Konferenzprogramm

WS 2: 1

Disease Cast in Stone? Fundamental Insights into Early Origins

Markus Weckmann

Universitätsklinikum Schleswig-Holstein, Deutschland

WS 2: 2

DNAI1 mRNA in vitro treatment of DNAI1-deficient respiratory cells

Julia König¹, Kai Wohlgemuth¹, Stefanie Freischem¹, Petra Pennekamp¹, Johanna Raidt¹, Niki Tomas Loges¹, Rumpa Bhattacharjee², Mirko Hennig², Noelle Lombana², Brandon Wustman², Heymut Omran¹

¹Universitätsklinikum Münster, Klinik für Kinder- und Jugendmedizin, Deutschland; ²ReCode Therapeutics, Inc., Menlo Park, CA, USA

WS 2: 3

Protein crystals are associated with progressive pulmonary fibrosis in conditional Nedd4-2 deficient mice

Dominik Leitz^1,2,3,4, Mara Mertiny^5,6, Marie Lettau⁷, Willi Wagner^5,6,8, Maria L. Rocha⁹, Nathalie Smyczek^1,2,3, Julie C. Meyer auf der Heyde^1,2,3, Matthias Ochs⁷, Mark O. Wielpütz^5,6,8, Julia Duerr^1,2,3, Marcus A. Mall^1,2,3,4

¹Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany.; ²German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany.; ³German Center for Lung Research (DZL), associated partner site, Berlin, Germany.; ⁴Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany.; ⁵Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.; ⁶Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.; ⁷Institute of Functional Anatomy, Charité - Universitätsmedizin Berlin, Berlin, Germany.; ⁸Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.; ⁹Institute of Pathology, University Medicine Rostock, Rostock, Germany.

WS 2: 4

Neonatale Beatmungsinduzierte Lungenschädigung führt zu einer IL-6-vermittelten Entzündungsreaktion, zellulären Stressantwort und tubulären Nierenschädigung.

Celien Kuiper-Makris¹, Maria Rechmeier¹, Ivana Mizik², Christina Vohlen¹, Zülfü Cosgun¹, Sarah Stegmann³, Jan-Wilm Lackmann⁴, Eva Nüsken¹, Kai Nüsken¹, Sebastian Brähler⁴, Sandra Habbig¹, Stephan Rose-John⁵, Wolfgang Kübler⁶, Werner Seeger⁷, Jörg Dötsch¹, Miguel Alejandre Alcázar^1,7

¹Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, Uniklinik Köln, Deutschland; ²Department of Translational Pulmonology and Translational Lung Research Center Heidelberg, Uniklinik Heidelberg, Deutschland; ³Clinic for Gastroenterology and Hepatology, Uniklinik Köln, Deutschland; ⁴Cologne Excellence Cluster for Stress Responses in Ageing-associated diseases (CECAD), Universität zu Köln, Deutschland; ⁵Biochemical Institute, Universität Kiel, Deutschland; ⁶Institute of Physiology, Charité – Universitätsmedizin Berlin, Deutschland; ⁷Institute for Lung Health, Universität Gießen und Marburg Lungenzentrum (UGMLC), Mitglied des Deutschen Zentrums für Lungenforschung (DZL), Gießen, Deutschland

WS 2: 5

Investigating the role of IL6 exposure on biological aging in the context of asthma

Henriette Tugiremariya^1,2, Antonia Bohnhorst^1,2,3, Wasifa Nurieva^1,2, Markus Weckmann^1,2,3, Karosham Reddy^1,2,3

¹German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany; ²Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany; ³Division of Epigenetics of Chronic Lung Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel – Leibniz Lung Center, Borstel, Germany