Conference Agenda
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SS8: Oxidative potential of aerosol particles and health risks (II)
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12:45pm - 1:00pm
FR2-3: 1 KM-SUB-OP: A kinetic model of aerosol oxidative potential 1Department of Multiphase Chemistry, Max Planck Institute for Chemistry, Mainz, 55128, Germany; 2MRC Centre for Environment and Health, Imperial College London, 86 Wood Lane, London W12 0BZ, UK; 3School of Geography Earth and Environmental Science, University of Birmingham, Birmingham B15 2TT, UK; 4Institut National de L'Environnement Industriel et des Risques (INERIS), Verneuil en Halatte, France; 5INRS, 1 rue du Morvan CS 60027, 54519, Vandoeuvre-lès-Nancy, France; 6Laboratoire des Sciences du Climat et de l'Environnement, CNRS-CEA-UVSQ, Gif-sur-Yvette, 91191, France; 7University of Florence, Dipartimento di Fisica Astronomia, 50019 Sesto Fiorentino, Italy; 8IMT Nord Europe, Université de Lille, Centre for Energy and Environnement, 59000 Lille, France; 9Institut des Géosciences de l'Environnement, IGE, UMR 5001, F-38000 Grenoble, France; 10Department of Environmental Sciences, University of Basel, 4056 Basel, Switzerland; 11Environmental and Life Sciences, Trent University, Peterborough, Canada Measuring the oxidative potential (OP) of atmospheric particles is used to assess their toxicity. We present a chemical kinetics model of aerosol oxidative potential to quantify the effects of particles on the production of reactive oxygen species and the depletion of ascorbic acid and dithiothreitol. An inverse modelling framework was applied to laboratory OP data. We extrapolate the findings from the laboratory experiments to field data, and find good agreement between the model and data across three sites. We further extend the to a multiphase kinetic model of the respiratory tract to translate assay-based OP into biomarkers of oxidative stress.
1:00pm - 1:15pm
FR2-3: 2 Exploring the human health effects of indoor air pollutants using cellular and acellular approaches 1The University of Manchester, United Kingdom; 2Helmholtz Zentrum München, Germany; 3Imperial College London, United Kingdom; 4Division of Cardiovascular Sciences, University of Manchester, United Kingdom; 5Division of Immunology, Immunity to Infection and Respiratory Medicine, University of Manchester, United Kingdom; 6University of Basel, Switzerland Poor indoor air quality can have a significant impact on occupants’ health and well-being. Despite this evidence, there are still major gaps in our understanding of the most important harmful pollutant components and their mechanisms of toxicity. This project aimed to investigate the mechanisms by which two dominant indoor air pollution sources (cooking and cleaning activities) can cause pulmonary adverse effects. A combination online of air-liquid interface lung epithelial cell exposure and accellular oxidative potential were used to link the chemical composition of the aerosol with adverse acellular and cellular toxicity measurements.
1:15pm - 1:30pm
FR2-3: 3 An Integrated Multiple Approach to Investigate the Complexity of OP Source Apportionment 1Department of Environmental Biology, Sapienza University of Rome; 2C.N.R. Institute of Atmospheric Pollution Research; 3ARPA Lazio, Regional Environmental Protection Agency; 4Department of Public Health and Infectious Diseases, Sapienza University of Rome; 5Department of Chemistry, Sapienza University of Rome; 6ARPA Umbria, Regional Environmental Protection Agency; 7Italian Ministry of Health This study tackles key challenges in using oxidative potential (OP) to estimate health effects induced by various particulate matter (PM) sources. We employed OPDTT, OPAA, and OPDCFH on more than one thousand fully chemically characterized PM samples collected in three urban/industrial areas of Italy. Samples were collected in each area using multi-stage impactors, conventional one-site daily samplings, and innovative spatially-resolved, long-term samplings. Source apportionment of PM10 and its OP was performed using PMF, principal component analysis (PCA), and focused PCA. Size distribution analyses and spatially-resolved data significantly enhanced OP source apportionment, allowing for a more thorough investigation of its complexity.
1:30pm - 1:45pm
FR2-3: 4 Role of chemical compositions in oxidative potential of airborne dust in INQUIRE homes from the UK, Slovenia and Sweden 1University of Cambridge, United Kingdom; 2Bradford Institute for Health Research, United Kingdom; 3Jožef Stefan Institute, Slovenia; 4Karlstad University, Sweden This study examines the oxidative potential (OP) of airborne particulate matter (PM) and settled dust from homes in Slovenia, Sweden, and the UK, as part of the INQUIRE project. Using simulated lung fluid and LC-MS, antioxidant depletion rates (ascorbic acid, glutathione, cysteine) and glutathione disulfide accumulation were measured. Preliminary results show a strong correlation between PM mass and the initial depletion rate of ascorbic acid, and the later depletion phase of glutathione. These patterns suggest distinct oxidative mechanisms involving organics and soluble metals. These findings emphasize the potential health risks of indoor PM, particularly through oxidative stress in respiratory pathways.
1:45pm - 2:00pm
FR2-3: 5 Development of a Portable Electrochemical Sensor for Real-Time Monitoring of Atmospheric Aerosol Oxidative Activity 1Department of Physical Chemistry, School of Industrial and Aerospace Engineering, Institute of Nanoscience, Nanotechnology and Molecular Materials (Inamol), Universidad de Castilla-La Mancha (UCLM); 2Department of Inorganic, Organic and Biochemical Chemistry, Faculty of Environmental Sciences and Biochemistry, Inamol, UCLM; 3Department of Physical Chemistry, Higher Technical School of Industrial Engineering, UCLM In the present work, for first time an electrochemical sensor was developed for monitoring oxidative potential with high sensitivity and easy operation using portable devices. The proposed approach is based on ascorbic acid assay where, after being oxidized by particulate matter, the remaining ascorbic acid is analyzed directly by flow injection analysis with chronoamperometric detection using a screen-printed carbon electrode modified with azure-A polymer and platinum nanoparticles.
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