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Conference Agenda

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Session Overview
Location: Biozentrum, 2nd floor Biozentrum, 2nd floor poster area

Date: Monday, 25/Aug/2025
10:45am - 11:30am	Poster Exhibition: M / Monday posters at Biozentrum Location: Biozentrum, 2nd floor Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud Information borrowing in phase II randomized dose-ranging clinical trials in oncology Guillaume Mulier, Vincent Lévy, Lucie Biard Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo A Bayesian approach to decision making in early development clinical trials : An R solution. Audrey Te-ying Yeo Designing Clinical Trials in R with rpact and crmPack Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke Leveraging on historical controls in the design and analysis of phase II clinical trials Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software Yannick Vandendijck, Christina Fillmore, Lyn Taylor Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel CUtools: an R package for clinical utility analysis of predictive models María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson Topic modelling and time-series analysis to explore methodological trend evolution Gabrielle Gauthier-Gagné, Tibor Schuster Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics Christos Christogiannis, Dimitris Mavridis Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study Corentin Choisy, Yseulys Dubuy, Véronique Sébille Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS) Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments Kotaro Sasaki, Hisashi Noma Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol Nadia Dardenne, Anh Diep, Anne-Françoise Donneau Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency Mi Mi Ko Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width Paul Talsma, Francesco Innocenti Sample size calculation methods for clinical trials using co-primary count endpoints Takuma Ishihara, Kouji Yamamoto Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials Hao Jiang, Yonghong Gao Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics Lucie Fayette, Karl Brendel, France Mentré Unbiased Estimation for Hierarchical Models in Clinical Trials Raiann Joanna Hamshaw, Nanxuan Lin Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann Bayesian bivariate analysis of phase II basket trials enabling borrowing of information Zhi Cao, Pavel Mozgunov, Haiyan Zheng Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod Yuki Fukuyama, Gosuke Homma, Masahiko Gosho Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables Vanessa Ihl, Ralf-Dieter Hilgers Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach Eisuke Hida, Satomi Okamura, Tomoharu Sato Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study Wenyue Li, Becky Turner, Duncan Gilbert, Ian White Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials. Teresa Engelbrecht, Alexandra Graf A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions Monika Jelizarow Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials Tomoharu Sato, Eisuke Hida Dealing with missing values in adaptive N-of-1 trials Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski Adaptive clinical trial design with delayed treatment effects using elicited prior distributions James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson
11:30am - 1:00pm	Poster Exhibition: M / Monday posters at Biozentrum Location: Biozentrum, 2nd floor Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud Information borrowing in phase II randomized dose-ranging clinical trials in oncology Guillaume Mulier, Vincent Lévy, Lucie Biard Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo A Bayesian approach to decision making in early development clinical trials : An R solution. Audrey Te-ying Yeo Designing Clinical Trials in R with rpact and crmPack Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke Leveraging on historical controls in the design and analysis of phase II clinical trials Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software Yannick Vandendijck, Christina Fillmore, Lyn Taylor Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel CUtools: an R package for clinical utility analysis of predictive models María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson Topic modelling and time-series analysis to explore methodological trend evolution Gabrielle Gauthier-Gagné, Tibor Schuster Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics Christos Christogiannis, Dimitris Mavridis Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study Corentin Choisy, Yseulys Dubuy, Véronique Sébille Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS) Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments Kotaro Sasaki, Hisashi Noma Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol Nadia Dardenne, Anh Diep, Anne-Françoise Donneau Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency Mi Mi Ko Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width Paul Talsma, Francesco Innocenti Sample size calculation methods for clinical trials using co-primary count endpoints Takuma Ishihara, Kouji Yamamoto Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials Hao Jiang, Yonghong Gao Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics Lucie Fayette, Karl Brendel, France Mentré Unbiased Estimation for Hierarchical Models in Clinical Trials Raiann Joanna Hamshaw, Nanxuan Lin Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann Bayesian bivariate analysis of phase II basket trials enabling borrowing of information Zhi Cao, Pavel Mozgunov, Haiyan Zheng Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod Yuki Fukuyama, Gosuke Homma, Masahiko Gosho Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables Vanessa Ihl, Ralf-Dieter Hilgers Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach Eisuke Hida, Satomi Okamura, Tomoharu Sato Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study Wenyue Li, Becky Turner, Duncan Gilbert, Ian White Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials. Teresa Engelbrecht, Alexandra Graf A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions Monika Jelizarow Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials Tomoharu Sato, Eisuke Hida Dealing with missing values in adaptive N-of-1 trials Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski Adaptive clinical trial design with delayed treatment effects using elicited prior distributions James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson
1:00pm - 2:00pm	Poster Exhibition: M / Monday posters at Biozentrum Location: Biozentrum, 2nd floor Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud Information borrowing in phase II randomized dose-ranging clinical trials in oncology Guillaume Mulier, Vincent Lévy, Lucie Biard Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo A Bayesian approach to decision making in early development clinical trials : An R solution. Audrey Te-ying Yeo Designing Clinical Trials in R with rpact and crmPack Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke Leveraging on historical controls in the design and analysis of phase II clinical trials Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software Yannick Vandendijck, Christina Fillmore, Lyn Taylor Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel CUtools: an R package for clinical utility analysis of predictive models María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson Topic modelling and time-series analysis to explore methodological trend evolution Gabrielle Gauthier-Gagné, Tibor Schuster Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics Christos Christogiannis, Dimitris Mavridis Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study Corentin Choisy, Yseulys Dubuy, Véronique Sébille Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS) Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments Kotaro Sasaki, Hisashi Noma Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol Nadia Dardenne, Anh Diep, Anne-Françoise Donneau Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency Mi Mi Ko Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width Paul Talsma, Francesco Innocenti Sample size calculation methods for clinical trials using co-primary count endpoints Takuma Ishihara, Kouji Yamamoto Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials Hao Jiang, Yonghong Gao Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics Lucie Fayette, Karl Brendel, France Mentré Unbiased Estimation for Hierarchical Models in Clinical Trials Raiann Joanna Hamshaw, Nanxuan Lin Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann Bayesian bivariate analysis of phase II basket trials enabling borrowing of information Zhi Cao, Pavel Mozgunov, Haiyan Zheng Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod Yuki Fukuyama, Gosuke Homma, Masahiko Gosho Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables Vanessa Ihl, Ralf-Dieter Hilgers Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach Eisuke Hida, Satomi Okamura, Tomoharu Sato Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study Wenyue Li, Becky Turner, Duncan Gilbert, Ian White Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials. Teresa Engelbrecht, Alexandra Graf A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions Monika Jelizarow Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials Tomoharu Sato, Eisuke Hida Dealing with missing values in adaptive N-of-1 trials Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski Adaptive clinical trial design with delayed treatment effects using elicited prior distributions James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson
2:00pm - 3:30pm	Poster Exhibition: M / Monday posters at Biozentrum Location: Biozentrum, 2nd floor Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud Information borrowing in phase II randomized dose-ranging clinical trials in oncology Guillaume Mulier, Vincent Lévy, Lucie Biard Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo A Bayesian approach to decision making in early development clinical trials : An R solution. Audrey Te-ying Yeo Designing Clinical Trials in R with rpact and crmPack Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke Leveraging on historical controls in the design and analysis of phase II clinical trials Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software Yannick Vandendijck, Christina Fillmore, Lyn Taylor Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel CUtools: an R package for clinical utility analysis of predictive models María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson Topic modelling and time-series analysis to explore methodological trend evolution Gabrielle Gauthier-Gagné, Tibor Schuster Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics Christos Christogiannis, Dimitris Mavridis Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study Corentin Choisy, Yseulys Dubuy, Véronique Sébille Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS) Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments Kotaro Sasaki, Hisashi Noma Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol Nadia Dardenne, Anh Diep, Anne-Françoise Donneau Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency Mi Mi Ko Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width Paul Talsma, Francesco Innocenti Sample size calculation methods for clinical trials using co-primary count endpoints Takuma Ishihara, Kouji Yamamoto Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials Hao Jiang, Yonghong Gao Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics Lucie Fayette, Karl Brendel, France Mentré Unbiased Estimation for Hierarchical Models in Clinical Trials Raiann Joanna Hamshaw, Nanxuan Lin Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann Bayesian bivariate analysis of phase II basket trials enabling borrowing of information Zhi Cao, Pavel Mozgunov, Haiyan Zheng Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod Yuki Fukuyama, Gosuke Homma, Masahiko Gosho Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables Vanessa Ihl, Ralf-Dieter Hilgers Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach Eisuke Hida, Satomi Okamura, Tomoharu Sato Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study Wenyue Li, Becky Turner, Duncan Gilbert, Ian White Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials. Teresa Engelbrecht, Alexandra Graf A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions Monika Jelizarow Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials Tomoharu Sato, Eisuke Hida Dealing with missing values in adaptive N-of-1 trials Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski Adaptive clinical trial design with delayed treatment effects using elicited prior distributions James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson
3:30pm - 4:00pm	Poster Exhibition: M / Monday posters at Biozentrum Location: Biozentrum, 2nd floor Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud Information borrowing in phase II randomized dose-ranging clinical trials in oncology Guillaume Mulier, Vincent Lévy, Lucie Biard Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo A Bayesian approach to decision making in early development clinical trials : An R solution. Audrey Te-ying Yeo Designing Clinical Trials in R with rpact and crmPack Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke Leveraging on historical controls in the design and analysis of phase II clinical trials Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software Yannick Vandendijck, Christina Fillmore, Lyn Taylor Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel CUtools: an R package for clinical utility analysis of predictive models María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson Topic modelling and time-series analysis to explore methodological trend evolution Gabrielle Gauthier-Gagné, Tibor Schuster Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics Christos Christogiannis, Dimitris Mavridis Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study Corentin Choisy, Yseulys Dubuy, Véronique Sébille Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS) Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments Kotaro Sasaki, Hisashi Noma Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol Nadia Dardenne, Anh Diep, Anne-Françoise Donneau Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency Mi Mi Ko Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width Paul Talsma, Francesco Innocenti Sample size calculation methods for clinical trials using co-primary count endpoints Takuma Ishihara, Kouji Yamamoto Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials Hao Jiang, Yonghong Gao Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics Lucie Fayette, Karl Brendel, France Mentré Unbiased Estimation for Hierarchical Models in Clinical Trials Raiann Joanna Hamshaw, Nanxuan Lin Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann Bayesian bivariate analysis of phase II basket trials enabling borrowing of information Zhi Cao, Pavel Mozgunov, Haiyan Zheng Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod Yuki Fukuyama, Gosuke Homma, Masahiko Gosho Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables Vanessa Ihl, Ralf-Dieter Hilgers Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach Eisuke Hida, Satomi Okamura, Tomoharu Sato Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study Wenyue Li, Becky Turner, Duncan Gilbert, Ian White Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials. Teresa Engelbrecht, Alexandra Graf A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions Monika Jelizarow Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials Tomoharu Sato, Eisuke Hida Dealing with missing values in adaptive N-of-1 trials Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski Adaptive clinical trial design with delayed treatment effects using elicited prior distributions James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson
4:00pm - 5:30pm	Poster Exhibition: M / Monday posters at Biozentrum Location: Biozentrum, 2nd floor Matching-adjusted indirect comparison of endoscopic and craniofacial resection for the treatment of sinonasal cancer invading the skull base Florian Chatelet, Sylvie Chevret, MUSES collaborative group, Philippe Herman, Benjamin Verillaud Information borrowing in phase II randomized dose-ranging clinical trials in oncology Guillaume Mulier, Vincent Lévy, Lucie Biard Information borrowing in Bayesian clinical trials: choice of tuning parameters for the robust mixture prior Vivienn Weru, Annette Kopp-Schneider, Manuel Wiesenfarth, Sebastian Weber, Silvia Calderazzo A Bayesian approach to decision making in early development clinical trials : An R solution. Audrey Te-ying Yeo Designing Clinical Trials in R with rpact and crmPack Daniel Sabanés Bové, Gernot Wassmer, Friedrich Pahlke Leveraging on historical controls in the design and analysis of phase II clinical trials Zhaojin Chen, Ross Andrew Soo, Bee Choo Tai Design of a research project to evaluate the statistical utility after transformation of a CDISC database into OMOP format Claire Castagné, Amélie Lambert, Jacek Chmiel, Alberto Labarga, Eric Boernert, Lukasz Kaczmarek, Francois Margraff, David Pau, Camille Bachot, Thomas Stone, Dimitar Toshev Introducing CAMIS: an open-source, community endeavor for Comparing Analysis Method Implementations in Software Yannick Vandendijck, Christina Fillmore, Lyn Taylor Assessing covariates influence on cure probability in mixture cure models using martingale difference correlation Blanca E. Monroy-Castillo, M. Amalia Jácome, Ricardo Cao Aligning Estimators to Treatment Effects in the presence of Intercurrent Events in the Analyses of Safety Outcomes Pedro Lopez-Romero, Brenda Crowe, Philip He, Natalia Kan-Dobrosky, Andreas Sashegyi, Jonathan Siegel CUtools: an R package for clinical utility analysis of predictive models María Escorihuela Sahún, Luis Marianos Esteban Escaño, Gerardo Sanz, Ángel Borque-Fernando Impact of Particulate Matter 2.5 Levels on Chronic Obstructive Pulmonary Disease: An Analysis of Nationwide Claims Data in Thailand Pawin Numthavaj, Tint Lwin Win, Chaiyawat Suppasilp, Wanchana Ponthongmak, Panu Looareesuwan, Suparee Boonmanunt, Oraluck Pattanaprateep, Prapaporn Pornsuriyasak, Chathaya Wongrathanandha, Kriengsak Vareesangthip, Phunchai Charatcharoenwitthaya, Atiporn Ingsathit, Ammarin Thakkinstian Changes in health services use of a cohort of COPD patients from a pre-pandemic to a COVID-19 pandemic period Jose M Quintana, Maria J Legarreta, Nere Larrea, Irantzu Barrio, Amaia Aramburu, Cristóbal Esteban The ISARIC Clinical Epidemiology Platform: Standardized Analytical Pipelines for Rapid Outbreak Response Esteban Garcia-Gallo, Tom Edinburgh, Sara Duque, Leonardo Bastos, Igor Tona Peres, Elise Pesonel, Laura Merson Topic modelling and time-series analysis to explore methodological trend evolution Gabrielle Gauthier-Gagné, Tibor Schuster Post-stroke facial palsy: prevalence on admission, risk factors, and recovery with hyperacute treatments Zewen Lu, Havva Sumeyye Eroglu, Halvor Næss, Matthew Gittins, Amit K Kishore, Craig J Smith, Andy Vail, Claire Mitchell Evaluating Outlier Detection Methods in Real-World Growth Data: A Sensitivity Analysis of Imperfect Data in a Cluster Randomised Controlled Trial Maryam Shojaei Shahrokhabadi, Mohadeseh Shojaei Shahrokhabadi, Bram Burger, Ashley J. Adamson, Dawn Teare Latent class analysis on intersectional social identities and mental wellbeing among ethnic minority youth in Aotearoa New Zealand Arier Lee, Shanthi Ameratunga, Rodrigo Ramalho, Rachel Simon-Kumar, Vartika Sharma, Renee Liang, Kristy Kang, Terryann Clark, Terry Fleming, Roshini Peiris-John Using multiple imputation in real-word data studies to aid in the identification of predictors of response while addressing missing data Jozefien Buyze, Lada Mitchell, Lorenzo Acciarri An imputation method for heterogeneous studies in Network Meta-Analysis: A Fully Conditional Specification approach using distance metrics Christos Christogiannis, Dimitris Mavridis Impact of lack of measurement invariance on causal inference in randomized controlled-trials including patient-reported outcome measures: a simulation study Corentin Choisy, Yseulys Dubuy, Véronique Sébille Evaluation of the Psychometric Qualities of Idiographic Patient Reported Outcome Measures (I-PROMs) for Patients Monitoring: PSYCHLOPS example Salma Ahmed Ayis, Luís Miguel Madeira Faísca, Célia Sales Bias in the estimation of a psychometric function when using the PSI-method under optimal conditions – a simulation study Simon Grøntved, Jakob Nebeling Hedegaard, Ib Thorsgaard Jensen, Daniel Skak Mazhari-Jensen Psychometric properties confirmation of the Multiple Sclerosis Autonomy Scale (MSAS) questionnaire evaluating patient autonomy in multiple sclerosis (MS) Cécile Donzé, Claude Mekies, Géraud Paillot, Lucie Brechenmacher, Alexandre Civet, David Pau, Delphine Chomette, Mikael Cohen, Catherine Mouzawak, Patrick Vermersch Learning heterogeneous treatment effect from multiple randomized trials to inform healthcare decision-making: implications and estimation methods Qingyang Shi, Veerle Coupé, Sacha la Bastide-van Gemert, Talitha Feenstra Multiple imputation of missing viral load measurements in HIV treatment trials: a comparison of strategies Tra My Pham, Deborah Ford, Anna Turkova, Man Chan, Ralph DeMasi, Yongwei Wang, Jenny O Huang, Qiming Liao, James R Carpenter, Ian R White A novel approach for assessing inconsistency in network meta-analysis: Application to comparative effectiveness analysis of antihypertensive treatments Kotaro Sasaki, Hisashi Noma Investigating (bio)statistical literacy among health researchers in a Belgian university context: A framework and study protocol Nadia Dardenne, Anh Diep, Anne-Françoise Donneau Balneotherapy for Peripheral Vascular Diseases: A Systematic Review with a Focus on Peripheral Arterial Disease and Chronic Venous Insufficiency Mi Mi Ko Binomial Sum Variance Inequality correction of 95% CIs of percentages in multicentre studies ensures approximately 95% coverage with minimal width Paul Talsma, Francesco Innocenti Sample size calculation methods for clinical trials using co-primary count endpoints Takuma Ishihara, Kouji Yamamoto Analysis of Composite Endpoint in Cardiovascular Device Clinical Trials Hao Jiang, Yonghong Gao Bayesian predictive monitoring using two-dimensional index for single-arm trial with bivariate binary outcomes Takuya Yoshimoto, Satoru Shinoda, Kouji Yamamoto, Kouji Tahata Optimising covariate allocation at design stage using Fisher Information Matrix for Non-Linear Mixed Effects Models in pharmacometrics Lucie Fayette, Karl Brendel, France Mentré Unbiased Estimation for Hierarchical Models in Clinical Trials Raiann Joanna Hamshaw, Nanxuan Lin Sample size re-estimation for McNemar's test in a prospective randomized clinical trial on childhood glaucoma Markus Schepers, Esther Hoffmann, Julia Stingl, Anne Ehrlich, Claudia Wolf, Thomas Dietlein, Ingeborg Stalmans, Irene Schmidtmann Bayesian bivariate analysis of phase II basket trials enabling borrowing of information Zhi Cao, Pavel Mozgunov, Haiyan Zheng Usefulness of the blinded sample size re-estimation for dose-response trials with MCP-Mod Yuki Fukuyama, Gosuke Homma, Masahiko Gosho Quantification of allocation bias in clinical trials under a response-adaptive randomization procedure for binary response variables Vanessa Ihl, Ralf-Dieter Hilgers Assessment of Assay Sensitivity in Non-Inferiority Trials Using Aggregate Data from a Historical Trial: A Population Adjustment Approach Eisuke Hida, Satomi Okamura, Tomoharu Sato Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial: a simulation study Wenyue Li, Becky Turner, Duncan Gilbert, Ian White Comparing The ED50 Between Treatment Groups Using Sequential Allocation Trials. Teresa Engelbrecht, Alexandra Graf A pre-study look into post-study knowledge: communicating the use(fulness) of pre-posteriors in early development design discussions Monika Jelizarow Estimation and testing methods for delayed-start design as an alternative to single-arm trials in small clinical trials Tomoharu Sato, Eisuke Hida Dealing with missing values in adaptive N-of-1 trials Juliana Schneider, Maliha Raihan Pranti, Stefan Konigorski Adaptive clinical trial design with delayed treatment effects using elicited prior distributions James Salsbury, Jeremy Oakley, Steven Julious, Lisa Hampson

Date: Tuesday, 26/Aug/2025
8:45am - 9:15am	Poster Exhibition: T / Tuesday posters at Biozentrum Location: Biozentrum, 2nd floor Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson Development and validation of prognostic models in phase I oncology clinical trials Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration Luca Genetti, Andrea Nizzardo, Marco Pergher Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials XINGZHI XU, SATOSHI HATTORI Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints Go Horiguchi, Isao Yokota, Satoshi Teramukai Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap Estimands in platform trials with time - treatment interactions ZIYAN WANG, Dave Woods A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess Optimizing Biomarker-Based Enrichment strategies in clinical trials Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun Leveraging Synthetic Data for Enhanced Clinical Research Outcomes Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL Byoung Ha Yoon Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards. Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott Automating Report Generation with Stata: A Case Study of NORUSE Maria Elstad Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis. MOHAMMED ABDU MUDAWI Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes Mahru Ahmad, Jack Wilkinson, Andy Vail Causal discovery for multi-cohort studies Christine Bang, Vanessa Didelez Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms A F M Tahsin Shahriar, AHM Mahbub-ul Latif Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao Revisiting subgroup analysis: A reflection on health disparities using conditional independence Nia Kang, Tibor Schuster Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study Jingya Zhao, Gareth Ambler, Baptiste Leurent Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods. Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial. Robin Young, Alex McConnachie, Helen Minnis The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation Gregory Chen, Micahel Seo, Isaac Gravestock Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials Patrick Djidel, Armand Chouzy, Pierre Colin Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock Power calculation using the win-ratio for composite outcomes in randomized trials David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held Feasibility of propensity score weighted analysis in rare disease trials: a simulation study Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini A basket trial for rare diseases, with a crossover design for its substudies: a simulation study Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials Anjali Yadav
9:15am - 10:45am	Poster Exhibition: T / Tuesday posters at Biozentrum Location: Biozentrum, 2nd floor Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson Development and validation of prognostic models in phase I oncology clinical trials Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration Luca Genetti, Andrea Nizzardo, Marco Pergher Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials XINGZHI XU, SATOSHI HATTORI Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints Go Horiguchi, Isao Yokota, Satoshi Teramukai Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap Estimands in platform trials with time - treatment interactions ZIYAN WANG, Dave Woods A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess Optimizing Biomarker-Based Enrichment strategies in clinical trials Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun Leveraging Synthetic Data for Enhanced Clinical Research Outcomes Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL Byoung Ha Yoon Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards. Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott Automating Report Generation with Stata: A Case Study of NORUSE Maria Elstad Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis. MOHAMMED ABDU MUDAWI Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes Mahru Ahmad, Jack Wilkinson, Andy Vail Causal discovery for multi-cohort studies Christine Bang, Vanessa Didelez Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms A F M Tahsin Shahriar, AHM Mahbub-ul Latif Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao Revisiting subgroup analysis: A reflection on health disparities using conditional independence Nia Kang, Tibor Schuster Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study Jingya Zhao, Gareth Ambler, Baptiste Leurent Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods. Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial. Robin Young, Alex McConnachie, Helen Minnis The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation Gregory Chen, Micahel Seo, Isaac Gravestock Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials Patrick Djidel, Armand Chouzy, Pierre Colin Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock Power calculation using the win-ratio for composite outcomes in randomized trials David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held Feasibility of propensity score weighted analysis in rare disease trials: a simulation study Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini A basket trial for rare diseases, with a crossover design for its substudies: a simulation study Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials Anjali Yadav
10:45am - 11:30am	Poster Exhibition: T / Tuesday posters at Biozentrum Location: Biozentrum, 2nd floor Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson Development and validation of prognostic models in phase I oncology clinical trials Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration Luca Genetti, Andrea Nizzardo, Marco Pergher Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials XINGZHI XU, SATOSHI HATTORI Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints Go Horiguchi, Isao Yokota, Satoshi Teramukai Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap Estimands in platform trials with time - treatment interactions ZIYAN WANG, Dave Woods A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess Optimizing Biomarker-Based Enrichment strategies in clinical trials Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun Leveraging Synthetic Data for Enhanced Clinical Research Outcomes Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL Byoung Ha Yoon Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards. Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott Automating Report Generation with Stata: A Case Study of NORUSE Maria Elstad Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis. MOHAMMED ABDU MUDAWI Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes Mahru Ahmad, Jack Wilkinson, Andy Vail Causal discovery for multi-cohort studies Christine Bang, Vanessa Didelez Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms A F M Tahsin Shahriar, AHM Mahbub-ul Latif Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao Revisiting subgroup analysis: A reflection on health disparities using conditional independence Nia Kang, Tibor Schuster Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study Jingya Zhao, Gareth Ambler, Baptiste Leurent Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods. Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial. Robin Young, Alex McConnachie, Helen Minnis The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation Gregory Chen, Micahel Seo, Isaac Gravestock Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials Patrick Djidel, Armand Chouzy, Pierre Colin Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock Power calculation using the win-ratio for composite outcomes in randomized trials David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held Feasibility of propensity score weighted analysis in rare disease trials: a simulation study Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini A basket trial for rare diseases, with a crossover design for its substudies: a simulation study Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials Anjali Yadav
11:30am - 1:00pm	Poster Exhibition: T / Tuesday posters at Biozentrum Location: Biozentrum, 2nd floor Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson Development and validation of prognostic models in phase I oncology clinical trials Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration Luca Genetti, Andrea Nizzardo, Marco Pergher Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials XINGZHI XU, SATOSHI HATTORI Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints Go Horiguchi, Isao Yokota, Satoshi Teramukai Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap Estimands in platform trials with time - treatment interactions ZIYAN WANG, Dave Woods A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess Optimizing Biomarker-Based Enrichment strategies in clinical trials Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun Leveraging Synthetic Data for Enhanced Clinical Research Outcomes Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL Byoung Ha Yoon Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards. Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott Automating Report Generation with Stata: A Case Study of NORUSE Maria Elstad Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis. MOHAMMED ABDU MUDAWI Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes Mahru Ahmad, Jack Wilkinson, Andy Vail Causal discovery for multi-cohort studies Christine Bang, Vanessa Didelez Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms A F M Tahsin Shahriar, AHM Mahbub-ul Latif Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao Revisiting subgroup analysis: A reflection on health disparities using conditional independence Nia Kang, Tibor Schuster Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study Jingya Zhao, Gareth Ambler, Baptiste Leurent Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods. Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial. Robin Young, Alex McConnachie, Helen Minnis The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation Gregory Chen, Micahel Seo, Isaac Gravestock Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials Patrick Djidel, Armand Chouzy, Pierre Colin Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock Power calculation using the win-ratio for composite outcomes in randomized trials David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held Feasibility of propensity score weighted analysis in rare disease trials: a simulation study Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini A basket trial for rare diseases, with a crossover design for its substudies: a simulation study Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials Anjali Yadav
1:00pm - 2:00pm	Poster Exhibition: T / Tuesday posters at Biozentrum Location: Biozentrum, 2nd floor Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson Development and validation of prognostic models in phase I oncology clinical trials Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration Luca Genetti, Andrea Nizzardo, Marco Pergher Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials XINGZHI XU, SATOSHI HATTORI Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints Go Horiguchi, Isao Yokota, Satoshi Teramukai Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap Estimands in platform trials with time - treatment interactions ZIYAN WANG, Dave Woods A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess Optimizing Biomarker-Based Enrichment strategies in clinical trials Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun Leveraging Synthetic Data for Enhanced Clinical Research Outcomes Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL Byoung Ha Yoon Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards. Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott Automating Report Generation with Stata: A Case Study of NORUSE Maria Elstad Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis. MOHAMMED ABDU MUDAWI Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes Mahru Ahmad, Jack Wilkinson, Andy Vail Causal discovery for multi-cohort studies Christine Bang, Vanessa Didelez Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms A F M Tahsin Shahriar, AHM Mahbub-ul Latif Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao Revisiting subgroup analysis: A reflection on health disparities using conditional independence Nia Kang, Tibor Schuster Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study Jingya Zhao, Gareth Ambler, Baptiste Leurent Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods. Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial. Robin Young, Alex McConnachie, Helen Minnis The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation Gregory Chen, Micahel Seo, Isaac Gravestock Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials Patrick Djidel, Armand Chouzy, Pierre Colin Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock Power calculation using the win-ratio for composite outcomes in randomized trials David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held Feasibility of propensity score weighted analysis in rare disease trials: a simulation study Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini A basket trial for rare diseases, with a crossover design for its substudies: a simulation study Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials Anjali Yadav

Date: Wednesday, 27/Aug/2025
9:00am - 10:30am	Poster Exhibition: W / Wednesday posters at Biozentrum Location: Biozentrum, 2nd floor Cure models to compare aftercare monitoring schemes in pediatric cancer Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck Comparison of treatment sequences in advanced pancreatic cancer Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses Martin Kappler, Yuan Ji Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies Vibha Srichand Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida Navigating complex and computationally demanding clinical trial simulation Saumil Shah, Mitchell Thomann Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe Application of machine learning methods for the analysis of randomised controlled trials: A systematic review Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka Mediation analysis for exploring gender differences in mortality among acute myocardial infarction Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi Bivariate random-effects models for the meta-analysis of rare events Danyu Li, Patrick Taffe Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators Yasuyuki Okuda, Masataka Taguri Causal framework for analyzing mediation effects of clinical biomarkers Jinesh Shah DoubleMLDeep: Estimation of Causal Effects with Multimodal Data Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study Nerissa Nance, Romain Neugebauer Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio Junxian Zhu, Mark Y. Chan, Bee-Choo Tai Blinded sample size recalculation for randomized controlled trials with analysis of covariance Takumi Kanata, Yasuhiro Hagiwara, Koji Oba Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes Shashank Tripathi, Rachna Agarwal Optimal standardization as an alternative to matching using propensity scores Ekkehard Glimm, Lillian Yau Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations Autumn O Donnell Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials Lillian Yau, Betty Molloy Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach Satomi OKAMURA, Eisuke HIDA Adding baskets to an ongoing basket trial with information borrowing: When do you benefit? Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions Valeria Mazzanti, Dirk Klingbiel N-of-1 Trials to Estimate Individual Effects of Music on Concentration Thomas Gärtner, Fabian Stolp, Stefan Konigorski Simulation Study Examining Impact of Study Design Factors on Variability Measures Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch Simulation-based optimization of adaptive designs using a generalized version of assurance Pantelis Vlachos, Valeria Mazzanti, Boaz Adler Evaluating the impact of outcome delay on adaptive designs Aritra Mukherjee, Michael J. Grayling, James M. S. Wason
10:30am - 11:00am	Poster Exhibition: W / Wednesday posters at Biozentrum Location: Biozentrum, 2nd floor Cure models to compare aftercare monitoring schemes in pediatric cancer Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck Comparison of treatment sequences in advanced pancreatic cancer Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses Martin Kappler, Yuan Ji Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies Vibha Srichand Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida Navigating complex and computationally demanding clinical trial simulation Saumil Shah, Mitchell Thomann Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe Application of machine learning methods for the analysis of randomised controlled trials: A systematic review Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka Mediation analysis for exploring gender differences in mortality among acute myocardial infarction Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi Bivariate random-effects models for the meta-analysis of rare events Danyu Li, Patrick Taffe Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators Yasuyuki Okuda, Masataka Taguri Causal framework for analyzing mediation effects of clinical biomarkers Jinesh Shah DoubleMLDeep: Estimation of Causal Effects with Multimodal Data Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study Nerissa Nance, Romain Neugebauer Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio Junxian Zhu, Mark Y. Chan, Bee-Choo Tai Blinded sample size recalculation for randomized controlled trials with analysis of covariance Takumi Kanata, Yasuhiro Hagiwara, Koji Oba Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes Shashank Tripathi, Rachna Agarwal Optimal standardization as an alternative to matching using propensity scores Ekkehard Glimm, Lillian Yau Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations Autumn O Donnell Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials Lillian Yau, Betty Molloy Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach Satomi OKAMURA, Eisuke HIDA Adding baskets to an ongoing basket trial with information borrowing: When do you benefit? Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions Valeria Mazzanti, Dirk Klingbiel N-of-1 Trials to Estimate Individual Effects of Music on Concentration Thomas Gärtner, Fabian Stolp, Stefan Konigorski Simulation Study Examining Impact of Study Design Factors on Variability Measures Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch Simulation-based optimization of adaptive designs using a generalized version of assurance Pantelis Vlachos, Valeria Mazzanti, Boaz Adler Evaluating the impact of outcome delay on adaptive designs Aritra Mukherjee, Michael J. Grayling, James M. S. Wason
12:15pm - 1:30pm	Poster Exhibition: W / Wednesday posters at Biozentrum Location: Biozentrum, 2nd floor Cure models to compare aftercare monitoring schemes in pediatric cancer Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck Comparison of treatment sequences in advanced pancreatic cancer Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses Martin Kappler, Yuan Ji Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies Vibha Srichand Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida Navigating complex and computationally demanding clinical trial simulation Saumil Shah, Mitchell Thomann Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe Application of machine learning methods for the analysis of randomised controlled trials: A systematic review Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka Mediation analysis for exploring gender differences in mortality among acute myocardial infarction Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi Bivariate random-effects models for the meta-analysis of rare events Danyu Li, Patrick Taffe Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators Yasuyuki Okuda, Masataka Taguri Causal framework for analyzing mediation effects of clinical biomarkers Jinesh Shah DoubleMLDeep: Estimation of Causal Effects with Multimodal Data Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study Nerissa Nance, Romain Neugebauer Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio Junxian Zhu, Mark Y. Chan, Bee-Choo Tai Blinded sample size recalculation for randomized controlled trials with analysis of covariance Takumi Kanata, Yasuhiro Hagiwara, Koji Oba Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes Shashank Tripathi, Rachna Agarwal Optimal standardization as an alternative to matching using propensity scores Ekkehard Glimm, Lillian Yau Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations Autumn O Donnell Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials Lillian Yau, Betty Molloy Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach Satomi OKAMURA, Eisuke HIDA Adding baskets to an ongoing basket trial with information borrowing: When do you benefit? Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions Valeria Mazzanti, Dirk Klingbiel N-of-1 Trials to Estimate Individual Effects of Music on Concentration Thomas Gärtner, Fabian Stolp, Stefan Konigorski Simulation Study Examining Impact of Study Design Factors on Variability Measures Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch Simulation-based optimization of adaptive designs using a generalized version of assurance Pantelis Vlachos, Valeria Mazzanti, Boaz Adler Evaluating the impact of outcome delay on adaptive designs Aritra Mukherjee, Michael J. Grayling, James M. S. Wason
1:00pm - 2:00pm	Poster Exhibition: W / Wednesday posters at Biozentrum Location: Biozentrum, 2nd floor Cure models to compare aftercare monitoring schemes in pediatric cancer Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck Comparison of treatment sequences in advanced pancreatic cancer Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses Martin Kappler, Yuan Ji Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies Vibha Srichand Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida Navigating complex and computationally demanding clinical trial simulation Saumil Shah, Mitchell Thomann Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe Application of machine learning methods for the analysis of randomised controlled trials: A systematic review Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka Mediation analysis for exploring gender differences in mortality among acute myocardial infarction Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi Bivariate random-effects models for the meta-analysis of rare events Danyu Li, Patrick Taffe Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators Yasuyuki Okuda, Masataka Taguri Causal framework for analyzing mediation effects of clinical biomarkers Jinesh Shah DoubleMLDeep: Estimation of Causal Effects with Multimodal Data Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study Nerissa Nance, Romain Neugebauer Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio Junxian Zhu, Mark Y. Chan, Bee-Choo Tai Blinded sample size recalculation for randomized controlled trials with analysis of covariance Takumi Kanata, Yasuhiro Hagiwara, Koji Oba Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes Shashank Tripathi, Rachna Agarwal Optimal standardization as an alternative to matching using propensity scores Ekkehard Glimm, Lillian Yau Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations Autumn O Donnell Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials Lillian Yau, Betty Molloy Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach Satomi OKAMURA, Eisuke HIDA Adding baskets to an ongoing basket trial with information borrowing: When do you benefit? Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions Valeria Mazzanti, Dirk Klingbiel N-of-1 Trials to Estimate Individual Effects of Music on Concentration Thomas Gärtner, Fabian Stolp, Stefan Konigorski Simulation Study Examining Impact of Study Design Factors on Variability Measures Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch Simulation-based optimization of adaptive designs using a generalized version of assurance Pantelis Vlachos, Valeria Mazzanti, Boaz Adler Evaluating the impact of outcome delay on adaptive designs Aritra Mukherjee, Michael J. Grayling, James M. S. Wason
2:00pm - 3:30pm	Poster Exhibition: W / Wednesday posters at Biozentrum Location: Biozentrum, 2nd floor Cure models to compare aftercare monitoring schemes in pediatric cancer Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck Comparison of treatment sequences in advanced pancreatic cancer Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses Martin Kappler, Yuan Ji Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies Vibha Srichand Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida Navigating complex and computationally demanding clinical trial simulation Saumil Shah, Mitchell Thomann Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe Application of machine learning methods for the analysis of randomised controlled trials: A systematic review Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka Mediation analysis for exploring gender differences in mortality among acute myocardial infarction Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi Bivariate random-effects models for the meta-analysis of rare events Danyu Li, Patrick Taffe Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators Yasuyuki Okuda, Masataka Taguri Causal framework for analyzing mediation effects of clinical biomarkers Jinesh Shah DoubleMLDeep: Estimation of Causal Effects with Multimodal Data Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study Nerissa Nance, Romain Neugebauer Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio Junxian Zhu, Mark Y. Chan, Bee-Choo Tai Blinded sample size recalculation for randomized controlled trials with analysis of covariance Takumi Kanata, Yasuhiro Hagiwara, Koji Oba Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes Shashank Tripathi, Rachna Agarwal Optimal standardization as an alternative to matching using propensity scores Ekkehard Glimm, Lillian Yau Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations Autumn O Donnell Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials Lillian Yau, Betty Molloy Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach Satomi OKAMURA, Eisuke HIDA Adding baskets to an ongoing basket trial with information borrowing: When do you benefit? Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions Valeria Mazzanti, Dirk Klingbiel N-of-1 Trials to Estimate Individual Effects of Music on Concentration Thomas Gärtner, Fabian Stolp, Stefan Konigorski Simulation Study Examining Impact of Study Design Factors on Variability Measures Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch Simulation-based optimization of adaptive designs using a generalized version of assurance Pantelis Vlachos, Valeria Mazzanti, Boaz Adler Evaluating the impact of outcome delay on adaptive designs Aritra Mukherjee, Michael J. Grayling, James M. S. Wason
3:30pm - 4:00pm	Poster Exhibition: W / Wednesday posters at Biozentrum Location: Biozentrum, 2nd floor Cure models to compare aftercare monitoring schemes in pediatric cancer Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck Comparison of treatment sequences in advanced pancreatic cancer Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses Martin Kappler, Yuan Ji Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies Vibha Srichand Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida Navigating complex and computationally demanding clinical trial simulation Saumil Shah, Mitchell Thomann Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe Application of machine learning methods for the analysis of randomised controlled trials: A systematic review Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka Mediation analysis for exploring gender differences in mortality among acute myocardial infarction Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi Bivariate random-effects models for the meta-analysis of rare events Danyu Li, Patrick Taffe Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators Yasuyuki Okuda, Masataka Taguri Causal framework for analyzing mediation effects of clinical biomarkers Jinesh Shah DoubleMLDeep: Estimation of Causal Effects with Multimodal Data Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study Nerissa Nance, Romain Neugebauer Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio Junxian Zhu, Mark Y. Chan, Bee-Choo Tai Blinded sample size recalculation for randomized controlled trials with analysis of covariance Takumi Kanata, Yasuhiro Hagiwara, Koji Oba Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes Shashank Tripathi, Rachna Agarwal Optimal standardization as an alternative to matching using propensity scores Ekkehard Glimm, Lillian Yau Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations Autumn O Donnell Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials Lillian Yau, Betty Molloy Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach Satomi OKAMURA, Eisuke HIDA Adding baskets to an ongoing basket trial with information borrowing: When do you benefit? Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions Valeria Mazzanti, Dirk Klingbiel N-of-1 Trials to Estimate Individual Effects of Music on Concentration Thomas Gärtner, Fabian Stolp, Stefan Konigorski Simulation Study Examining Impact of Study Design Factors on Variability Measures Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch Simulation-based optimization of adaptive designs using a generalized version of assurance Pantelis Vlachos, Valeria Mazzanti, Boaz Adler Evaluating the impact of outcome delay on adaptive designs Aritra Mukherjee, Michael J. Grayling, James M. S. Wason
4:00pm - 5:30pm	Poster Exhibition: W / Wednesday posters at Biozentrum Location: Biozentrum, 2nd floor Cure models to compare aftercare monitoring schemes in pediatric cancer Ulrike Pötschger, Harm van Tinteren, Evgenia Glogova, Helga Arnardottir, Paulina Kurzmann, Sabine Taschner-Mandl, Lieve Titgat, Martina Mittlböck Comparison of treatment sequences in advanced pancreatic cancer Norbert Marschner, Nina Haug, Susanna Hegewisch-Becker, Marcel Reiser, Steffen Dörfel, Rüdiger Liersch, Hartmut Linde, Thomas Wolf, Anna Hof, Anja Kaiser-Osterhues, Karin Potthoff, Martina Jänicke Clinical Trials with Time-to-event-endpoint: Interim Prediction of Number of Events with Confidence Distributions Edoardo Ratti, Maria Grazia Valsecchi, Stefania Galimberti A Bayesian-Informed Dose-Escalation Design for Multi-Cohort Oncology Trials with Varying Maximum Tolerated Doses Martin Kappler, Yuan Ji Comparison of Bayesian Approaches in Single-Agent Dose-Finding Studies Vibha Srichand Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials Chris J Selman, Katherine J Lee, Michael Dymock, Ian Marschner, Steven Y.C. Tong, Mark Jones, Tom Snelling, Robert K Mahar Bayesian decision analysis for clinical trial design with binary outcome in the context of Ebola Virus Disease outbreak – Simulation study Drifa Belhadi, Joonhyuk Cho, Pauline Manchon, Denis Malvy, France Mentré, Andrew W Lo, Cédric Laouénan Relevance of Electronic Medical Records for Clinical Trial Eligibility: A Feasibility Assessment in Acute Stroke Studies Yusuke Sasahara, Taizo Murata, Yasufumi Gon, Toshihiro Takeda, Eisuke Hida Navigating complex and computationally demanding clinical trial simulation Saumil Shah, Mitchell Thomann Transforming Clinical Trials: The Power of Synthetic Data in Augmenting Control Arms Emmanuelle Boutmy, Shane O Meachair, Julie Zhang, Sabrina de Souza, Saheli Das, Dina Oksen, Anna Tafuri, Lucy Mosquera Integrating stakeholder perspectives in modeling routine data for therapeutic decision-making Michelle Pfaffenlehner, Andrea Dreßing, Dietrich Knoerzer, Markus Wagner, Peter Heuschmann, André Scherag, Harald Binder, Nadine Binder Aligning Synthetic Trajectories from Expert-Based Models with Real Patient Data Using Low-Dimensional Representations Hanning Yang, Meropi Karakioulaki, Cristina Has, Moritz Hess, Harald Binder Integrating semantic information in care pathway studies with medical code embeddings, application to the case of Amyotrophic Lateral Sclerosis Corentin FAUJOUR, Stéphane BOUEE, Corinne EMERY, Anne-Sophie JANNOT Inequalities in impact of respiratory viruses: development and analysis of respiratory virus phenotypes in EHRs from England using OpenSAFELY Em Prestige, Jennifer K. Quint, Charlotte Warren-Gash, William Hulme, Edward PK Parker, Elizabeth Williamson, Rosalind M. Eggo Modeling Longitudinal Clinical Outcomes: Comparison of Generalized Linear Models, Generalized Estimating Equations, and Marginalized Multilevel Models in Pediatric Intensive Care Luca Vedovelli, Stefania Lando, Danila Azzolina, Corrado Lanera, Ileana Baldi, Dario Gregori Modelling the costeffectiveness of Truvada for the Prevention of Mother to Child Prevention (PMTCT) of Hepatitis B Virus in Botswana Graceful Mulenga, Motswedi Anderson, Simani Gaseitsiwe Application of machine learning methods for the analysis of randomised controlled trials: A systematic review Xiao Xuan Tan, Rachel Phillips, Mansour Taghavi Azar Sharabiani Joint longitudinal modelling of non-normally distributed outcomes and endogenous covariates Chiara Degan, Bart Mertens, Pietro Spitali, Erik H. Niks, Jelle Goeman, Roula Tsonaka Mediation analysis for exploring gender differences in mortality among acute myocardial infarction Alice Bonomi, Arianna Galotta, Francesco Maria Mattio, Lorenzo Cangiano, Giancarlo Marenzi Bivariate random-effects models for the meta-analysis of rare events Danyu Li, Patrick Taffe Time-varying Decomposition of Direct and Indirect Effects with Multiple Longitudinal Mediators Yasuyuki Okuda, Masataka Taguri Causal framework for analyzing mediation effects of clinical biomarkers Jinesh Shah DoubleMLDeep: Estimation of Causal Effects with Multimodal Data Martin Spindler, Victor Chernozhukov, Philipp Bach, Jan Teichert-Kluge, Sven Klaassen, Suhas Vijaykumar Causal Machine Learning Methods for Estimating Personalised Treatment Effects - Insights on validity from two large trials Hongruyu Chen, Helena Aebersold, Milo Alan Puhan, Miquel Serra-Burriel Challenges with subgroup analyses in individual participant data meta-analysis of randomised trials Alain Amstutz, Dominique Costagliola, Corina S. Rueegg, Erica Ponzi, Johannes M. Schwenke, France Mentré, Clément R. Massonnaud, Cédric Laouénan, Aliou Baldé, Lambert Assoumou, Inge C. Olsen, Matthias Briel, Stefan Schandelmaier Illustration and evaluation of a causal approach to sensitivity analysis for unmeasured confounding using measured proxies with a simulation study Nerissa Nance, Romain Neugebauer Quantifying causal treatment effect on binary outcome in RCTs with noncompliance: estimating risk difference, risk ratio and odds ratio Junxian Zhu, Mark Y. Chan, Bee-Choo Tai Blinded sample size recalculation for randomized controlled trials with analysis of covariance Takumi Kanata, Yasuhiro Hagiwara, Koji Oba Variance stabilization transformation for the intraclass correlation coefficient of agreement with an application example to meta-analyses of inter-rater reliability studies Abderrahmane Bourredjem, Isabelle Fournel, Sophie Vanbelle, Nadjia El Saadi Bridging Single Arm Studies with Individual Participant Data in Network Meta-Analysis of Randomized Controlled Trials: A Simulation Study Katerina Maria Kontouli, Stavros Nikolakopoulos, Christos Christogiannis, Dimitrios Mavridis Comparative Efficacy and Safety of Migraine Treatments: A Network Meta-Analysis of Clinical Outcomes Shashank Tripathi, Rachna Agarwal Optimal standardization as an alternative to matching using propensity scores Ekkehard Glimm, Lillian Yau Evaluating Diagnostic Tests Against Composite Reference Standards: Quantifying and Adjusting for Bias Vera Hudak, Nicky J. Welton, Efthymia Derezea, Hayley Jones Characteristics, Design and Statistical Methods in Platform Trials: A Systematic Review Clément R. Massonnaud, Christof Manuel Schönenberger, Malena Chiaborelli, Selina Ehrenzeller, Alexandra Griessbach, André Gillibert, Matthias Briel, Cédric Laouénan WRestimates: An R Package for Win-Ratio Sample Size and Power Calculations Autumn O Donnell Randomizing With Investigator Choice of Treatment: A Powerful Pragmatic Tool in Clinical Trials Lillian Yau, Betty Molloy Confirming assay sensitivity in 2-arm non-inferiority trial using meta-analytic-predictive approach Satomi OKAMURA, Eisuke HIDA Adding baskets to an ongoing basket trial with information borrowing: When do you benefit? Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun Bedding, Thomas Jaki Optimizing Adaptive Trial Design to Ensure Robustness Across Varying Treatment Effect Assumptions Valeria Mazzanti, Dirk Klingbiel N-of-1 Trials to Estimate Individual Effects of Music on Concentration Thomas Gärtner, Fabian Stolp, Stefan Konigorski Simulation Study Examining Impact of Study Design Factors on Variability Measures Laura Quinn, Jon Deeks, Yemisi Takwoingi, Alice Sitch Simulation-based optimization of adaptive designs using a generalized version of assurance Pantelis Vlachos, Valeria Mazzanti, Boaz Adler Evaluating the impact of outcome delay on adaptive designs Aritra Mukherjee, Michael J. Grayling, James M. S. Wason