Background
Artificial Intelligence (AI) is increasingly seen as a strategic driver of innovation in healthcare systems, offering the potential to improve clinical effectiveness, optimize resource use, and support decision-making. One promising application is the use of AI-powered Clinical Decision Support Systems (CDSS), particularly in primary care, where general practitioners (GPs) often face high workloads, limited time, and incomplete information (Rajkomar et al.). In Italy, the NHS shows notable regional differences in prescription habits and healthcare consumption that are linked to local clinical cultures and practices. These disparities result in inefficiencies, inequalities, and reduced effectiveness in public healthcare spending.
To address these issues, the Italian Ministry of Health, through its technical agency Agenas, has launched a nationwide initiative to provide GPs with a CDSS powered by AI. This tool aims to improve diagnostic accuracy, support personalized care plans, strengthen chronic disease management, and enhance preventive services. While this initiative aligns with broader goals of digitalizing territorial healthcare, the presence of technology alone does not ensure successful adoption (Roppelt et al.).
Objectives and Research Questions
This study explores the multi-level challenges and opportunities associated with the adoption of AI-driven CDSS in primary care. The research focuses on two key levels:
• Professional level: It is crucial to explore how GPs perceive AI prior to implementation. Clinicians’ interpretations of new technologies play a fundamental role in their development, deployment, and appropriation (Leonardi & Barley, 2010). AI might be seen as a support tool that enhances decision-making, or as a threat to autonomy and the doctor-patient relationship.
• Organizational level: Healthcare organizations must adapt service models to integrate CDSS into existing clinical workflows without disrupting care continuity. This involves prioritizing patient needs, ensuring coordination among providers, and aligning the CDSS with operational strategies.
Based on this twofold focus, the study will answer the following research questions:
1. How do General Practitioners perceive AI prior to its adoption—as a technological tool and in terms of its impact on the patient relationship, professional autonomy, and identity? Which conditions do they consider necessary for its successful adoption?
2. What are the expected benefits of the AI-CDSS for healthcare managers, what change management strategies do they propose, and what role do they attribute to Local Health Authorities in facilitating its adoption in primary care?
Methodology
A qualitative, multi-level research design will be used, including:
(i) semi-structured interviews with key GP opinion leaders across Italy to explore expectations, barriers, and enablers of CDSS adoption;
(ii) survey to managers of Local Health Authorities to examine organizational strategies, change management, and training needs.
Expected Results
The study will generate practical insights for promoting CDSS adoption at both professional and organizational levels. It will identify drivers of AI acceptance, suggest engagement strategies for GPs, and offer recommendations on care model redesign, training, and incentives. Ultimately, it aims to contribute to a more effective, sustainable, and equitable healthcare system enhanced by AI.