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PL7 - Wolfgang A. Wall: Unlocking vital mysteries in Respiratory Biomechanics - from bench to bedside
Time:
Wednesday, 10/Sept/2025:
4:20pm - 5:10pm
Session Chair: Daniel Hurtado Session Chair: Alessio Gizzi
Location:Auditorium CuBo
Session Abstract
The lack of information (like imaging modalities or actually any other measurement technique), that provide insights into crucial processes on the micro level of human lungs during breathing or ventilation is a huge problem in medicine. It not only hinders the development of better therapies but often even leads to scenarios where the (best intended) treatment harms (or even kills) patients, like in Ventilator Induced Lung Injury (VILI). This lack of insight and understanding can be overcome by novel and advanced physics-based computational models. Such models need to honor the complexity of the organ and include not only tissue mechanics but also flow and transport effects and need to cross scales, fields and dimensions. In this presentation I will explain essential aspects of such models including some very recent developments. It will focus on interesting and promising scientific developments but will also briefly sketch our path towards bringing such useful scientific developments to the clinics. Such approaches (of real digital twins) have a great potential and can even shift the current paradigm in health care.
