Conference Agenda

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

 
 
Session Overview
Date: Tuesday, 26/Aug/2025
8:45am
-
9:15am
Poster Exhibition: T / Tuesday posters
Location: Poster Location
 

Leveraging Wearable data for Probabilistic Imputation in Cardiovascular Risk Calculators.

Antoine Faul, Patric Wyss, Anja Mühlemann, Manuela Moraru, Danielle Bower, Petra Stute, Ben Spycher, David Ginsbourger



Stepwise Prediction of Tuberculosis Treatment Outcomes Using XGBoost and Feature-Level Analysis: A Multi-Stage Approach to Clinical Decision Support

Linfeng Wang, Jody Phelan, Taane Clark



The use of variable selection in clinical prediction modelling for binary outcomes: a systematic review

Xinrui Su, Gareth Ambler, Nathan Green, Menelaos Pavlou



Comparison of Methods for Incorporating Related Data when Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen Martin, David Jenkins



A Systematic Review of Methodological Research on Multi-State Prediction Models

Chantelle Cornett, Glen Martin, Alexander Pate, Victoria Palin



Assessing the robustness of prediction models: A case study on in-hospital mortality prediction using MIMIC-III and MIMIC-IV

Alan Balendran, Raphaël Porcher



The Influence of Variable Selection Approaches on Prediction Model Stability in Low-Dimensional Data: From Traditional Stepwise Selection to Regularisation techniques

Noraworn Jirattikanwong, Phichayut Phinyo, Pakpoom Wongyikul, Natthanaphop Isaradech, Wachiranun Sirikul, Wuttipat Kiratipaisarl



Early-detection of high-risk patient profiles admitted to hospital with respiratory infections using a multistate model

João Pedro Carmezim, Cristian Tebé, Natàlia Pallarès, Roger Paredes, Cavan Reilly



Investigating fair data acquisition for risk prediction in resource-constrained settings

Ioanna Thoma, Matthew Sperrin, Karla Diaz Ordaz, Ricardo Silva, Brieuc Lehmann



A critical benchmark of Bayesian shrinkage estimation for subgroup analysis

Sebastian Weber, Björn Bornkamp, David Ohlssen



Mathematical Modelling of Oxygenation Dynamics Using High-Resolution Perfusion Data: An Advanced Statistical Framework for Understanding Oxygen Metabolism

Mansour Taghavi Azar Sharabiani, Alireza Mahani, Richard Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica



Marginal structural Cox model with weighted cumulative exposure modelling for the estimation of counterfactual Population Attributable Fractions

Yue Zhai, Ana-Maria Vilcu, Jacques Benichou, Lucas Morin, Agnès Fournier, Anne Thiébaut, Vivian Viallon



Lost in the Forest of Forest Plots? Practical Guidelines and an All-in-One Tool for Forest Plots

Hongqiu Gu, Yong Jiang, Hao Li



Robust Outlier Detection with Skewness-Adjusted Fences: Theoretical Foundations and Applications

YUNCHAE JUNG, MINSU PARK



Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles in Linear Regression: An Application to Estimating Shelf Life

Lingjiao Wang, Yang Han, Wei Liu, Frank Bretz



One-sided simultaneous tolerance intervals based on kernel density estimates

Gian Louisse Roy



Robust large-scale multiple testing for hidden Markov random field model

Donghwan Lee, Jiyn Sun



Model informed assurance approach for 3-way PK similarity studies

Rachid El Galta, Roland Baumgartner



Korea Sequence Read Archive (KRA) - A public repository for archiving raw sequence data

JAEHO LEE



Integrative analysis of transcriptomic and epigenomic dynamics of liver organoids using single cell RNA-seq and ATAC-seq

Kwang Hoon Cho, Jong-Hwan Kim, Jimin Kim, Jahyun Yun, Dayeon Kang



Leveraging tumor imaging compositional data structure in model feature space for predicting recurrence in colorectal carcinoma

Olivia J Bobek, Nicholas Larson, Rish K Pai, Fang-Shu Ou



BayesPIM: A Bayesian Prevalence-Incidence Mixture Model for Screening Outcomes, with an Application to Colorectal Cancer

Thomas Klausch, Birgit Lissenberg-Witte, Veerle Coupé



Joint Modelling of Random Heterogeneity in Longitudinal and Multiple time-to-Events in Colon Cancer

DIVYA DENNIS, Jagathnath Krishna KM



Refining the Association between BMI, Waist Circumference, and Breast Cancer Risk in Postmenopausal Women using G-formula Method

Somin Jeon, Boyoung Park, Junghyun Yoon



Building cancer risk prediction models by synthesizing national registry and prevention trial data

Oksana Chernova, Donna Ankerst, Ruth M Pfeiffer



Modelling Individual-level Uncertainty from Missing Data in Personalised Breast Cancer Risk Prediction

Bethan L. White, Lorenzo Ficorella, Xin Yang, Douglas F. Easton, Antonis C. Antoniou



Time-varying covariates in Survival Analysis: a graphical approach to assessing the risk of cardiovascular events and aortic valve sclerosis development

Arianna Galotta, Francesco Maria Mattio, Veronika Myasoedova, Elisabetta Salvioni, Paolo Poggio, Piergiuseppe Agostoni, Alice Bonomi



Polygenic scores as tools for intervention selection in the setting of finasteride for prostate cancer prevention

Allison Meisner



Implementation of a Disease Progression Model accounting for covariates

Gabrielle Casimiro, Sofia Kaisaridi, Sophie Tezenas du Montcel



Genetics influences LDL-C response to statin therapy: short- and long-term observational study with functional data analysis

Andrea Corbetta, Emanuele Di Angelantonio, Andrea Ganna, Francesca Ieva



Longitudinal analysis of imprecise disease status using latent Markov models: application to Italian Thyroid Cancer Observatory data

Silvia D'Elia, Marco Alfò, Maria Francesca Marino



Long-term risk prediction from short-term data – a microsimulation approach

Moritz Pamminger, Theresa Ullmann, Moritz Madern, Daniela Dunkler, Georg Heinze



Deep learning algorithm for dynamic survival prediction with competitive risks

Tristan Margaté, Marine Zulian, Agathe Guilloux, Sandrine Katsahian



Identifying Cutoff in Predictors in Survival Analysis: An Ensemble Strategy for Flexible Knot Selection

Stefania Lando, Giulia Lorenzoni, Dario Gregori



Estimating Quality Adjusted Life Years (QALYs) from a joint modeling framework: a simulation-based study

Vincent Bonnemains, Yohann Foucher, Philippe Tessier, Etienne Dantan



An Alternative Estimand for Overall Survival in the Presence of Treatment Discontinuation: Simulation Results and Case Study

Kara-Louise Royle, David Meads, Jennifer Visser-Rogers, David A Cairns, Ian R White



Corrections of confidence interval for differences in restricted mean survival times in clinical trials with small sample sizes

Hiroya Hashimoto, Akiko Kada



Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry

Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson



Development and validation of prognostic models in phase I oncology clinical trials

Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr



Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint

Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva



Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors

Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux



Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration

Luca Genetti, Andrea Nizzardo, Marco Pergher



Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials

XINGZHI XU, SATOSHI HATTORI



Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints

Go Horiguchi, Isao Yokota, Satoshi Teramukai



Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes

Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap



Estimands in platform trials with time - treatment interactions

ZIYAN WANG, Dave Woods



A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design

Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess



Optimizing Biomarker-Based Enrichment strategies in clinical trials

Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun



Leveraging Synthetic Data for Enhanced Clinical Research Outcomes

Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska



Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL

Byoung Ha Yoon



Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM

Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk



Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models

ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI



Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand

Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian



Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol

Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme



Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards.

Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson



Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models

Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott



Automating Report Generation with Stata: A Case Study of NORUSE

Maria Elstad



Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis.

MOHAMMED ABDU MUDAWI



Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis

Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner



Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes

Mahru Ahmad, Jack Wilkinson, Andy Vail



Causal discovery for multi-cohort studies

Christine Bang, Vanessa Didelez



Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms

A F M Tahsin Shahriar, AHM Mahbub-ul Latif



Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods

Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao



Revisiting subgroup analysis: A reflection on health disparities using conditional independence

Nia Kang, Tibor Schuster



Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study

Jingya Zhao, Gareth Ambler, Baptiste Leurent



Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods.

Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden



Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome

Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz



Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis

Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka



Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative

Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier



Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol

Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango



Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates

Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume



Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial.

Robin Young, Alex McConnachie, Helen Minnis



The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation

Gregory Chen, Micahel Seo, Isaac Gravestock



Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials

Patrick Djidel, Armand Chouzy, Pierre Colin



Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance

Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock



Power calculation using the win-ratio for composite outcomes in randomized trials

David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held



Feasibility of propensity score weighted analysis in rare disease trials: a simulation study

Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini



A basket trial for rare diseases, with a crossover design for its substudies: a simulation study

Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout



Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias

Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets



Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials

Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng



Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials

Anjali Yadav

9:15am
-
10:45am
Mathematical and Statistical Modelling in the Life Sciences: Seeking causal explanations
Location: Biozentrum U1.111
 

In silico simulations of cancer-immune interactions to aid clinical trial design and execution

Johannes Textor, Jeroen Creemers



Evolutionary dynamics of cancer progression and response to treatment

Ivana Bozic



Using DAGs and dynamical simulations to explore and understand causal links

Theis Lange

Clinical trials with longitudinal and clustered data
Location: Biozentrum U1.131
 

Location-Scale Latent Process Model for Repeated Ordinal Patient Reported Outcomes

Agnieszka Król, Robert Palmér, Jacob Leander, Cécile Proust-Lima, Alexandra Jauhiainen



Causal approaches for the design and long-term treatment effect estimations of hybrid randomized clinical trials with longitudinal outcomes

Xiner Zhou, Herbert Pang, Christiana Drake, Hans Ulrich Burger, Jiawen Zhu



Prediction powered inference for trials with survival outcomes

Maylis Tran, Pierre-Emmanuel Poulet, Bruno Jedynak, Sophie Tezenas du Montcel



Repeated measurements modelling of titration effects in multi-arm clinical trials

Emma Ove Dahl, Philip Hougaard

Bayesian methods 2
Location: Biozentrum U1.141
 

Using a foundation model for detecting and reducing site-specific differences in federated meta-analysis of regression models

Patric Tippmann, Max Behrens, Harald Binder



Sample size calculations for prediction model development: A general Bayesian-framework using posterior distributions to examine expected performance, degradation and stability

Richard D Riley, Rebecca Whittle, Mohsen Sadatsafavi, Glen Martin, Alexander Pate, Gary Collins, Joie Ensor



Efficient Utilization of Dose-Schedule Grids for Optimal Therapeutic Outcomes in Non-Oncology Settings

Lars Andersen, Mitchell Thomann, Thomas Jaki



On the interplay between prior weight and vague variance in Robust Mixture Priors

Marco Ratta, Gaëlle Saint-Hilary, Pavel Mozgunov



Bayesian nonparametric methods for inferring causal effects of longitudinal treatments amidst missing covariate data

Liangyuan Hu

Machine learning 1
Location: Biozentrum U1.101
 

Causal machine learning methods for dynamic and static treatment strategies deprescribing medications in a polypharmacy population using electronic health records.

Maurice M O'Connell, Michael Abaho, Aseel S Abuzour, Matin Ahmed, Saiqa Ahmed, Asra Aslam, Danushka Bollegala, Iain Buchan, Harriet Cant, Andrew Clegg, Mark Gabbay, Alan Griffiths, Layik Hama, Francine Jury, Gary Leeming, Emma Lo, Frances S Mair, Simon Maskell, Erin McCloskey, Olusegun Popoola, Samuel Relton, Roy A Ruddle, Pieta Schofield, Eduard Shantsila, Tjeerd Van Staa, Lauren E Walker, Samantha A Wilson, Alan A Woodall, Rachael Wright, Matthew Sperrin



Overview and practical recommendations on using Shapley Values for identifying predictive biomarkers via CATE modeling

David Svensson, Erik Hermansson, Konstantinos Sechidis, Nikos Nikolaou, Ilya Lipkovich



Signpost testing to navigate the high-dimensional parameter space of the linear regression model

Wessel van Wieringen



Leveraging Influence Functions for Statistical Inference in R

Klaus Holst



Optimal testing for the presence of conditional average treatment effects

Feng Liang, Kelly Van Lancker, Stijn Vansteelandt

Infectious disease modelling
Location: ETH E27
 

Flexible parametric additive hazards regression for modeling excess mortality in pandemics

Liesbeth C de Wreede, Marina T Dietrich, Ilaria Prosepe, Hein Putter, Mar Rodriguez-Girondo



Parameter Estimation in Compartmental Epidemic Models with Heterogeneity in Susceptibility

Yuwen Ding, Jacco Wallinga, Hein Putter



Unobserved intermediate events in multi-state models in a pandemic setting

Ilaria Prosepe, Hein Putter, Mar Rodriguez-Girondo, Liesbeth C. de Wreede



Controlled vaccine efficacy using a joint model for sparse immunological data and time-to-disease.

Grigorios Papageorgiou, Silvia Noirjean, Toufik Zahaf, Andrea Callegaro



Infectious Disease Estimands That Are Insensitive to Interference

Mats Stensrud

Meta science 1
Location: ETH E23
 

Quantifying the variation in effects due to multiplicity of analysis strategies – A conceptional perspective

Susanne Strohmaier, S.Necdet Cervirme, Georg Heinze, Michael Kammer, Moritz Pamminger, Daniela Dunkler



Uncertainty in individual predictions: sample size versus model and modeler choices

Toby Hackmann, Ben van Calster, Liesbeth C de Wreede, Ewout W Steyerberg



Quantifying reproducibility - Results from a scoping review on reproducibility metrics and simulation studies into their real-world applicability

Rachel Heyard, Samuel Pawel, Joris Frese, Bernhard Voelkl, Hanno Würbel, Sarah K McCann, Kimberley E Wever, Helena Hartmann, Louise Townsin, Stephanie Zellers, Leonhard Held



Data quality, a blind spot in study and reporting guidelines

Carsten Oliver Schmidt



To adjust or not: it is not the tests performed that count but how they are reported and interpreted

Sabine Hoffmann, Simon Lemster, Juliane Wilcke, Anne-Laure Boulesteix

Design and analysis of trials in rare diseases
Location: ETH E21
 

Blinded sample size re-estimation accounting for estimation error with small internal pilot studies

Hirotada Maeda, Satoshi Hattori, Tim Friede



Randomization in clinical trials with small sample sizes using group sequential designs

Daniel Bodden, Ralf-Dieter Hilgers, Franz König



Adjusting for allocation bias in stratified clinical trials with multi-component endpoints

Stefanie Schoenen, Ralf-Dieter Hilgers, Nicole Heussen



Methodological insights from the EPISTOP trial for designing and analysing clinical trials in rare diseases

Stephanie Wied, Ralf-Dieter Hilgers



Modified crossover trials to improve feasibility of evaluating multiple treatments for rare relapsing-remitting conditions

James Wason

Poster Exhibition: T / Tuesday posters
Location: Poster Location
 

Leveraging Wearable data for Probabilistic Imputation in Cardiovascular Risk Calculators.

Antoine Faul, Patric Wyss, Anja Mühlemann, Manuela Moraru, Danielle Bower, Petra Stute, Ben Spycher, David Ginsbourger



Stepwise Prediction of Tuberculosis Treatment Outcomes Using XGBoost and Feature-Level Analysis: A Multi-Stage Approach to Clinical Decision Support

Linfeng Wang, Jody Phelan, Taane Clark



The use of variable selection in clinical prediction modelling for binary outcomes: a systematic review

Xinrui Su, Gareth Ambler, Nathan Green, Menelaos Pavlou



Comparison of Methods for Incorporating Related Data when Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen Martin, David Jenkins



A Systematic Review of Methodological Research on Multi-State Prediction Models

Chantelle Cornett, Glen Martin, Alexander Pate, Victoria Palin



Assessing the robustness of prediction models: A case study on in-hospital mortality prediction using MIMIC-III and MIMIC-IV

Alan Balendran, Raphaël Porcher



The Influence of Variable Selection Approaches on Prediction Model Stability in Low-Dimensional Data: From Traditional Stepwise Selection to Regularisation techniques

Noraworn Jirattikanwong, Phichayut Phinyo, Pakpoom Wongyikul, Natthanaphop Isaradech, Wachiranun Sirikul, Wuttipat Kiratipaisarl



Early-detection of high-risk patient profiles admitted to hospital with respiratory infections using a multistate model

João Pedro Carmezim, Cristian Tebé, Natàlia Pallarès, Roger Paredes, Cavan Reilly



Investigating fair data acquisition for risk prediction in resource-constrained settings

Ioanna Thoma, Matthew Sperrin, Karla Diaz Ordaz, Ricardo Silva, Brieuc Lehmann



A critical benchmark of Bayesian shrinkage estimation for subgroup analysis

Sebastian Weber, Björn Bornkamp, David Ohlssen



Mathematical Modelling of Oxygenation Dynamics Using High-Resolution Perfusion Data: An Advanced Statistical Framework for Understanding Oxygen Metabolism

Mansour Taghavi Azar Sharabiani, Alireza Mahani, Richard Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica



Marginal structural Cox model with weighted cumulative exposure modelling for the estimation of counterfactual Population Attributable Fractions

Yue Zhai, Ana-Maria Vilcu, Jacques Benichou, Lucas Morin, Agnès Fournier, Anne Thiébaut, Vivian Viallon



Lost in the Forest of Forest Plots? Practical Guidelines and an All-in-One Tool for Forest Plots

Hongqiu Gu, Yong Jiang, Hao Li



Robust Outlier Detection with Skewness-Adjusted Fences: Theoretical Foundations and Applications

YUNCHAE JUNG, MINSU PARK



Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles in Linear Regression: An Application to Estimating Shelf Life

Lingjiao Wang, Yang Han, Wei Liu, Frank Bretz



One-sided simultaneous tolerance intervals based on kernel density estimates

Gian Louisse Roy



Robust large-scale multiple testing for hidden Markov random field model

Donghwan Lee, Jiyn Sun



Model informed assurance approach for 3-way PK similarity studies

Rachid El Galta, Roland Baumgartner



Korea Sequence Read Archive (KRA) - A public repository for archiving raw sequence data

JAEHO LEE



Integrative analysis of transcriptomic and epigenomic dynamics of liver organoids using single cell RNA-seq and ATAC-seq

Kwang Hoon Cho, Jong-Hwan Kim, Jimin Kim, Jahyun Yun, Dayeon Kang



Leveraging tumor imaging compositional data structure in model feature space for predicting recurrence in colorectal carcinoma

Olivia J Bobek, Nicholas Larson, Rish K Pai, Fang-Shu Ou



BayesPIM: A Bayesian Prevalence-Incidence Mixture Model for Screening Outcomes, with an Application to Colorectal Cancer

Thomas Klausch, Birgit Lissenberg-Witte, Veerle Coupé



Joint Modelling of Random Heterogeneity in Longitudinal and Multiple time-to-Events in Colon Cancer

DIVYA DENNIS, Jagathnath Krishna KM



Refining the Association between BMI, Waist Circumference, and Breast Cancer Risk in Postmenopausal Women using G-formula Method

Somin Jeon, Boyoung Park, Junghyun Yoon



Building cancer risk prediction models by synthesizing national registry and prevention trial data

Oksana Chernova, Donna Ankerst, Ruth M Pfeiffer



Modelling Individual-level Uncertainty from Missing Data in Personalised Breast Cancer Risk Prediction

Bethan L. White, Lorenzo Ficorella, Xin Yang, Douglas F. Easton, Antonis C. Antoniou



Time-varying covariates in Survival Analysis: a graphical approach to assessing the risk of cardiovascular events and aortic valve sclerosis development

Arianna Galotta, Francesco Maria Mattio, Veronika Myasoedova, Elisabetta Salvioni, Paolo Poggio, Piergiuseppe Agostoni, Alice Bonomi



Polygenic scores as tools for intervention selection in the setting of finasteride for prostate cancer prevention

Allison Meisner



Implementation of a Disease Progression Model accounting for covariates

Gabrielle Casimiro, Sofia Kaisaridi, Sophie Tezenas du Montcel



Genetics influences LDL-C response to statin therapy: short- and long-term observational study with functional data analysis

Andrea Corbetta, Emanuele Di Angelantonio, Andrea Ganna, Francesca Ieva



Longitudinal analysis of imprecise disease status using latent Markov models: application to Italian Thyroid Cancer Observatory data

Silvia D'Elia, Marco Alfò, Maria Francesca Marino



Long-term risk prediction from short-term data – a microsimulation approach

Moritz Pamminger, Theresa Ullmann, Moritz Madern, Daniela Dunkler, Georg Heinze



Deep learning algorithm for dynamic survival prediction with competitive risks

Tristan Margaté, Marine Zulian, Agathe Guilloux, Sandrine Katsahian



Identifying Cutoff in Predictors in Survival Analysis: An Ensemble Strategy for Flexible Knot Selection

Stefania Lando, Giulia Lorenzoni, Dario Gregori



Estimating Quality Adjusted Life Years (QALYs) from a joint modeling framework: a simulation-based study

Vincent Bonnemains, Yohann Foucher, Philippe Tessier, Etienne Dantan



An Alternative Estimand for Overall Survival in the Presence of Treatment Discontinuation: Simulation Results and Case Study

Kara-Louise Royle, David Meads, Jennifer Visser-Rogers, David A Cairns, Ian R White



Corrections of confidence interval for differences in restricted mean survival times in clinical trials with small sample sizes

Hiroya Hashimoto, Akiko Kada



Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry

Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson



Development and validation of prognostic models in phase I oncology clinical trials

Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr



Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint

Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva



Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors

Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux



Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration

Luca Genetti, Andrea Nizzardo, Marco Pergher



Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials

XINGZHI XU, SATOSHI HATTORI



Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints

Go Horiguchi, Isao Yokota, Satoshi Teramukai



Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes

Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap



Estimands in platform trials with time - treatment interactions

ZIYAN WANG, Dave Woods



A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design

Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess



Optimizing Biomarker-Based Enrichment strategies in clinical trials

Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun



Leveraging Synthetic Data for Enhanced Clinical Research Outcomes

Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska



Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL

Byoung Ha Yoon



Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM

Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk



Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models

ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI



Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand

Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian



Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol

Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme



Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards.

Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson



Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models

Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott



Automating Report Generation with Stata: A Case Study of NORUSE

Maria Elstad



Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis.

MOHAMMED ABDU MUDAWI



Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis

Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner



Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes

Mahru Ahmad, Jack Wilkinson, Andy Vail



Causal discovery for multi-cohort studies

Christine Bang, Vanessa Didelez



Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms

A F M Tahsin Shahriar, AHM Mahbub-ul Latif



Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods

Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao



Revisiting subgroup analysis: A reflection on health disparities using conditional independence

Nia Kang, Tibor Schuster



Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study

Jingya Zhao, Gareth Ambler, Baptiste Leurent



Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods.

Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden



Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome

Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz



Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis

Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka



Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative

Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier



Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol

Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango



Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates

Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume



Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial.

Robin Young, Alex McConnachie, Helen Minnis



The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation

Gregory Chen, Micahel Seo, Isaac Gravestock



Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials

Patrick Djidel, Armand Chouzy, Pierre Colin



Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance

Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock



Power calculation using the win-ratio for composite outcomes in randomized trials

David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held



Feasibility of propensity score weighted analysis in rare disease trials: a simulation study

Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini



A basket trial for rare diseases, with a crossover design for its substudies: a simulation study

Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout



Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias

Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets



Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials

Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng



Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials

Anjali Yadav

10:45am
-
11:30am
Coffee Break
Poster Exhibition: T / Tuesday posters
Location: Poster Location
 

Leveraging Wearable data for Probabilistic Imputation in Cardiovascular Risk Calculators.

Antoine Faul, Patric Wyss, Anja Mühlemann, Manuela Moraru, Danielle Bower, Petra Stute, Ben Spycher, David Ginsbourger



Stepwise Prediction of Tuberculosis Treatment Outcomes Using XGBoost and Feature-Level Analysis: A Multi-Stage Approach to Clinical Decision Support

Linfeng Wang, Jody Phelan, Taane Clark



The use of variable selection in clinical prediction modelling for binary outcomes: a systematic review

Xinrui Su, Gareth Ambler, Nathan Green, Menelaos Pavlou



Comparison of Methods for Incorporating Related Data when Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen Martin, David Jenkins



A Systematic Review of Methodological Research on Multi-State Prediction Models

Chantelle Cornett, Glen Martin, Alexander Pate, Victoria Palin



Assessing the robustness of prediction models: A case study on in-hospital mortality prediction using MIMIC-III and MIMIC-IV

Alan Balendran, Raphaël Porcher



The Influence of Variable Selection Approaches on Prediction Model Stability in Low-Dimensional Data: From Traditional Stepwise Selection to Regularisation techniques

Noraworn Jirattikanwong, Phichayut Phinyo, Pakpoom Wongyikul, Natthanaphop Isaradech, Wachiranun Sirikul, Wuttipat Kiratipaisarl



Early-detection of high-risk patient profiles admitted to hospital with respiratory infections using a multistate model

João Pedro Carmezim, Cristian Tebé, Natàlia Pallarès, Roger Paredes, Cavan Reilly



Investigating fair data acquisition for risk prediction in resource-constrained settings

Ioanna Thoma, Matthew Sperrin, Karla Diaz Ordaz, Ricardo Silva, Brieuc Lehmann



A critical benchmark of Bayesian shrinkage estimation for subgroup analysis

Sebastian Weber, Björn Bornkamp, David Ohlssen



Mathematical Modelling of Oxygenation Dynamics Using High-Resolution Perfusion Data: An Advanced Statistical Framework for Understanding Oxygen Metabolism

Mansour Taghavi Azar Sharabiani, Alireza Mahani, Richard Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica



Marginal structural Cox model with weighted cumulative exposure modelling for the estimation of counterfactual Population Attributable Fractions

Yue Zhai, Ana-Maria Vilcu, Jacques Benichou, Lucas Morin, Agnès Fournier, Anne Thiébaut, Vivian Viallon



Lost in the Forest of Forest Plots? Practical Guidelines and an All-in-One Tool for Forest Plots

Hongqiu Gu, Yong Jiang, Hao Li



Robust Outlier Detection with Skewness-Adjusted Fences: Theoretical Foundations and Applications

YUNCHAE JUNG, MINSU PARK



Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles in Linear Regression: An Application to Estimating Shelf Life

Lingjiao Wang, Yang Han, Wei Liu, Frank Bretz



One-sided simultaneous tolerance intervals based on kernel density estimates

Gian Louisse Roy



Robust large-scale multiple testing for hidden Markov random field model

Donghwan Lee, Jiyn Sun



Model informed assurance approach for 3-way PK similarity studies

Rachid El Galta, Roland Baumgartner



Korea Sequence Read Archive (KRA) - A public repository for archiving raw sequence data

JAEHO LEE



Integrative analysis of transcriptomic and epigenomic dynamics of liver organoids using single cell RNA-seq and ATAC-seq

Kwang Hoon Cho, Jong-Hwan Kim, Jimin Kim, Jahyun Yun, Dayeon Kang



Leveraging tumor imaging compositional data structure in model feature space for predicting recurrence in colorectal carcinoma

Olivia J Bobek, Nicholas Larson, Rish K Pai, Fang-Shu Ou



BayesPIM: A Bayesian Prevalence-Incidence Mixture Model for Screening Outcomes, with an Application to Colorectal Cancer

Thomas Klausch, Birgit Lissenberg-Witte, Veerle Coupé



Joint Modelling of Random Heterogeneity in Longitudinal and Multiple time-to-Events in Colon Cancer

DIVYA DENNIS, Jagathnath Krishna KM



Refining the Association between BMI, Waist Circumference, and Breast Cancer Risk in Postmenopausal Women using G-formula Method

Somin Jeon, Boyoung Park, Junghyun Yoon



Building cancer risk prediction models by synthesizing national registry and prevention trial data

Oksana Chernova, Donna Ankerst, Ruth M Pfeiffer



Modelling Individual-level Uncertainty from Missing Data in Personalised Breast Cancer Risk Prediction

Bethan L. White, Lorenzo Ficorella, Xin Yang, Douglas F. Easton, Antonis C. Antoniou



Time-varying covariates in Survival Analysis: a graphical approach to assessing the risk of cardiovascular events and aortic valve sclerosis development

Arianna Galotta, Francesco Maria Mattio, Veronika Myasoedova, Elisabetta Salvioni, Paolo Poggio, Piergiuseppe Agostoni, Alice Bonomi



Polygenic scores as tools for intervention selection in the setting of finasteride for prostate cancer prevention

Allison Meisner



Implementation of a Disease Progression Model accounting for covariates

Gabrielle Casimiro, Sofia Kaisaridi, Sophie Tezenas du Montcel



Genetics influences LDL-C response to statin therapy: short- and long-term observational study with functional data analysis

Andrea Corbetta, Emanuele Di Angelantonio, Andrea Ganna, Francesca Ieva



Longitudinal analysis of imprecise disease status using latent Markov models: application to Italian Thyroid Cancer Observatory data

Silvia D'Elia, Marco Alfò, Maria Francesca Marino



Long-term risk prediction from short-term data – a microsimulation approach

Moritz Pamminger, Theresa Ullmann, Moritz Madern, Daniela Dunkler, Georg Heinze



Deep learning algorithm for dynamic survival prediction with competitive risks

Tristan Margaté, Marine Zulian, Agathe Guilloux, Sandrine Katsahian



Identifying Cutoff in Predictors in Survival Analysis: An Ensemble Strategy for Flexible Knot Selection

Stefania Lando, Giulia Lorenzoni, Dario Gregori



Estimating Quality Adjusted Life Years (QALYs) from a joint modeling framework: a simulation-based study

Vincent Bonnemains, Yohann Foucher, Philippe Tessier, Etienne Dantan



An Alternative Estimand for Overall Survival in the Presence of Treatment Discontinuation: Simulation Results and Case Study

Kara-Louise Royle, David Meads, Jennifer Visser-Rogers, David A Cairns, Ian R White



Corrections of confidence interval for differences in restricted mean survival times in clinical trials with small sample sizes

Hiroya Hashimoto, Akiko Kada



Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry

Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson



Development and validation of prognostic models in phase I oncology clinical trials

Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr



Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint

Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva



Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors

Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux



Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration

Luca Genetti, Andrea Nizzardo, Marco Pergher



Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials

XINGZHI XU, SATOSHI HATTORI



Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints

Go Horiguchi, Isao Yokota, Satoshi Teramukai



Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes

Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap



Estimands in platform trials with time - treatment interactions

ZIYAN WANG, Dave Woods



A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design

Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess



Optimizing Biomarker-Based Enrichment strategies in clinical trials

Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun



Leveraging Synthetic Data for Enhanced Clinical Research Outcomes

Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska



Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL

Byoung Ha Yoon



Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM

Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk



Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models

ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI



Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand

Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian



Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol

Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme



Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards.

Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson



Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models

Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott



Automating Report Generation with Stata: A Case Study of NORUSE

Maria Elstad



Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis.

MOHAMMED ABDU MUDAWI



Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis

Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner



Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes

Mahru Ahmad, Jack Wilkinson, Andy Vail



Causal discovery for multi-cohort studies

Christine Bang, Vanessa Didelez



Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms

A F M Tahsin Shahriar, AHM Mahbub-ul Latif



Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods

Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao



Revisiting subgroup analysis: A reflection on health disparities using conditional independence

Nia Kang, Tibor Schuster



Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study

Jingya Zhao, Gareth Ambler, Baptiste Leurent



Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods.

Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden



Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome

Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz



Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis

Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka



Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative

Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier



Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol

Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango



Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates

Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume



Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial.

Robin Young, Alex McConnachie, Helen Minnis



The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation

Gregory Chen, Micahel Seo, Isaac Gravestock



Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials

Patrick Djidel, Armand Chouzy, Pierre Colin



Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance

Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock



Power calculation using the win-ratio for composite outcomes in randomized trials

David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held



Feasibility of propensity score weighted analysis in rare disease trials: a simulation study

Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini



A basket trial for rare diseases, with a crossover design for its substudies: a simulation study

Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout



Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias

Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets



Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials

Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng



Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials

Anjali Yadav

11:30am
-
1:00pm
Optimizing efficiency in adaptive trial designs
Location: Biozentrum U1.111
 

Title TBD

Frank Petavy



Optimizing Treatment Allocation in Platform Trials: A Need for New Rules?

Marta Bofill Roig, Martin Posch



Confirmatory adaptive enrichment designs with a continuous biomarker

Nigel Stallard

Survival and recurrent events in clinical trials
Location: Biozentrum U1.131
 

Reevaluating Recurrent Events in Heart Failure Trials: Patterns, Prognostic Implications, and Analytical Improvements

Audinga-Dea Hazewinkel, John Gregson, Stuart J Pocock, John McMurray, Scott D Solomon, Brian Claggett, Milton Packer, Stefan D Anker, João P Ferreira, Kieran Docherty, Alasdair Henderson, Pardeep Jhund, Ulrica Wilderäng, David Wright



Balancing events, not patients, maximizes power of the logrank test: and other insights on unequal randomization in survival trials

Godwin Yung, Kaspar Rufibach, Marcel Wolbers, Ray Lin, Yi Liu



An alternative to classical intention-to-treat analysis for comparing a time-to-event endpoint in precision oncology trials

Marilena Müller



Proposing a new method to estimate the survival of the Intention-to-Treat population in trials with Two-Stage-Randomization-Design

Dan Huang, Eva Hoster, Stefan Englert, Martin Dreyling, Ulrich Mansmann



RCT for recurrent events

Thomas Scheike

Alternative estimands in causal inference
Location: Biozentrum U1.141
 

Assumption-lean modeling for patient-centered decision-making

Stijn Vansteelandt, Georgi Baklicharov



Causal inference targeting a concentration index for studies of health inequalities

Mohammad Ghasempour, Xavier de Luna, Per Gustafsson



Rethinking the Win Ratio: A Causal Framework for Hierarchical Outcome Analysis

Julie Josse, Mathieu Even



Assessing individual-level uncertainty of causal predictions through the causal effective sample size

Doranne Thomassen, Daniala Weir, Marleen Kunneman, Nan van Geloven



Estimating Win Ratio for Prioritized Composite Outcomes in the Presence of Noncompliance

Md. Muhitul Alam, Mahbub A.H.M. Latif, M. Iftakhar Alam, Abdus S Wahed

Machine learning, deep learning, and AI
Location: Biozentrum U1.101
 

Performance evaluation of dimensionality reduction techniques on high-dimensional DNA methylation data

Kuldeep Kumar Sharma, Binukumar B, Binu V. S, Thirumoorthy Chinnasamy, Gokulakrishnan K, Saravanan P, Mohan V



Deep Generalised Mixed Effects Models: a Novel General Neural Network Structure for Analysing Hierarchical Data

Nina van Gerwen, Dimitris Rizopoulos, Manon Hillegers, Loes Keijsers, Sten Willemsen



Adapting transformer neural networks for longitudinal data with few time points

Kiana Farhadyar, Harald Binder



Distinguishing subgroup and site-specific heterogeneity in multi-site prognostic models using a neural network representation

Max Behrens, Daiana Stolz, Eleni Papakonstantinou, Janis M. Nolde, Gabriele Bellerino, Moritz Hess, Harald Binder



Unraveling Breast Cancer Genetic Risk in Chinese Women: Integrating GWAS, Fine-Mapping, and Machine Learning in the China Kadoorie Biobank

Shizhe Xu, Christiana Kartsonaki, Kuang Lin, Kyriaki Michailidou

Meta-analysis 2
Location: ETH E27
 

How to quantify between-study heterogeneity in single-arm evidence synthesis

Ulrike Held, Lea Bührer, Beatrix Latal, Stefania Iaquinto



Bayesian random-effects meta-analysis with empirical heterogeneity priors for HTA applications in the situation of very few studies

Ralf Bender, Jona Lilienthal, Sibylle Sturtz, Christian Röver, Tim Friede



Assessing inconsistency in flexible meta-regression using network meta analysis

Marc Angelo Parsons, Andrea Benedetti, Russell Steele



Illuminating the Assumptions of Meta-Regression in Treatment Networks

Nana-adjoa Kwarteng, Theodoros Evrenoglou, Adriani Nikolakopoulou



Transitivity in Network Meta-Analysis: A Formal Framework and Practical Implications

Noosheen Rajabzadeh Tahmasebi, Ian White, Georgia Salanti, Efthimiou Orestis, Adriani Nikolakopoulou

Meta science 2
Location: ETH E23
 

Developing communication skills in biostatistical consulting and collaboration

Karen Lamb, Sabine Braat, Julie Simpson



Are we “Essential” or “Not Needed”? Varying perceptions of statisticians' value, a national study of human research ethics committees

Adrian Barnett, Nicole White, Taya A Collyer



An Empirical Assessment of the Cost of Dichotomization

Erik van Zwet, Frank Harrell, Stephen Senn



Reporting Completeness in Conventional and Machine Learning-Based COVID-19 Prognostic Models: A Meta-Epidemiological Study

Ioannis Partheniadis, Persefoni Talimtzi, Adriani Nikolakopoulou, Anna Haidich



How to improve data quality reporting: a real-world data example using registry data

Elena Salogni, Thomas J. Musholt, Elisa Kasbohm, Stephan Struckmann, Carsten Oliver Schmidt

Statistical methods in epidemiology
Location: ETH E21
 

Federated Inference methods for estimation and comparison of Standardized Mortality Ratios

Zoë D. van den Heuvel, Bas de Groot, Marianne A. Jonker



A mixture model for subtype identification: Application to CADASIL

Sofia Kaisaridi, Juliette Ortholand, Caglayan Tuna, Nicolas Gensollen, Sophie Tezenas du Montcel



Performance of a residual-based algorithm aiming at identifying response shift at the item level using Rasch models: a simulation study

Yseulys Dubuy, Victor Rechard, Véronique Sébille



Lifecourse modelling and time-varying covariates: empirical application and simulation study for novel method

Solomon Beer, Sherief Eldeeb, Erin Dunn, Andrew Simpkin, Andrew Smith



Emulating hypothetical interventions of physical activity on obesity: applying target trial emulation in the 1970 Birth Cohort Study

Michail Katsoulis, Jamie Wong

Poster Exhibition: T / Tuesday posters
Location: Poster Location
 

Leveraging Wearable data for Probabilistic Imputation in Cardiovascular Risk Calculators.

Antoine Faul, Patric Wyss, Anja Mühlemann, Manuela Moraru, Danielle Bower, Petra Stute, Ben Spycher, David Ginsbourger



Stepwise Prediction of Tuberculosis Treatment Outcomes Using XGBoost and Feature-Level Analysis: A Multi-Stage Approach to Clinical Decision Support

Linfeng Wang, Jody Phelan, Taane Clark



The use of variable selection in clinical prediction modelling for binary outcomes: a systematic review

Xinrui Su, Gareth Ambler, Nathan Green, Menelaos Pavlou



Comparison of Methods for Incorporating Related Data when Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen Martin, David Jenkins



A Systematic Review of Methodological Research on Multi-State Prediction Models

Chantelle Cornett, Glen Martin, Alexander Pate, Victoria Palin



Assessing the robustness of prediction models: A case study on in-hospital mortality prediction using MIMIC-III and MIMIC-IV

Alan Balendran, Raphaël Porcher



The Influence of Variable Selection Approaches on Prediction Model Stability in Low-Dimensional Data: From Traditional Stepwise Selection to Regularisation techniques

Noraworn Jirattikanwong, Phichayut Phinyo, Pakpoom Wongyikul, Natthanaphop Isaradech, Wachiranun Sirikul, Wuttipat Kiratipaisarl



Early-detection of high-risk patient profiles admitted to hospital with respiratory infections using a multistate model

João Pedro Carmezim, Cristian Tebé, Natàlia Pallarès, Roger Paredes, Cavan Reilly



Investigating fair data acquisition for risk prediction in resource-constrained settings

Ioanna Thoma, Matthew Sperrin, Karla Diaz Ordaz, Ricardo Silva, Brieuc Lehmann



A critical benchmark of Bayesian shrinkage estimation for subgroup analysis

Sebastian Weber, Björn Bornkamp, David Ohlssen



Mathematical Modelling of Oxygenation Dynamics Using High-Resolution Perfusion Data: An Advanced Statistical Framework for Understanding Oxygen Metabolism

Mansour Taghavi Azar Sharabiani, Alireza Mahani, Richard Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica



Marginal structural Cox model with weighted cumulative exposure modelling for the estimation of counterfactual Population Attributable Fractions

Yue Zhai, Ana-Maria Vilcu, Jacques Benichou, Lucas Morin, Agnès Fournier, Anne Thiébaut, Vivian Viallon



Lost in the Forest of Forest Plots? Practical Guidelines and an All-in-One Tool for Forest Plots

Hongqiu Gu, Yong Jiang, Hao Li



Robust Outlier Detection with Skewness-Adjusted Fences: Theoretical Foundations and Applications

YUNCHAE JUNG, MINSU PARK



Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles in Linear Regression: An Application to Estimating Shelf Life

Lingjiao Wang, Yang Han, Wei Liu, Frank Bretz



One-sided simultaneous tolerance intervals based on kernel density estimates

Gian Louisse Roy



Robust large-scale multiple testing for hidden Markov random field model

Donghwan Lee, Jiyn Sun



Model informed assurance approach for 3-way PK similarity studies

Rachid El Galta, Roland Baumgartner



Korea Sequence Read Archive (KRA) - A public repository for archiving raw sequence data

JAEHO LEE



Integrative analysis of transcriptomic and epigenomic dynamics of liver organoids using single cell RNA-seq and ATAC-seq

Kwang Hoon Cho, Jong-Hwan Kim, Jimin Kim, Jahyun Yun, Dayeon Kang



Leveraging tumor imaging compositional data structure in model feature space for predicting recurrence in colorectal carcinoma

Olivia J Bobek, Nicholas Larson, Rish K Pai, Fang-Shu Ou



BayesPIM: A Bayesian Prevalence-Incidence Mixture Model for Screening Outcomes, with an Application to Colorectal Cancer

Thomas Klausch, Birgit Lissenberg-Witte, Veerle Coupé



Joint Modelling of Random Heterogeneity in Longitudinal and Multiple time-to-Events in Colon Cancer

DIVYA DENNIS, Jagathnath Krishna KM



Refining the Association between BMI, Waist Circumference, and Breast Cancer Risk in Postmenopausal Women using G-formula Method

Somin Jeon, Boyoung Park, Junghyun Yoon



Building cancer risk prediction models by synthesizing national registry and prevention trial data

Oksana Chernova, Donna Ankerst, Ruth M Pfeiffer



Modelling Individual-level Uncertainty from Missing Data in Personalised Breast Cancer Risk Prediction

Bethan L. White, Lorenzo Ficorella, Xin Yang, Douglas F. Easton, Antonis C. Antoniou



Time-varying covariates in Survival Analysis: a graphical approach to assessing the risk of cardiovascular events and aortic valve sclerosis development

Arianna Galotta, Francesco Maria Mattio, Veronika Myasoedova, Elisabetta Salvioni, Paolo Poggio, Piergiuseppe Agostoni, Alice Bonomi



Polygenic scores as tools for intervention selection in the setting of finasteride for prostate cancer prevention

Allison Meisner



Implementation of a Disease Progression Model accounting for covariates

Gabrielle Casimiro, Sofia Kaisaridi, Sophie Tezenas du Montcel



Genetics influences LDL-C response to statin therapy: short- and long-term observational study with functional data analysis

Andrea Corbetta, Emanuele Di Angelantonio, Andrea Ganna, Francesca Ieva



Longitudinal analysis of imprecise disease status using latent Markov models: application to Italian Thyroid Cancer Observatory data

Silvia D'Elia, Marco Alfò, Maria Francesca Marino



Long-term risk prediction from short-term data – a microsimulation approach

Moritz Pamminger, Theresa Ullmann, Moritz Madern, Daniela Dunkler, Georg Heinze



Deep learning algorithm for dynamic survival prediction with competitive risks

Tristan Margaté, Marine Zulian, Agathe Guilloux, Sandrine Katsahian



Identifying Cutoff in Predictors in Survival Analysis: An Ensemble Strategy for Flexible Knot Selection

Stefania Lando, Giulia Lorenzoni, Dario Gregori



Estimating Quality Adjusted Life Years (QALYs) from a joint modeling framework: a simulation-based study

Vincent Bonnemains, Yohann Foucher, Philippe Tessier, Etienne Dantan



An Alternative Estimand for Overall Survival in the Presence of Treatment Discontinuation: Simulation Results and Case Study

Kara-Louise Royle, David Meads, Jennifer Visser-Rogers, David A Cairns, Ian R White



Corrections of confidence interval for differences in restricted mean survival times in clinical trials with small sample sizes

Hiroya Hashimoto, Akiko Kada



Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry

Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson



Development and validation of prognostic models in phase I oncology clinical trials

Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr



Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint

Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva



Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors

Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux



Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration

Luca Genetti, Andrea Nizzardo, Marco Pergher



Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials

XINGZHI XU, SATOSHI HATTORI



Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints

Go Horiguchi, Isao Yokota, Satoshi Teramukai



Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes

Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap



Estimands in platform trials with time - treatment interactions

ZIYAN WANG, Dave Woods



A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design

Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess



Optimizing Biomarker-Based Enrichment strategies in clinical trials

Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun



Leveraging Synthetic Data for Enhanced Clinical Research Outcomes

Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska



Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL

Byoung Ha Yoon



Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM

Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk



Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models

ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI



Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand

Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian



Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol

Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme



Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards.

Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson



Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models

Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott



Automating Report Generation with Stata: A Case Study of NORUSE

Maria Elstad



Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis.

MOHAMMED ABDU MUDAWI



Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis

Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner



Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes

Mahru Ahmad, Jack Wilkinson, Andy Vail



Causal discovery for multi-cohort studies

Christine Bang, Vanessa Didelez



Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms

A F M Tahsin Shahriar, AHM Mahbub-ul Latif



Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods

Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao



Revisiting subgroup analysis: A reflection on health disparities using conditional independence

Nia Kang, Tibor Schuster



Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study

Jingya Zhao, Gareth Ambler, Baptiste Leurent



Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods.

Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden



Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome

Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz



Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis

Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka



Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative

Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier



Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol

Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango



Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates

Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume



Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial.

Robin Young, Alex McConnachie, Helen Minnis



The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation

Gregory Chen, Micahel Seo, Isaac Gravestock



Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials

Patrick Djidel, Armand Chouzy, Pierre Colin



Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance

Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock



Power calculation using the win-ratio for composite outcomes in randomized trials

David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held



Feasibility of propensity score weighted analysis in rare disease trials: a simulation study

Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini



A basket trial for rare diseases, with a crossover design for its substudies: a simulation study

Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout



Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias

Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets



Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials

Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng



Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials

Anjali Yadav

1:00pm
-
2:00pm
Lunch
Poster Exhibition: T / Tuesday posters
Location: Poster Location
 

Leveraging Wearable data for Probabilistic Imputation in Cardiovascular Risk Calculators.

Antoine Faul, Patric Wyss, Anja Mühlemann, Manuela Moraru, Danielle Bower, Petra Stute, Ben Spycher, David Ginsbourger



Stepwise Prediction of Tuberculosis Treatment Outcomes Using XGBoost and Feature-Level Analysis: A Multi-Stage Approach to Clinical Decision Support

Linfeng Wang, Jody Phelan, Taane Clark



The use of variable selection in clinical prediction modelling for binary outcomes: a systematic review

Xinrui Su, Gareth Ambler, Nathan Green, Menelaos Pavlou



Comparison of Methods for Incorporating Related Data when Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen Martin, David Jenkins



A Systematic Review of Methodological Research on Multi-State Prediction Models

Chantelle Cornett, Glen Martin, Alexander Pate, Victoria Palin



Assessing the robustness of prediction models: A case study on in-hospital mortality prediction using MIMIC-III and MIMIC-IV

Alan Balendran, Raphaël Porcher



The Influence of Variable Selection Approaches on Prediction Model Stability in Low-Dimensional Data: From Traditional Stepwise Selection to Regularisation techniques

Noraworn Jirattikanwong, Phichayut Phinyo, Pakpoom Wongyikul, Natthanaphop Isaradech, Wachiranun Sirikul, Wuttipat Kiratipaisarl



Early-detection of high-risk patient profiles admitted to hospital with respiratory infections using a multistate model

João Pedro Carmezim, Cristian Tebé, Natàlia Pallarès, Roger Paredes, Cavan Reilly



Investigating fair data acquisition for risk prediction in resource-constrained settings

Ioanna Thoma, Matthew Sperrin, Karla Diaz Ordaz, Ricardo Silva, Brieuc Lehmann



A critical benchmark of Bayesian shrinkage estimation for subgroup analysis

Sebastian Weber, Björn Bornkamp, David Ohlssen



Mathematical Modelling of Oxygenation Dynamics Using High-Resolution Perfusion Data: An Advanced Statistical Framework for Understanding Oxygen Metabolism

Mansour Taghavi Azar Sharabiani, Alireza Mahani, Richard Issitt, Yadav Srinivasan, Alex Bottle, Serban Stoica



Marginal structural Cox model with weighted cumulative exposure modelling for the estimation of counterfactual Population Attributable Fractions

Yue Zhai, Ana-Maria Vilcu, Jacques Benichou, Lucas Morin, Agnès Fournier, Anne Thiébaut, Vivian Viallon



Lost in the Forest of Forest Plots? Practical Guidelines and an All-in-One Tool for Forest Plots

Hongqiu Gu, Yong Jiang, Hao Li



Robust Outlier Detection with Skewness-Adjusted Fences: Theoretical Foundations and Applications

YUNCHAE JUNG, MINSU PARK



Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles in Linear Regression: An Application to Estimating Shelf Life

Lingjiao Wang, Yang Han, Wei Liu, Frank Bretz



One-sided simultaneous tolerance intervals based on kernel density estimates

Gian Louisse Roy



Robust large-scale multiple testing for hidden Markov random field model

Donghwan Lee, Jiyn Sun



Model informed assurance approach for 3-way PK similarity studies

Rachid El Galta, Roland Baumgartner



Korea Sequence Read Archive (KRA) - A public repository for archiving raw sequence data

JAEHO LEE



Integrative analysis of transcriptomic and epigenomic dynamics of liver organoids using single cell RNA-seq and ATAC-seq

Kwang Hoon Cho, Jong-Hwan Kim, Jimin Kim, Jahyun Yun, Dayeon Kang



Leveraging tumor imaging compositional data structure in model feature space for predicting recurrence in colorectal carcinoma

Olivia J Bobek, Nicholas Larson, Rish K Pai, Fang-Shu Ou



BayesPIM: A Bayesian Prevalence-Incidence Mixture Model for Screening Outcomes, with an Application to Colorectal Cancer

Thomas Klausch, Birgit Lissenberg-Witte, Veerle Coupé



Joint Modelling of Random Heterogeneity in Longitudinal and Multiple time-to-Events in Colon Cancer

DIVYA DENNIS, Jagathnath Krishna KM



Refining the Association between BMI, Waist Circumference, and Breast Cancer Risk in Postmenopausal Women using G-formula Method

Somin Jeon, Boyoung Park, Junghyun Yoon



Building cancer risk prediction models by synthesizing national registry and prevention trial data

Oksana Chernova, Donna Ankerst, Ruth M Pfeiffer



Modelling Individual-level Uncertainty from Missing Data in Personalised Breast Cancer Risk Prediction

Bethan L. White, Lorenzo Ficorella, Xin Yang, Douglas F. Easton, Antonis C. Antoniou



Time-varying covariates in Survival Analysis: a graphical approach to assessing the risk of cardiovascular events and aortic valve sclerosis development

Arianna Galotta, Francesco Maria Mattio, Veronika Myasoedova, Elisabetta Salvioni, Paolo Poggio, Piergiuseppe Agostoni, Alice Bonomi



Polygenic scores as tools for intervention selection in the setting of finasteride for prostate cancer prevention

Allison Meisner



Implementation of a Disease Progression Model accounting for covariates

Gabrielle Casimiro, Sofia Kaisaridi, Sophie Tezenas du Montcel



Genetics influences LDL-C response to statin therapy: short- and long-term observational study with functional data analysis

Andrea Corbetta, Emanuele Di Angelantonio, Andrea Ganna, Francesca Ieva



Longitudinal analysis of imprecise disease status using latent Markov models: application to Italian Thyroid Cancer Observatory data

Silvia D'Elia, Marco Alfò, Maria Francesca Marino



Long-term risk prediction from short-term data – a microsimulation approach

Moritz Pamminger, Theresa Ullmann, Moritz Madern, Daniela Dunkler, Georg Heinze



Deep learning algorithm for dynamic survival prediction with competitive risks

Tristan Margaté, Marine Zulian, Agathe Guilloux, Sandrine Katsahian



Identifying Cutoff in Predictors in Survival Analysis: An Ensemble Strategy for Flexible Knot Selection

Stefania Lando, Giulia Lorenzoni, Dario Gregori



Estimating Quality Adjusted Life Years (QALYs) from a joint modeling framework: a simulation-based study

Vincent Bonnemains, Yohann Foucher, Philippe Tessier, Etienne Dantan



An Alternative Estimand for Overall Survival in the Presence of Treatment Discontinuation: Simulation Results and Case Study

Kara-Louise Royle, David Meads, Jennifer Visser-Rogers, David A Cairns, Ian R White



Corrections of confidence interval for differences in restricted mean survival times in clinical trials with small sample sizes

Hiroya Hashimoto, Akiko Kada



Advantages and pitfalls of a multi-centre register collecting long-term real-world data on medical devices: Insights from a cochlear implant registry

Karin A. Koinig, Magdalena Breu, Jasmine Rinnofner, Stefano Morettini, Ilona Anderson



Development and validation of prognostic models in phase I oncology clinical trials

Maria Lee Alcober, Guillermo Villacampa, Klaus Langohr



Application of Bayesian surrogacy models to select primary endpoint in phase 2 based on relationship to a phase 3 endpoint

Alexandra Jauhiainen, Enti Spata, Patrick Darken, Carla A. Da Silva



Discontinuation and attrition rates in phase II or phase III first-line randomized clinical trials (RCTs) of solid tumors

Virginia Delucchi, Chiara Molinelli, Luca Arecco, Andrea Boutros, Davide Soldato, Matteo Lambertini, Dario Trapani, Bishal Gyawali, Gabe S Sonke, Sarah R Brown, Mattew R Sydes, Luca Boni, Saskia Litiere, Eva Blondeaux



Enhancing Dose Selection in Phase I Cancer Trials: Extending the Bayesian Logistic Regression Model with Non-DLT Adverse Events Integration

Luca Genetti, Andrea Nizzardo, Marco Pergher



Bayesian Inference of the Parametric Piecewise Accelerated Failure Time Models for Immune-oncology Clinical Trials

XINGZHI XU, SATOSHI HATTORI



Bayesian power-based sample size determination for single-arm clinical trials with time-to-event endpoints

Go Horiguchi, Isao Yokota, Satoshi Teramukai



Calibration of dose-agnostic priors for Bayesian dose-finding trial designs with multiple outcomes

Emily Alger, Shing M. Lee, Ying Kuen K. Cheung, Christina Yap



Estimands in platform trials with time - treatment interactions

ZIYAN WANG, Dave Woods



A Graphical Approach to Subpopulation Testing in Biomarker-Driven Clinical Trial Design

Boaz Natan Adler, Valeria Mazzanti, Pantelis Vlachos, Laurent Spiess



Optimizing Biomarker-Based Enrichment strategies in clinical trials

Djuly Asumpta PIERRE PAUL, Irina Irincheeva, Hong Sun



Leveraging Synthetic Data for Enhanced Clinical Research Outcomes

Szymon Musik, Agnieszka Kowalewska, Gianmarco Gallone, Jacek Zalewski, Joanna Sasin-Kurowska



Graph-Based Integration of Heterogeneous Biological Data for Precision Medicine: A Comparative Analysis of Neo4j and MySQL

Byoung Ha Yoon



Revolutionizing Clinical Data Management: A Strategic Roadmap for Integrating AI/ML into CDM

Joanna Magdalena Sasin-Kurowska, Szymon Musik, Mariusz Panczyk



Strategies to scale up model selection for analysis of proteomic datasets using multiple linear mixed-effect models

ILYA POTAPOV, MATTHEW DAVIS, ADAM BOXALL, FRANCESCO TUVERI, GEORGE WARD, SIMONE JUELIGER, HARPREET SAINI



Cost-utility analysis of sodium-glucose cotransporter-2 inhibitors on chronic kidney disease progression in diabetes patients: a real-world data in Thailand

Sukanya Siriyotha, Amarit Tansawet, Oraluck Pattanaprateep, Tanawan Kongmalai, Panu Looareesuwan, Junwei Yang, Suparee Wisawapipat Boonmanunt, Gareth J McKay, John Attia, Ammarin Thakkinstian



Comparing the Safety and Effectiveness of Covid-19 Vaccines administered in England using OpenSAFELY: A Common Analytic Protocol

Martina Pesce, Christopher Wood, Helen McDonald, Frederica Longfoot, Venexia Walker, Edward PK Parker, William J Hulme



Statistical requirements in medical diagnostic development across the UK, US, and EU markets: A review of regulation, guidelines and standards.

Timothy Hicks, Joseph Bulmer, Alison Bray, Jordan L. Oakley, Rachel L. Binks, Kile Green, Will S. Jones, James M.S. Wason, Kevin J. Wilson



Calf muscle development in NICU graduates compared with typically developing babies: an analysis of growth trajectories using linear mixed models

Alana Cavadino, Sian Williams, Malcolm Battin, Ali Mirjalili, Louise Pearce, Amy Mulqueeney, N. Susan Stott



Automating Report Generation with Stata: A Case Study of NORUSE

Maria Elstad



Maternal Mortality Rate in Sudan 2020: Causes of Death, Obstetric Characteristics and Territorial Disparity, Using Statistical Analysis.

MOHAMMED ABDU MUDAWI



Community-Based Health Screening Attendance and All-Cause Mortality in Rural South Africa: A Causal Analysis

Faith Magut, Stephen Olivier, Ariane Sessego, Lusanda Mazibuko, Jacob Busang, Dickman Gareta, Kobus Herbst, Kathy Baisely, Mark Siedner



Reducing Uncertainty in Fertility Meta-Analysis: A Multivariate Approach to Clinical Pregnancy and Live Birth Outcomes

Mahru Ahmad, Jack Wilkinson, Andy Vail



Causal discovery for multi-cohort studies

Christine Bang, Vanessa Didelez



Extension of Causal Interaction Estimation Techniques through Integration of Machine Learning Algorithms

A F M Tahsin Shahriar, AHM Mahbub-ul Latif



Embrace Variety, Find Balance: Integrating Clinical Trial and External Data Using Causal Inference Methods

Rima Izem, Yuan Tian, Robin Dunn, Weihua Cao



Revisiting subgroup analysis: A reflection on health disparities using conditional independence

Nia Kang, Tibor Schuster



Comparison of Multiple Imputation Approaches for Skewed Outcomes in Randomised Trials: a Simulation Study

Jingya Zhao, Gareth Ambler, Baptiste Leurent



Assessing the effect of drug adherence on longitudinal clinical outcomes: A comparison of Instrumental Variable and Inverse Probability Weighting methods.

Xiaoran Liang, Deniz Türkmen, Jane A H Masoli, Luke C Pilling, Jack Bowden



Compliance between different anthropometric indexes reflecting nutritional status in women with polycystic ovary syndrome

Aleksander J. Owczarek, Marta Kochanowicz, Paweł Madej, Magdalena Olszanecka-Glinianowicz



Effectiveness of different macronutrient composition diets on weight loss and blood pressure. A network meta-analysis

Katerina Nikitara, Anna-Bettina Haidich, Meropi Kontogianni, Vasiliki Bountziouka



Going from methodological research to methods guidance: the STandards for the development REseArch Methods guidance (STREAM) initiative

Malena Chiaborelli, Julian Hirt, Matthias Briel, Stefan Schandelmaier



Effectiveness of a Skill Check Sheet for Registered Dietitians: A Cluster Randomized Controlled Trial Protocol

Misa Adachi, Asuka Suzuki, Kazue Yamaoka, Mariko Watanabe, Toshiro Tango



Bootstrap-based approaches for inference on the total deviation index in agreement studies with replicates

Anna Felip-Badia, Josep L Carrasco, Sara Perez-Jaume



Baseline treatment group adjustment in the BEST study, a longitudinal randomised controlled trial.

Robin Young, Alex McConnachie, Helen Minnis



The Subtle Yet Impactful Choices in Procedure to conduct Matching-Adjusted Indirect Comparison - Insights from Simulation

Gregory Chen, Micahel Seo, Isaac Gravestock



Utility-based design: an improved approach to jointly analyze efficacy and safety in randomized comparative trials

Patrick Djidel, Armand Chouzy, Pierre Colin



Hierarchical Composite Endpoints and win ratio methods in cardiovascular trials: a systematic review and consequent guidance

Ruth Owen, John Gregson, Dylan Taylor, David Cohen, Stuart Pocock



Power calculation using the win-ratio for composite outcomes in randomized trials

David Kronthaler, Felix Beuschlein, Sven Gruber, Matthias Schwenkglenks, Ulrike Held



Feasibility of propensity score weighted analysis in rare disease trials: a simulation study

Alexander Przybylski, Francesco Ambrosetti, Lisa Hampson, Nicolas Ballarini



A basket trial for rare diseases, with a crossover design for its substudies: a simulation study

Elena G Lara, Steven Teerenstra, Kit C.B. Roes, Joanna IntHout



Comparing randomized trial designs in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias

Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats Karlsson, Andrew Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, ARCA Study group, EVIDENCE-RND Consortium, Matthis Synofzik, Emmanuelle Comets



Sequential decision making in basket trials leveraging external-trial data: with applications to rare-disease trials

Giulia Risca, Stefania Galimberti, Maria Grazia Valsecchi, Haiyan Zheng



Adaptive Designs and Bayesian Approaches: The Future of Clinical Trials

Anjali Yadav

2:00pm
-
6:00pm
Excursions

 
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