Conference Agenda

Developing a clinical prediction model with a continuous outcome: sample size calculations to target precise predictions

Rebecca Whittle, Richard D. Riley, Lucinda Archer, Gary S. Collins, Paula Dhiman, Amardeep Legha, Kym Snell, Joie Ensor

Sequential sample size calculations for developing clinical prediction models: learning curves suggest larger datasets are needed for individual-level stability

Amardeep Legha, Joie Ensor, Ben Van Calster, Evangelia Christodoulou, Lucinda Archer, Rebecca Whittle, Kym I.E. Snell, Paula Dhiman, Gary S. Collins, Richard D. Riley

Determining the Sample Size for Risk Prediction Models with Clustered Binary Data

Izzati Izyani Japar, Gareth Ambler, M. Shafiqur Rahman, Rumana Omar

Conformal prediction intervals for the individual treatment effect

Danijel Kivaranovic, Robin Ristl, Martin Posch, Hannes Leeb

Effective sample size for Cox survival models: A measure of individual uncertainty in predictions

Toby Hackmann, Doranne Thomassen, Saskia le Cessie, Hein Putter, Liesbeth C de Wreede, Ewout W Steyerberg

Assessing surrogacy from joint modelling and mediation analysis when surrogates are either censored event times or longitudinal biomarker: cancer application

Virginie RONDEAU, Quentin LECOENT, Catherine LEGRAND

Joint Modelling Using Semiparametric Accelerated Failure Time Approaches: Application to Health-Related Quality of Life Analysis

Ding Ma, Patrick Maher, Andrew Martin

Using Joint Models to Assess Delayed Initiation of Salvage Therapy following Biochemical Recurrence for Prostate Cancer.

Jeremy M G Taylor, Dimitris Rizopoulos, Lukas Owens

Faster Estimation of Quasi-Monte Carlo Methods for Joint Models of Multivariate Longitudinal Data and Penalized Cox Regression

Adeboye Azeez, Colin Noel

Regularization and Flexible Methods to Improve Complete Cancer Prevalence Predictions in the Prevalence Incidence Analysis Model

Fabrizio Di Mari, Roberta De Angelis, Therese ML Andersson, Enoch Yi-Tung Chen, Silvia Rossi, Paul W Dickman, Roberto Rocci, Mark Clements

Assessing diagnostic accuracy for three-class classification problems

Maria C. Pardo, Alba M. Franco-Pereira, Victor M. Sierra

Biological Age Estimation in the Estonian Biobank Based on NMR Metabolomics Data and Phenotype

Mara Delesa-Velina, Krista Fischer, Estonian Biobank Research Team

Bézier curve parametric method for approximating ROC curves in the context of multiple clinical decision thresholds

Denys Prociuk, Brendan Delaney, Francesca Fiorentino

Deriving Cost-effective Neyman-Pearson Classifier with Multiple-Modality Detection Tools

jiaming Qiu, Yingqi Zhao, Yingye Zheng

Improving Biomarker Diagnostic Accuracy with the Likelihood Ratio Transformation

Ainesh Sewak, Vanda Inacio

Blinded sample size re-estimation accounting for estimation error with small internal pilot studies

Hirotada Maeda, Satoshi Hattori, Tim Friede

Randomization in clinical trials with small sample sizes using group sequential designs

Daniel Bodden, Ralf-Dieter Hilgers, Franz König

Adjusting for allocation bias in stratified clinical trials with multi-component endpoints

Stefanie Schoenen, Ralf-Dieter Hilgers, Nicole Heussen

Methodological insights from the EPISTOP trial for designing and analysing clinical trials in rare diseases

Stephanie Wied, Ralf-Dieter Hilgers

Modified crossover trials to improve feasibility of evaluating multiple treatments for rare relapsing-remitting conditions

James Wason

Federated Inference methods for estimation and comparison of Standardized Mortality Ratios

Zoë D. van den Heuvel, Bas de Groot, Marianne A. Jonker

A mixture model for subtype identification: Application to CADASIL

Sofia Kaisaridi, Juliette Ortholand, Caglayan Tuna, Nicolas Gensollen, Sophie Tezenas du Montcel

Performance of a residual-based algorithm aiming at identifying response shift at the item level using Rasch models: a simulation study

Yseulys Dubuy, Victor Rechard, Véronique Sébille

Lifecourse modelling and time-varying covariates: empirical application and simulation study for novel method

Solomon Beer, Sherief Eldeeb, Erin Dunn, Andrew Simpkin, Andrew Smith

Emulating hypothetical interventions of physical activity on obesity: applying target trial emulation in the 1970 Birth Cohort Study

Michail Katsoulis, Jamie Wong

Quantifying the Clinical Usefulness of Novel Biomarkers and Tests: Beyond Traditional Statistics

Frank Doornkamp, Jelle J Goeman, Ewout W Steyerberg

The underlap coefficient as measure of a biomarker’s discriminatory ability in a multi-class disease setting

Zhaoxi Zhang, Vanda Inácio, Miguel de Carvalho

Time-dependent accuracy for Continuous Biomarkers using Copula Modelling

Adina Najwa Kamarudin, Ahmad Faiz Mohd Azhar, Nurain Ibrahim

Sample size determination for hypothesis testing of the intraclass correlation coefficient for agreement in two-way ANOVA models

Dipro Mondal, Alberto Cassese, Math JJM Candel, Sophie Vanbelle

Accounting for misclassification of binary outcomes in external control arm studies for unanchored indirect comparisons: simulations and applied example

Mikail Nourredine, Antoine Gavoille, Côme Lepage, Behrouz Kassai-Koupai, Michel Cucherat, Fabien Subtil

Handling informative patient monitoring in routinely-collected data used to estimate treatment effects, with application to high-frequency hospital data

Leah Pirondini, Karla Diaz-Ordaz, Ruth Keogh

Target Trial Emulation to Duplicate Randomized Clinical Trials using Registry Data in Multiple Sclerosis

Antoine Gavoille, Mikail Nourredine, Fabien Rollot, Romain Casey, Sandra Vukusic, Muriel Rabilloud, Fabien Subtil

Exploring Synthetic Control Data Quality Between Data Types in Two Case Studies: COVID-19 and Crohn’s Disease

Nicole Ann Cizauskas, Svetlana Cherlin, James Wason

The most appropriate method for outlier detection in a clinical audit depends on the data distribution

Anqi Sui, Menelaos Pavlou, Rumana Z. Omar, Gareth Ambler

Incorporating real-world data to refine the calculation of probability of success

Bergas Fayyad, Laura Rodwell, Kit Roes, Giulia Ferrannini, Christian Basile, Lars Lund, Gianluigi Savarese, Aysun Cetinyurek-Yavuz

Group measurement invariance assessment with item-level latent variable models: A comparative simulation study of two methods

Myriam Blanchin, Odile Stahl, Yseulys Dubuy, Véronique Sébille

Linkage of HIV treatment and population-based surveillance records in rural South Africa

Dickman Gareta, Evelyn Lauren, Khumbo Shumba, Cornelius Nattey, William Macleod, Matthew P. Fox, Koleka Mlisana, Matthias Egger, Dorina Onoya, Kobus Herbst, Jacob Bor

Investigating Statistical Inference for Consistency, Heterogeneity and Efficacy of Federated Learning Models: Insights from a Mega-Simulation of Real-World Data

Narayan Sharma, Gonzalo Durán-Pacheco, Jacek Chmiel, Eric Boernert, Doug Kelkhoff, Vittorio P. Illiano, Gabriele Zilorri, Matthias Antonin, Bjoern Tackenberg, Dominik Heinzmann

Characterizing Medication Timelines in Huntington’s Disease: A Cluster-Based Analysis of Treatment Patterns

Marc Dibling, Alexandra Durr, Sophie Tezenas du Montcel

Testing the Similarity of Healthcare Pathways based on Transition Probabilities - A New Bootstrap Procedure

Zoe Lange, Holger Dette, Maryam Farhadizadeh, Nadine Binder