD’s Breast Cancer Data: Implications for External Controls for Surrogate Endpoints

Dorcas N Kareithi, Jingky Lozano-Kuehne, David Sinclair, James Wason



Identification of risk factors for the development of de novo malignancies after liver transplantation

Tereza Hakova, Pavel Taimr, Tomáš Hucl, Zdeněk Valenta



Are ACE inhibitors associated with increased lung cancer risk, or are unmeasured confounders biasing results?

Sean Maguire, Ruth Keogh, Elizabeth Williamson, John Tazare



DO GENETIC CHANGES IN 15Q13.3 MEAN LOWER IQ SCORE?

Tadas Žvirblis, Pilar Caro, Audronė Jakaitienė, Christian Schaaf



Measuring the performance of survival models to personalize treatment choices

Orestis Efthimiou, Jeroen Hoogland, Thomas Debray, Valerie Aponte Ribero, Wilma Knol, Huiberdina Koek, Matthias Schwenkglenks, Séverine Henrard, Matthias Egger, Nicolas Rodondi, Ian White



A framework for estimating quality adjusted life years using joint models of longitudinal and survival data

Michael Crowther, Alessandro Gasparini, Sara Ekberg, Federico Felizzi, Elaine Gallagher, Noman Paracha



Cut Off Determination using Model Derived Estimate in Survival Prediction Model

Jungbok Lee



A two-step testing approach for comparing time-to-event data under non-proportional hazards

Jonas Brugger, Tim Friede, Florian Klinglmüller, Martin Posch, Franz König



A systematic review of Bayesian survival modelling for extrapolating survival in cost-effectiveness analysis

Farah Erdogan, Gwénaël Le Teuff



Power comparison of hazard ratio versus restricted mean survival time in the presence of cure

Ronald Bertus Geskus



Sample Size Calculation in Prognostic Studies: A Comparative Analysis

Gloria Brigiari, Ester Rosa, Giulia Lorenzoni, Dario Gregori



Prognostic Score Adjustment in a Two-Slope Mixed Effects Model to Estimate Treatment Effects on eGFR Slope in CKD Patients

Silke Janitza, Maike Ahrens, Sebastian Voss, Bohdana Ratitch, Nicole Rethemeier, Meike Brinker, Paula Vesterinen, Antigoni Elefsinioti



Comparative effectiveness of ACE inhibitors and angiotensin receptor blockers to prevent or delay dementia: a target trial emulation

Marie-Laure Charpignon, Max Sunog, Colin Magdamo, Bella Vakulenko-Lagun, Ioanna Tzoulaki, Sudeshna Das, Deborah Blacker, Mark Albers



Optimal utility-based design of phase II/phase III programmes with different type of endpoints in the setting of multiple myeloma

Haotian Wang, Peter Kimani, Michael Grayling, Josephine Khan, Nigel Stallard



Beyond first events: Advancing recurrent adverse event estimates in clinical research.

Nicolas Sauvageot, Leen Slaets, Anirban Mitra, Zoe Craig, Jane Gilbert, Lilla Di Scala, Stefan Englert



Cure models to compare aftercare monitoring schemes in pediatric cancer

Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck



Comparison of treatment sequences in advanced pancreatic cancer

Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke



Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions

Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti



A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses

Martin Kappler, Yuan Ji



Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies

Vibha Srichand



Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials

Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar



Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study

Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan



Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies

Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida



Navigating complex and computationally demanding clinical trial simulation

Saumil Shah, Mitchell Thomann



Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms

Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera



Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making

Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder



Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations

Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder



Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis

Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT



Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY

Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo



Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care

Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori



Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana

Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe



Application of machine learning methods for the analysis of randomised controlled trials: A systematic review

Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani



Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates

Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka



Mediation analysis for exploring gender differences in mortality among acute myocardial infarction

Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi



Bivariate random-effects models for the meta-analysis of rare events

Danyu Li, Patrick Taffe



Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators

Yasuyuki Okuda, Masataka Taguri



Causal framework for analyzing mediation effects of clinical biomarkers

Jinesh Shah



A Modified Doubly Robust Estimator for Clustered Causal Inference: Integrating GLMM and GBM

Samina Naznin, Dr. Mohaimen Monsur



DoubleMLDeep: Estimation of Causal Effects with Multimodal Data

Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar



Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials

Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel



Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials

Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier



Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study

Nerissa Nance, Romain Neugebauer



Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio

Junxian Zhu, Mark Y. Chan, Bee-Choo Tai



Blinded sample size recalculation for randomized controlled trials with analysis of covariance

Takumi Kanata, Yasuhiro Hagiwara, Koji Oba



Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies

Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi



Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study

Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis



Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes

Shashank Tripathi, Rachna Agarwal



Optimal standardization as an alternative to matching using propensity scores

Ekkehard Glimm, Lillian Yau



Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias

Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones



Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review

Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan



WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations

Autumn O Donnell



Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials

Lillian Yau, Betty Molloy



Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach

Satomi OKAMURA, Eisuke HIDA



Adding baskets to an ongoing basket trial with information borrowing: When do you benefit?

Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki



Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions

Valeria Mazzanti, Dirk Klingbiel



N-of-1 Trials to Estimate Individual Effects of Music on Concentration

Thomas Gärtner, Fabian Stolp, Stefan Konigorski



Simulation Study Examining Impact of Study Design Factors on Variability Measures

Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch



Simulation-based optimization of adaptive designs using a generalized version of assurance

Pantelis Vlachos, Valeria Mazzanti, Boaz Adler



Evaluating the impact of outcome delay on adaptive designs

Aritra Mukherjee, Michael J. Grayling, James M. S. Wason

4:00pm
-
5:30pm
Poster Exhibition: W / Wednesday posters
Location: Poster Location
 

Exploring the Exposome correlated with Body Mass Index in Adolescents: Findings from the 2014-2015 and 2022-2023 KNHANES

Hye Ah Lee, Hyesook Park



Flexible statistical modeling of undernutrition among under-five children in India

SHAMBHAVI MISHRA



Comparison of deep learning models with different architectures and training populations for ECG age estimation: Accuracy, agreement, and CVD prediction

Arya Panthalanickal Vijayakumar, Tom Wilsgaard, Henrik Schirmer, Ernest Diez Benavente, René van Es, Rutger R. van de Leur, Haakon Lindekleiv, Zachi I. Attia, Francisco Lopez-Jimenez, David A. Leon, Olena Iakunchykova



Systematic review and real life-oriented evaluation on methods for feature selection in longitudinal biomedical data

Alexander Gieswinkel, Gregor Buch, Gökhan Gül, Vincent ten Cate, Lisa Hartung, Philipp S. Wild



How does acute exposure to environmental factors relate to stroke characteristics such as stroke type, severity, and impairments?

BOHAN ZHANG, Andy Vail, Craig Smith, Amit Kishore, Matthew Gittins



Improving TBI Prognosis in developing world: A Machine Learning-based AutoScore Approach to Predict Six-Month Functional Outcome

Vineet Kumar Kamal, Deepak Agrawal



Predictive Risk Index for Poor Cognitive Development Among Children Using Machine Learning Approaches

Anita Kerubo Ogero, Patricia Kipkemoi, Amina Abubakar



Development and validation of a model to predict ceiling of care in COVID-19 hospitalised patients

Natàlia Pallarès Fontanet, Hristo Inouzhe, Jordi Cortés, Sam Straw, Klaus K Witte, Jordi Carratalà, Sebastià Videla, Cristian Tebé



Transformer Models for Clinical Prediction – Investigation of BEHRT in UK Biobank and prediction assessment under different scenarios

Yusuf Yildiz, Goran Nenadic, Meghna Jani, David A. Jenkins



What is the best way to analyse ventilator-free days?

Laurent Renard Triché, Matthieu Jabaudon, Bruno Pereira, Sylvie Chevret



Compare Estimation and Classification Performances of Statistical Shrinkage Methods Ridge Regression, Lasso Regression, and Elastic Net Regression

Gamze Ozen, Fezan Mutlu



Defining Harm in Settings with Outcomes that are Not Binary

Amit Sawant, Mats Stensrud



Brier pseudo-observation score for selecting a multiplicative, an additive or an additive-multiplicative hazards regression model

François Lefebvre, Roch Giorgi



Bayesian spatio-temporal analysis of the COVID-19 pandemic in Catalonia

Pau Satorra, Cristian Tebé



A Simulation Study of Bayesian Approaches to Spatial Modelling Using the Besag-York-Mollie Model

Hollie Hughes, David Hughes



A Bayesian analysis of FINEARTS-HF

Alasdair D Henderson, Brian L Claggett, Akshay S Desai, Mutthiah Vaduganathan, Carolyn S Lam, Bertram Pitt, Michele Senni, Sanjiv J Shah, Adriaan A Voors, Faiez Zannad, Meike Brinker, Flaviana Amarante, Katja Rohwedder, James Lay-Flurrie, Scott D Solomon, John JV McMurray, Pardeep S Jhund



Fast Approximation of Joint Models: A Comparative Evaluation of Bayesian Methods

Jinghao Li, David M Hughes



Confidence Intervals for Comparing Two Independent Folded Normals

Eleonora Di Carluccio, Sarah Ogutu, Ozkan Köse, Henry G. Mwambi, Andreas Ziegler



Towards Realistic Synthetic Nanopore Protein Signals: A Comparative Study of Stochastic and GAN-Based Methods

Göran Köber, Jonas Bürgel, Tobias Ensslen, Oliver Amft



Data Transformations in Machine Learning Approaches for Studying Microbiota as a Biomarker of Non-Response Risk to CFTR Modulators

Marta Avalos, Céline Hosteins, Diego Kauer, Chloé Renault, Raphaël Enaud, Laurence Delhaes



On microbiome data analysis using Bayesian method under the assumption of a zero-inflated model

Yuki Ando, Asanao Shimokawa



Estimating prevalence of cystic fibrosis heterozygosity using Fast Boltzmann Inversion (FBI): An improved Monte Carlo algorithm for Bayesian inference

Jan Brink Valentin



A Sparse Graph Representation of Hi-C Data for Colorectal Cancer Prediction

Jiwon Im, Mingyu Go, Insu Jang, Minsu Park



A multi-state survival model for recurring adenomas in Lynch syndrome individuals

Vanessa García López-Mingo, Veerle Coupé, Marjolein Greuter, Thomas Klausch



Evaluating Completeness of Data in CPRD’s Breast Cancer Data: Implications for External Controls for Surrogate Endpoints

Dorcas N Kareithi, Jingky Lozano-Kuehne, David Sinclair, James Wason



Identification of risk factors for the development of de novo malignancies after liver transplantation

Tereza Hakova, Pavel Taimr, Tomáš Hucl, Zdeněk Valenta



Are ACE inhibitors associated with increased lung cancer risk, or are unmeasured confounders biasing results?

Sean Maguire, Ruth Keogh, Elizabeth Williamson, John Tazare



DO GENETIC CHANGES IN 15Q13.3 MEAN LOWER IQ SCORE?

Tadas Žvirblis, Pilar Caro, Audronė Jakaitienė, Christian Schaaf



Measuring the performance of survival models to personalize treatment choices

Orestis Efthimiou, Jeroen Hoogland, Thomas Debray, Valerie Aponte Ribero, Wilma Knol, Huiberdina Koek, Matthias Schwenkglenks, Séverine Henrard, Matthias Egger, Nicolas Rodondi, Ian White



A framework for estimating quality adjusted life years using joint models of longitudinal and survival data

Michael Crowther, Alessandro Gasparini, Sara Ekberg, Federico Felizzi, Elaine Gallagher, Noman Paracha



Cut Off Determination using Model Derived Estimate in Survival Prediction Model

Jungbok Lee



A two-step testing approach for comparing time-to-event data under non-proportional hazards

Jonas Brugger, Tim Friede, Florian Klinglmüller, Martin Posch, Franz König



A systematic review of Bayesian survival modelling for extrapolating survival in cost-effectiveness analysis

Farah Erdogan, Gwénaël Le Teuff



Power comparison of hazard ratio versus restricted mean survival time in the presence of cure

Ronald Bertus Geskus



Sample Size Calculation in Prognostic Studies: A Comparative Analysis

Gloria Brigiari, Ester Rosa, Giulia Lorenzoni, Dario Gregori



Prognostic Score Adjustment in a Two-Slope Mixed Effects Model to Estimate Treatment Effects on eGFR Slope in CKD Patients

Silke Janitza, Maike Ahrens, Sebastian Voss, Bohdana Ratitch, Nicole Rethemeier, Meike Brinker, Paula Vesterinen, Antigoni Elefsinioti



Comparative effectiveness of ACE inhibitors and angiotensin receptor blockers to prevent or delay dementia: a target trial emulation

Marie-Laure Charpignon, Max Sunog, Colin Magdamo, Bella Vakulenko-Lagun, Ioanna Tzoulaki, Sudeshna Das, Deborah Blacker, Mark Albers



Optimal utility-based design of phase II/phase III programmes with different type of endpoints in the setting of multiple myeloma

Haotian Wang, Peter Kimani, Michael Grayling, Josephine Khan, Nigel Stallard



Beyond first events: Advancing recurrent adverse event estimates in clinical research.

Nicolas Sauvageot, Leen Slaets, Anirban Mitra, Zoe Craig, Jane Gilbert, Lilla Di Scala, Stefan Englert



Cure models to compare aftercare monitoring schemes in pediatric cancer

Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck



Comparison of treatment sequences in advanced pancreatic cancer

Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke



Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions

Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti



A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses

Martin Kappler, Yuan Ji



Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies

Vibha Srichand



Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials

Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar



Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study

Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan



Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies

Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida



Navigating complex and computationally demanding clinical trial simulation

Saumil Shah, Mitchell Thomann



Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms

Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera



Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making

Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder



Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations

Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder



Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis

Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT



Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY

Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo



Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care

Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori



Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana

Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe



Application of machine learning methods for the analysis of randomised controlled trials: A systematic review

Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani



Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates

Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka



Mediation analysis for exploring gender differences in mortality among acute myocardial infarction

Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi



Bivariate random-effects models for the meta-analysis of rare events

Danyu Li, Patrick Taffe



Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators

Yasuyuki Okuda, Masataka Taguri



Causal framework for analyzing mediation effects of clinical biomarkers

Jinesh Shah



A Modified Doubly Robust Estimator for Clustered Causal Inference: Integrating GLMM and GBM

Samina Naznin, Dr. Mohaimen Monsur



DoubleMLDeep: Estimation of Causal Effects with Multimodal Data

Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar



Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials

Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel



Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials

Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier



Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study

Nerissa Nance, Romain Neugebauer



Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio

Junxian Zhu, Mark Y. Chan, Bee-Choo Tai



Blinded sample size recalculation for randomized controlled trials with analysis of covariance

Takumi Kanata, Yasuhiro Hagiwara, Koji Oba



Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies

Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi



Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study

Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis



Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes

Shashank Tripathi, Rachna Agarwal



Optimal standardization as an alternative to matching using propensity scores

Ekkehard Glimm, Lillian Yau



Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias

Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones



Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review

Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan



WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations

Autumn O Donnell



Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials

Lillian Yau, Betty Molloy



Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach

Satomi OKAMURA, Eisuke HIDA



Adding baskets to an ongoing basket trial with information borrowing: When do you benefit?

Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki



Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions

Valeria Mazzanti, Dirk Klingbiel



N-of-1 Trials to Estimate Individual Effects of Music on Concentration

Thomas Gärtner, Fabian Stolp, Stefan Konigorski



Simulation Study Examining Impact of Study Design Factors on Variability Measures

Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch



Simulation-based optimization of adaptive designs using a generalized version of assurance

Pantelis Vlachos, Valeria Mazzanti, Boaz Adler



Evaluating the impact of outcome delay on adaptive designs

Aritra Mukherjee, Michael J. Grayling, James M. S. Wason


 
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