Conference Agenda
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
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Session Overview |
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PL3 - Jay Humphrey: Modeling Soft Tissue Homeostasis and Its Loss in Disease
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Mechanical homeostasis is a ubiquitous biological and physiological process whereby particular quantities are regulated to remain, within a tolerance, near preferred values called set points. Under normal conditions in adulthood, load bearing soft tissues exhibit homeostatic responses to modest perturbations in mechanical loading. By contrast, compromised or lost homeostasis is often a contributor to pathogenesis and disease progression. In this presentation, we will study mechanical homeostasis and its loss within the context of both continuum models and coupled models that integrate tissue-level biomechanics and cell signaling models. We will identify conditions that drive homeostasis and focus on inflammatory mechanisms that compromise homeostasis. Whereas the general framework will apply to most soft tissues, we will use aortic growth and remodeling as an archetype to illustrate both the methods and novel predictions. For further reading, please see [1-4]. [1]. Humphrey JD, Dufrense E, Schwartz MA (2014) Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol 15: 802-812. [2]. Humphrey JD, Schwartz MA (2021) Vascular mechanobiology: homeostasis, adaptation, and disease. Annu Rev Biomed Engr 23:1-27. [3]. Latorre M, Spronck B, Humphrey JD (2021) Complementary roles of mechanotransduction and inflammation in vascular homeostasis. Proceed R Soc A 477:20200622. [4]. Irons L, Latorre M, Humphrey JD (2021) From transcript to tissue: multiscale modeling from cell signaling to matrix remodeling. Annl Biomed Engr 49:1701-1715. |
